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Neurolymphomatosis presenting as brachial plexopathy with involvement of cranial nerves

  • Lee, Hye Jung (Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine) ;
  • Kim, Keun Soo (Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine) ;
  • Song, Pamela (Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Jae-Jung (Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine) ;
  • Sung, Jung-Joon (Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Choi, Kyomin (Department of Neurology, Konkuk University Medical Center) ;
  • Kim, Bohyun (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Cho, Joong-Yang (Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine)
  • Received : 2017.06.23
  • Accepted : 2017.09.25
  • Published : 2018.01.31

Abstract

Neurolymphomatosis (NL) is a rare disease characterized by lymphomatous invasion of the cranial or peripheral nerves by lymphoma. A high suspicion is important due to the various presenting symptoms mandating consideration of many differential diagnoses. We report a case of NL of the cranial nerves and plexus presenting as diplopia, facial palsy, and weakness of the upper and lower limbs in sequence.

Keywords

References

  1. Grisariu S, Avni B, Batchelor TT, van den Bent MJ, Bokstein F, Schiff D, et al. Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report. Blood 2010;115:5005-5011. https://doi.org/10.1182/blood-2009-12-258210
  2. Lagarde S, Tabouret E, Matta M, Franques J, Attarian S, Pouget J, et al. Primary neurolymphomatosis diagnosis and treatment: a retrospective study. J Neurol Sci 2014;342:178-181. https://doi.org/10.1016/j.jns.2014.04.030
  3. Misdraji J, Ino Y, Louis DN, Rosenberg AE, Chiocca EA, Harris NL. Primary lymphoma of peripheral nerve: report of four cases. Am J Surg Pathol 2000;24:1257-1265. https://doi.org/10.1097/00000478-200009000-00009
  4. Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH. Neurolymphomatosis. Neuro Oncol 2003;5:104-115. https://doi.org/10.1215/15228517-5-2-104
  5. Descamps MJ, Barrett L, Groves M, Yung L, Birch R, Murray NM, et al. Primary sciatic nerve lymphoma: a case report and review of the literature. J Neurol Neurosurg Psychiatry 2006;77:1087-1089. https://doi.org/10.1136/jnnp.2006.087577
  6. Matsue K, Hayama BY, Iwama K, Koyama T, Fujiwara H, Yamakura M, et al. High frequency of neurolymphomatosis as a relapse disease of intravascular large B-cell lymphoma. Cancer 2011;117:4512-4521. https://doi.org/10.1002/cncr.26090
  7. Choi YJ, Shin JA, Kim YH, Cha SJ, Cho JY, Kang SH, et al. Neurolymphomatosis of brachial plexus in patients with non-Hodgkin's lymphoma. Case Rep Oncol Med 2013;2013:492329.
  8. Sakai N, Ito-Yamashita T, Takahashi G, Baba S, Koizumi S, Yamasaki T, et al. Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report. J Neurol Surg Rep 2014;75:e62-e66. https://doi.org/10.1055/s-0033-1363505
  9. Sideras PA, Matthews J, Sakib SM, Ofikwu F, Spektor V. Neurolymphomatosis of the peripheral nervous system: a case report and review of the literature. Clin Imaging 2016;40:1253-1256. https://doi.org/10.1016/j.clinimag.2016.08.014
  10. Shree R, Goyal MK, Modi M, Gaspar BL, Radotra BD, Ahuja CK, et al. The diagnostic dilemma of neurolymphomatosis. J Clin Neurol 2016;12:274-281. https://doi.org/10.3988/jcn.2016.12.3.274