Journal of the Korean Society of Visualization (한국가시화정보학회지)

The Korean Society of Visualization (한국가시화정보학회)
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Evaluation of the Biomechanical Characteristics of Ischemic Mitral Regurgitation: Effects of Asymmetric Papillary Muscle Displacement and Annular Dilation

허혈성 승모판막 폐쇄부전의 생체역학적 특성 분석: 비대칭적 유두근 변위와 판륜 확장의 영향

  • Hong, Woojae (Department of Biomechatronic Engineering, Sungkyunkwan University) ;
  • Kim, Hyunggun (Department of Biomechatronic Engineering, Sungkyunkwan University)
  • Received : 2018.08.06
  • Accepted : 2018.08.20
  • Published : 2018.08.31
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Abstract

Ischemic mitral regurgitation (IMR) is the primary mitral valve (MV) pathology in the aftermath of myocardial infarction as a consequence of regional left ventricular (LV) remodeling. We investigated the effect of asymmetric papillary muscle (PM) displacement and annular dilation on IMR development. Virtual MV modeling was performed to create a normal human MV. Asymmetric PM displacement, asymmetric annular dilation, and the combination of these two pathologic characteristics were modeled. Dynamic finite element evaluation of MV function was performed across the complete cardiac cycle for the normal and three different IMR MV models. While the normal MV demonstrated complete leaflet coaptation, each pathologic MV model clearly revealed deteriorated leaflet coaptation and abnormal stress distributions. The pathologic MV model having both asymmetric PM displacement and annular dilation showed the worst leaflet malcoaptation. Simulation-based biomechanical evaluation of post-ischemic LV remodeling provides an excellent tool to better understand the pathophysiologic mechanism of IMR development.

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References

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