Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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Regulation of lubricin for functional cartilage tissue regeneration: a review

  • Lee, Yunsup (School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University) ;
  • Choi, Jaehoon (School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University) ;
  • Hwang, Nathaniel S. (School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University)
  • Received : 2017.11.26
  • Accepted : 2018.03.05
  • Published : 2018.06.01
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Abstract

Background: Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and multifaceted matter is a major concern in the field of cartilage tissue engineering. Main body: Although a noticeable progress has been made toward cartilage tissue regeneration through numerous approaches such as autologous chondrocyte implantation, osteochondral grafts, and microfracture technique, the functionality of engineered cartilage is a challenge for complete reconstruction of cartilage. Thus, delicate modulation of lubricin along with cell/scaffold application will expand the research on cartilage tissue engineering. Conclusion: In this review, we will discuss the empirical analysis of lubricin from fundamental interpretation to the practical design of gene expression regulation.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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