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Multiscale Clustering and Profile Visualization of Malocclusion in Korean Orthodontic Patients : Cluster Analysis of Malocclusion

  • Jeong, Seo-Rin (Department of Orthodontics, School of Dentistry, Chosun University) ;
  • Kim, Sehyun (Natural Science Research Institute, Korea Advanced Institute of Science and Technology) ;
  • Kim, Soo Yong (Department of Physics, Korea Advanced Institute of Science and Technology) ;
  • Lim, Sung-Hoon (Department of Orthodontics, School of Dentistry, Chosun University)
  • 투고 : 2018.05.01
  • 심사 : 2018.05.28
  • 발행 : 2018.06.30

초록

Understanding the classification of malocclusion is a crucial issue in Orthodontics. It can also help us to diagnose, treat, and understand malocclusion to establish a standard for definite class of patients. Principal component analysis (PCA) and k-means algorithms have been emerging as data analytic methods for cephalometric measurements, due to their intuitive concepts and application potentials. This study analyzed the macro- and meso-scale classification structure and feature basis vectors of 1020 (415 male, 605 female; mean age, 25 years) orthodontic patients using statistical preprocessing, PCA, random matrix theory (RMT) and k-means algorithms. RMT results show that 7 principal components (PCs) are significant standard in the extraction of features. Using k-means algorithms, 3 and 6 clusters were identified and the axes of PC1~3 were determined to be significant for patient classification. Macro-scale classification denotes skeletal Class I, II, III and PC1 means anteroposterior discrepancy of the maxilla and mandible and mandibular position. PC2 and PC3 means vertical pattern and maxillary position respectively; they played significant roles in the meso-scale classification. In conclusion, the typical patient profile (TPP) of each class showed that the data-based classification corresponds with the clinical classification of orthodontic patients. This data-based study can provide insight into the development of new diagnostic classifications.

키워드

참고문헌

  1. Proffit WR FH, Sarver DM. Contemporary orthodontics. 5th ed. St Louis: Mosby; 2013.
  2. Angle EH. Classification of malocclusion. Dental Cosmos. 1899;41:248-264,350-357.
  3. Wiwie C, Baumbach J, Rottger R. Comparing the performance of biomedical clustering methods. Nat Methods. 2015;12(11):1033-1038. doi: 10.1038/nmeth.3583.
  4. Wirapati P, Sotiriou C, Kunkel S, Farmer P, Pradervand S, Haibe-Kains B, Desmedt C, Ignatiadis M, Sengstag T, Schutz F, Goldstein DR, Piccart M, Delorenzi M. Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res. 2008;10(4):R65. doi:10.1186/bcr2124.
  5. Wittkop T, Emig D, Truss A, Albrecht M, Bocker S, Baumbach J. Comprehensive cluster analysis with Transitivity Clustering. Nat Protoc. 2011;6:285-295. doi: 10.1038/nprot.2010.197.
  6. Rottger R, Kalaghatgi P, Sun P, Soares Sde C, Azevedo V, Wittkop T, Baumbach J. Density parameter estimation for finding clusters of homologous proteins-tracing actinobacterial pathogenicity lifestyles. Bioinformatics. 2013;29(2):215-222. doi: 10.1093/bioinformatics/bts653.
  7. Choi EK, Lee JH, Baek SH, Kim SJ. Gene expression profile altered by orthodontic tooth movement during healing of surgical alveolar defect. Am J Orthod Dentofacial Orthop. 2017;151(6):1107-15. doi: 10.1016/j.ajodo.2016.10.039.
  8. Bui C, King T, Proffit W, Frazier-Bowers S. Phenotypic characterization of Class III patients. Angle Orthod. 2006;76:564-569. doi: 10.1043/0003-3219(2006)076[0564:PCOCIP]2.0.CO;2.
  9. Hirschfeld WJ, Moyers RE, Enlow DH. A method of deriving subgroups of a population: A study of craniofacial taxonomy. Am J Phys Anthropol. 1973;39:279-290. doi: 10.1002/ajpa.1330390219.
  10. Hong SX, Yi CK. A classification and characterization of skeletal class III malocclusion on etio-pathogenic basis. Int J Oral Maxillofac Surg. 2001;30:264-271. https://doi.org/10.1054/ijom.2001.0088
  11. Hwang HS, Youn IS, Lee KH, Lim HJ. Classification of facial asymmetry by cluster analysis. Am J Orthod Dentofacial Orthop. 2007;132:279.e271-276. doi: 10.1016/j.ajodo.2007.01.017.
  12. Kim J-Y, Lee S-J, Kim T-W, Nahm D-S, Chang Y-I. Classification of the skeletal variation in normal occlusion. Angle Orthod. 2005;75:311-319. doi: 10.1043/0003-3219(2005)75[311:COTSVI]2.0.CO;2.
  13. Li C, Cai Y, Chen S, Chen F. Classification and characterization of class III malocclusion in Chinese individuals. Head Face Med. 2016;12:31. doi: 10.1186/s13005-016-0127-8.
  14. Moreno Uribe LM, Howe SC, Kummet C, Vela KC, Dawson DV, Southard TE. Phenotypic diversity in white adults with moderate to severe Class II malocclusion. Am J Orthod Dentofacial Orthop. 2014;145:305-316. doi: 10.1016/j.ajodo.2013.11.013.
  15. Moreno Uribe LM, Vela KC, Kummet C, Dawson DV, Southard TE. Phenotypic diversity in white adults with moderate to severe Class III malocclusion. Am J Orthod Dentofacial Orthop. 2013;144:32-42. doi: 10.1016/j.ajodo.2013.02.019.
  16. Ahn KS, Baik HS, Kim KH, Kim BI, Lee KJ. Subclassification of Skeletal Class II Malocclusion of Korean Adults Using Cluster Analysis. Korean J Cleft Lip and Palate. 2011;14:1-18.
  17. Park IC, Bowman D, Klapper L. A cephalometric study of Korean adults. Am J Orthod Dentofacial Orthop. 1989;96:54-59. https://doi.org/10.1016/0889-5406(89)90229-1
  18. The faculty of department of orthodontics. Textbook of Orthodontics. 3rd ed. Seoul, Korea: Jisung, Daehannarae publishing, 2014.
  19. Roweis ST, Saul LK. Nonlinear Dimensionality Reduction by Locally Linear Embedding. Science 2000;290:2323-2326. doi: 10.1126/science.290.5500.2323.
  20. Gopikrishnan P, Rosenow B, Plerou V, Stanley HE. Quantifying and interpreting collective behavior in financial markets. Phys Rev E Stat Nonlin Soft Matter Phys. 2001;64:035106. doi: 10.1103/PhysRevE.64.035106.
  21. Laloux L, Cizeau P, Bouchaud J-P, Potters M. Noise Dressing of Financial Correlation Matrices. Phys Rev Lett. 1999;83:1467-1470. doi: 10.1103/PhysRevLett.83.1467.
  22. Jain AK. Data clustering: 50 years beyond K-means. Pattern Recognit Lett. 2010;31:651-666. doi: 10.1016/j.patrec.2009.09.011.
  23. Lloyd S. Least squares quantization in PCM. IEEE Trans Inf Theory. 1982;28:129-137. doi: 10.1109/TIT.1982.1056489.
  24. Tibshirani R, Walther G, Hastie T. Estimating the number of clusters in a data set via the gap statistic. J R Stat Soc Series B Stat Methodol. 2001;63:411-423. doi: 10.1111/1467-9868.00293.