International journal of thyroidology

Korean Thyroid Association (대한갑상선학회)
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Methimazole-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in the Peripheral Nerves

  • Kang, Mi Il (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Kim, Dohee (Department of Internal Medicine, Dankook University College of Medicine)
  • Received : 2018.03.17
  • Accepted : 2018.05.24
  • Published : 2018.11.30
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Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis has been reported in Graves' disease patients treated with antithyroid drugs (ATDs), especially propylthiouracil. ATD-induced ANCA-associated vasculitis usually involved the kidneys followed by the respiratory organs and skin. The treatment of ANCA-associated vasculitis induced by ATDs is to stop ATD therapy immediately, which often leads to an overall good prognosis. We report a case of ANCA-associated vasculitis in the peripheral nerves of the lower extremities in a 66-year-old woman who was treated with methimazole (MMI) for Graves' disease. To our knowledge, this is the third case of peripheral nervous system (PNS) involvement of ATD-induced vasculitis and the first case of PNS vasculitis associated with MMI.

Keywords

References

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