Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Impact of positive/close margins in oropharyngeal cancer according to the HPV status

HPV 관련성에 따른 구인두암에서의 positive/close 절제연의 의미

  • Jung, Yuh-Seog (Dept. of Otorhinolaryngology, Center for Thyroid Cancer, Dept. of Immunotherapeutics, National Cancer Center)
  • 정유석 (국립암센터 갑상선암센터, 면역치료연구과, 국제암대학원대학교)
  • Received : 2018.11.11
  • Accepted : 2018.11.12
  • Published : 2018.11.30
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Abstract

With the emerging knowledge about tumor biology specific for human papillomavirus (HPV)-related head and neck cancers, the classical understanding about the curative surgery in head and neck cancers are starting to progress, customized for their HPV-associations and ultimately specific for tumor biologic characteristics. The common rule for surgery should reflect the biologic characteristics of target tumors, but still, multi-institutional large-scale data could be scarce, due to the subjective feature of surgical treatment itself. However, the impact of HPV for margin determination is now being questioned by multiple groups, and typical example is European Cooperative Oncology Group (ECOG)-3311 study. Here, we review the impact of viral association for surgical decision and its biological background and implications.

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References

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