References
- Wendel AA, Purushotham A, Liu LF, Belury MA. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. Journal of lipid research. 2008;49(1):98-106. https://doi.org/10.1194/jlr.M700195-JLR200
- Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature reviews Immunology. 2006;6(10):772-783. https://doi.org/10.1038/nri1937
- James PT, Leach R, Kalamara E, Shayeghi M. The worldwide obesity epidemic. Obesity research. 2001;9 Suppl 4:228S-233S. https://doi.org/10.1038/oby.2001.123
- Zimmet P. The burden of type 2 diabetes: are we doing enough? Diabetes & metabolism. 2003;29(4 Pt 2):6S9-18. https://doi.org/10.1016/S1262-3636(03)72783-9
- Kunitomi M, Wada J, Takahashi K, Tsuchiyama Y, Mimura Y, Hida K, Miyatake N, Fujii M, Kira S, Shikata K, Maknio H. Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2002;26(3):361-369. https://doi.org/10.1038/sj.ijo.0801899
- Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, Shikata K, Hourai S, Futami J, Watanabe E, Matsuki Y, Hiramatsu R, Akagi S, Makino H, Kanwar YS. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(30):10610-10615. https://doi.org/10.1073/pnas.0504703102
- Lebovitz HE. Insulin resistance: definition and consequences. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2001;109 Suppl 2:S135-148. https://doi.org/10.1055/s-2001-18576
- Goldstein BJ. Insulin resistance as the core defect in type 2 diabetes mellitus. The American journal of cardiology. 2002;90(5A):3G-10G.
- Angulo P. Nonalcoholic fatty liver disease. The New England journal of medicine. 2002;346(16):1221-1231. https://doi.org/10.1056/NEJMra011775
- Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocrine reviews. 2005;26(3):439-451. https://doi.org/10.1210/er.2005-0005
- Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes: scientific review. Jama. 2002;287(3):360-372. https://doi.org/10.1001/jama.287.3.360
- Kang SJ, Lee JE, Lee EK, Jung DH, Song CH, Park SJ, Choi SH, Han CH, Ku SK, Lee YJ. Fermentation with Aquilariae Lignum enhances the anti-diabetic activity of green tea in type II diabetic db/db mouse. Nutrients. 2014;6(9):3536-3571. https://doi.org/10.3390/nu6093536
- Jung YM, Lee SH, Lee DS, You MJ, Chung IK, Cheon WH, Kwon YS, Lee YJ, Ku SK. Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutrition research (New York, NY). 2011;31(5):387-396. https://doi.org/10.1016/j.nutres.2011.04.005
- Kim CM, Yi SJ, Cho IJ, Ku SK. Red-koji fermented red ginseng ameliorates high fat diet-induced metabolic disorders in mice. Nutrients. 2013;5(11):4316-4332. https://doi.org/10.3390/nu5114316
- Choi JS, Kim JW, Park JB, Pyo SE, Hong YK, Ku SK, Kim MR. Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes. International journal of molecular medicine. 2017;39(6):1437-1451. https://doi.org/10.3892/ijmm.2017.2967
- Chen H, Qu Z, Fu L, Dong P, Zhang X. Physicochemical properties and antioxidant capacity of 3 polysaccharides from green tea, oolong tea, and black tea. Journal of food science. 2009;74(6):C469-474. https://doi.org/10.1111/j.1750-3841.2009.01231.x
- Hays NP, Galassetti PR, Coker RH. Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventions. Pharmacology & therapeutics. 2008;118(2):181-191. https://doi.org/10.1016/j.pharmthera.2008.02.003
- Elkahoui S, Bartley GE, Yokoyama WH, Friedman M. Dietary Supplementation of Potato Peel Powders Prepared from Conventional and Organic Russet and Non-organic Gold and Red Potatoes Reduces Weight Gain in Mice on a High-Fat Diet. Journal of agricultural and food chemistry. 2018;66(24):6064-6072. https://doi.org/10.1021/acs.jafc.8b01987
- Ju R, Zheng S, Luo H, Wang C, Duan L, Sheng Y, Zhao C, Xu W, Huang K. Purple Sweet Potato Attenuate Weight Gain in High Fat Diet Induced Obese Mice. Journal of food science. 2017;82(3):787-793. https://doi.org/10.1111/1750-3841.13617
- Kim MH, Park SC, Kim JY, Lee SY, Lim HT, Cheong H, Hahm KS, Park Y. Purification and characterization of a heat-stable serine protease inhibitor from the tubers of new potato variety "Golden Valley". Biochemical and biophysical research communications. 2006;346(3):681-686. https://doi.org/10.1016/j.bbrc.2006.05.186
- Komarnytsky S, Cook A, Raskin I. Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism. International journal of obesity (2005). 2011;35(2):236-243. https://doi.org/10.1038/ijo.2010.192
- Ku SK, Sung SH, Choung JJ, Choi JS, Shin YK, Kim JW. Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice. Experimental and therapeutic medicine. 2016;12(1):354-364. https://doi.org/10.3892/etm.2016.3256
- Lee DG, Park SI, Kang SJ, Kim JW, Lee EK, Song CH, Han CH, Lee YJ, Ku SK. In vitro antioxidant and anti-adipogenic effects of slendesta, standard potato extracts containing 5% protease inhibitor II. African Journal of Traditional, Complementary and Alternative Medicines. 2016;13(2):164-175. https://doi.org/10.4314/ajtcam.v13i2.20
- Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology. 2004;145(7):3258-3264. https://doi.org/10.1210/en.2004-0219
- Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nature medicine. 2000;6(9):998-1003. https://doi.org/10.1038/79697
- Kurundkar SB, Sachan N, Kodam KM, Kulkarni VM, Bodhankar SL, Ghole VS. Effect of a novel biphenyl compound, VMNS2e on ob/ob mice. European journal of pharmacology. 2011;650(1):472-478. https://doi.org/10.1016/j.ejphar.2010.09.067
- Plummer MR, Hasty AH. Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice. The Journal of nutritional biochemistry. 2008;19(10):664-673. https://doi.org/10.1016/j.jnutbio.2007.08.009
- Margalit M, Shalev Z, Pappo O, Sklair-Levy M, Alper R, Gomori M, Engelhardt D, Rabbani E, Ilan Y. Glucocerebroside ameliorates the metabolic syndrome in OB/OB mice. The Journal of pharmacology and experimental therapeutics. 2006;319(1):105-110. https://doi.org/10.1124/jpet.106.104950
- Sone H, Suzuki H, Takahashi A, Yamada N. Disease model: hyperinsulinemia and insulin resistance. Part A-targeted disruption of insulin signaling or glucose transport. Trends in molecular medicine. 2001;7(7):320-322. https://doi.org/10.1016/S1471-4914(01)02041-X
- Park SH, Ko SK, Chung SH. Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. Journal of ethnopharmacology. 2005;102(3):326-335. https://doi.org/10.1016/j.jep.2005.06.041
- Ma A, Wang J, Yang L, An Y, Zhu H. AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE-/- mice. Journal of lipid research. 2017;58(8):1536-1547. https://doi.org/10.1194/jlr.M073270
- Korea Food and Drug Administration. Testing Guidelines for Safety Evaluation of Drugs. In: Korea Food and Drug Administration, editor. 2015.
- Lee JE, Kang SJ, Choi SH, Song CH, Lee YJ, Ku SK. Fermentation of Green Tea with 2% Aquilariae lignum Increases the Anti-Diabetic Activity of Green Tea Aqueous Extracts in the High Fat-Fed Mouse. Nutrients. 2015;7(11):9046-9078. https://doi.org/10.3390/nu7115447
- Chung SI, Rico CW, Kang MY. Comparative study on the hypoglycemic and antioxidative effects of fermented paste (doenjang) prepared from soybean and brown rice mixed with rice bran or red ginseng marc in mice fed with high fat diet. Nutrients. 2014;6(10):4610-4624. https://doi.org/10.3390/nu6104610
- Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. The Journal of biological chemistry. 1957;226(1):497-509.
- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. The Journal of biological chemistry. 1951;193(1):265-275.
- Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clinical chemistry. 1988;34(3):497-500.
- Hulcher FH, Oleson WH. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. Journal of lipid research. 1973;14(6):625-631.
- Davidson AL, Arion WJ. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Archives of biochemistry and biophysics. 1987;253(1):156-167. https://doi.org/10.1016/0003-9861(87)90648-5
- Alegre M, Ciudad CJ, Fillat C, Guinovart JJ. Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Analytical biochemistry. 1988;173(1):185-189. https://doi.org/10.1016/0003-2697(88)90176-5
- Bentle LA, Lardy HA. Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase. The Journal of biological chemistry. 1976;251(10):2916-2921.
- Sung YY, Kim DS, Kim SH, Kim HK. Anti-obesity activity, acute toxicity, and chemical constituents of aqueous and ethanol Viola mandshurica extracts. BMC complementary and alternative medicine. 2017;17(1):297. https://doi.org/10.1186/s12906-017-1810-4
- Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nature protocols. 2008;3(6):1101-1108. https://doi.org/10.1038/nprot.2008.73
- Kawakami S, Han KH, Nakamura Y, Shimada K, Kitano T, Aritsuka T, Nagura T, Ohba K, Nakamura K, Fukushima M. Effects of dietary supplementation with betaine on a nonalcoholic steatohepatitis (NASH) mouse model. Journal of nutritional science and vitaminology. 2012;58(5):371-375. https://doi.org/10.3177/jnsv.58.371
- Fujita H, Fujishima H, Koshimura J, Hosoba M, Yoshioka N, Shimotomai T, Morii T, Narita T, Kakei M, Ito S. Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice. Endocrine journal. 2005;52(4):427-433. https://doi.org/10.1507/endocrj.52.427
- Mitchell M, Armstrong DT, Robker RL, Norman RJ. Adipokines: implications for female fertility and obesity. Reproduction (Cambridge, England). 2005;130(5):583-597. https://doi.org/10.1530/rep.1.00521
- Wilson JS, Korsten MA, Leo MA, Lieber CS. Combined effects of protein deficiency and chronic ethanol consumption on rat pancreas. Digestive diseases and sciences. 1988;33(10):1250-1259. https://doi.org/10.1007/BF01536675
- Gartner LP, Hiatt JL. Color Textbook of Histology. 3rd ed. Philadelphia: Saunders; 2007.
- Snedeker SM, Hay AG. Do interactions between gut ecology and environmental chemicals contribute to obesity and diabetes? Environmental health perspectives. 2012;120(3):332-339. https://doi.org/10.1289/ehp.1104204
- Larsen ML, Horder M, Mogensen EF. Effect of long-term monitoring of glycosylated hemoglobin levels in insulin-dependent diabetes mellitus. The New England journal of medicine. 1990;323(15):1021-1025. https://doi.org/10.1056/NEJM199010113231503
- Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T. Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. The Journal of clinical investigation. 2007;117(1):246-257. https://doi.org/10.1172/JCI17645
- Noriega-Lopez L, Tovar AR, Gonzalez-Granillo M, Hernandez-Pando R, Escalante B, Santillan-Doherty P, Torres N. Pancreatic insulin secretion in rats fed a soy protein high fat diet depends on the interaction between the amino acid pattern and isoflavones. The Journal of biological chemistry. 2007;282(28):20657-20666. https://doi.org/10.1074/jbc.M701045200
- Neves RH, Alencar AC, Aguila MB, Mandarim-de-Lacerda CA, Machado-Silva JR, Gomes DC. Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet. Memorias do Instituto Oswaldo Cruz. 2006;101 Suppl 1:253-260. https://doi.org/10.1590/S0074-02762006000900039
- Quine SD, Raghu PS. Effects of (-)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart. Pharmacological reports : PR. 2005;57(5):610-615.
- Sodikoff C. Laboratory Profiles of Small Animal Diseases: A Guide to Laboratory Diagnosis. 2nd ed. St. Louise: Mosby; 1995.
- Garg MC, Singh KP, Bansal DD. Effect of vitamin C supplementation on oxidative stress in experimental diabetes. Indian journal of experimental biology. 1997;35(3):264-266.
- Ceriello A, Quatraro A, Giugliano D. New insights on non-enzymatic glycosylation may lead to therapeutic approaches for the prevention of diabetic complications. Diabetic medicine : a journal of the British Diabetic Association. 1992;9(3):297-299. https://doi.org/10.1111/j.1464-5491.1992.tb01783.x
- Maiese K. New Insights for Oxidative Stress and Diabetes Mellitus. Oxidative medicine and cellular longevity. 2015;2015:875961.
- Akbel E, Arslan-Acaroz D, Demirel HH, Kucukkurt I, Ince S. The subchronic exposure to malathion, an organophosphate pesticide, causes lipid peroxidation, oxidative stress, and tissue damage in rats: the protective role of resveratrol. Toxicology research. 2018;7(3):503-512. https://doi.org/10.1039/C8TX00030A
- Jung UJ, Park YB, Kim SR, Choi MS. Supplementation of persimmon leaf ameliorates hyperglycemia, dyslipidemia and hepatic fat accumulation in type 2 diabetic mice. PloS one. 2012;7(11):e49030. https://doi.org/10.1371/journal.pone.0049030
- Wu D, Wen W, Qi CL, Zhao RX, Lu JH, Zhong CY, Chen YY. Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012;19(8-9):712-718. https://doi.org/10.1016/j.phymed.2012.03.003
- Wu D, Zheng N, Qi K, Cheng H, Sun Z, Gao B, Zhang Y, Pang W, Huangfu C, Ji S, Xue M, Ji A, Li Y. Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential. Medical gas research. 2015;5(1):1. https://doi.org/10.1186/s13618-014-0022-y
- Coope GJ, Atkinson AM, Allott C, McKerrecher D, Johnstone C, Pike KG, Holme PC, Vertigan H, Gill D, Coghlan MP, Leighton B. Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. British journal of pharmacology. 2006;149(3):328-335. https://doi.org/10.1038/sj.bjp.0706848
- van Schaftingen E, Gerin I. The glucose-6-phosphatase system. The Biochemical journal. 2002;362(Pt 3):513-532. https://doi.org/10.1042/bj3620513
- Lin CH, Kuo YH, Shih CC. Effects of Bofu-Tsusho-San on diabetes and hyperlipidemia associated with AMP-activated protein kinase and glucose transporter 4 in high-fat-fed mice. International journal of molecular sciences. 2014;15(11):20022-20044. https://doi.org/10.3390/ijms151120022
- Dulloo AG, Seydoux J, Jacquet J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiology & behavior. 2004;83(4):587-602. https://doi.org/10.1016/j.physbeh.2004.07.028
- Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes. 2003;52(6):1355-1363. https://doi.org/10.2337/diabetes.52.6.1355