Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Study of Lipid Coated Polymeric Nanoparticles for Lung Metastasis

폐 전이 암에 대한 Lipid Coated Polymeric Nanoparticles에 관한 연구

  • Park, Junyoung (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine) ;
  • Park, Sanghyo (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Jo, Yerim (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine) ;
  • Jeong, Minji (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Kim, Inwoo (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Kang, Wonjun (Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine) ;
  • Key, Jaehong (Department of Biomedical Engineering, College of Health Sciences, Yonsei University)
  • 박준영 (연세대학교 의과대학 신촌세브란스병원 핵의학과) ;
  • 박상효 (연세대학교 보건과학대학 의공학부) ;
  • 조예림 (연세대학교 의과대학 신촌세브란스병원 핵의학과) ;
  • 정민지 (연세대학교 보건과학대학 의공학부) ;
  • 김인우 (연세대학교 보건과학대학 의공학부) ;
  • 강원준 (연세대학교 의과대학 신촌세브란스병원 핵의학과) ;
  • 기재홍 (연세대학교 보건과학대학 의공학부)
  • Received : 2018.03.29
  • Accepted : 2018.06.26
  • Published : 2018.08.31
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Abstract

Lung cancer and pulmonary metastasis are the leading cause of cancer mortality worldwide. Survival for patients with lung metastases is about 5%. Nanoparticles have been developed for the imaging and treatment of various cancers, including pulmonary malignancies. In this work, we report lipid coated polymeric nanoparticles (LPNs) with an average diameter of 154 nm. In vivo performance of LPNs was characterized using optical imaging system. We expect this nanoparticle can be used for finding lung cancer or lung metastasis. Eventually loading therapeutic drug with the nanoparticle will be utilized for cancer diagnosis and effective therapy at the same time.

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References

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