한국융합학회논문지 (Journal of the Korea Convergence Society)

  • 제9권6호
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  • Pages.89-98
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  • 2018
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  • 2233-4890(pISSN)
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  • 2713-6353(eISSN)
한국융합학회 (Korea Convergence Society)
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은행잎 추출물 유래 Ginkgetin 및 Isoginkgetin의 융복합 특성 연구

Physicochemical properties of Ginkgetin and Isoginkgetin extracted from Ginko leaves

  • 민경남 (건국대학교 생물공학과)
  • 투고 : 2018.02.06
  • 심사 : 2018.06.20
  • 발행 : 2018.06.28
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초록

은행잎의 Biflavonoid인 ginkgetin과 isoginkgetin을 화장품 소재로 이용 가능성 여부를 확인하기 위해 이를 분리하여 화학 구조 및 물리화학적 특성을 규명하고자 하였다. 음건한 은행나무 단풍잎 1 kg을 순차적으로 ethanol, n-hexane, ethylacetate 및 normal butyl alcohol로 분획 추출하여 최종 ginkgetin과 isoginkgetin을 확보하였다. 두 화합물은 모두 HPLC를 통해 99% 이상 고 순도로 나타났고 MS spectrum을 통한 분자량은 566, 분자식은 $C_{32}H_{22}O_{10}$로 동일한 이성질체적 구조를 나타냈다. UV spectrum으로 flavonoid의 골격과 NMR로 aromatic proton의 존재와 탄소 수 및 구성비를 측정한 결과 문헌에 보고된 flavonoid 화합물의 정보와 일치하였다.

To confirm the feasibility as raw materials for cosmetic formulation, ethanol, n-hexane, ethylacetate and normal butyl alcohol were extracted from 1kg of Ginko leaves. Ultimately, investigated chemical structure and physicochemical properties of ginkgetin and isoginkgetin. The purity of those two components have been evaluated higher than 99%. They are isomers with molecular weight as 566 and a molecular formular, $C_{32}H_{22}O_{10}$. Flavonoid's frame and NMR spectrum exhibited the existence of aromatic proton and the proper ratio of the carbon, which were expected structures exactly corresponded to the reported references.

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참고문헌

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