The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Lipidomic analysis of plasma lipids composition changes in septic mice

  • Ahn, Won-Gyun (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University) ;
  • Jung, Jun-Sub (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University) ;
  • Song, Dong-Keun (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University)
  • Received : 2017.11.11
  • Accepted : 2018.04.06
  • Published : 2018.07.01
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Abstract

A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), compounds known to have beneficial effects in CLP, on the sepsis-induced plasma lipid changes were also examined. Among the 147 plasma lipid species from 13 lipid subgroups (fatty acid [FA], LPA, LPC, lysophosphatidylethanolamine [LPE], phosphatidic acid [PA], phosphatidylcholine [PC], phosphatidylethanolamine [PE], phosphatidylinositol [PI], monoacylglyceride [MG], diacylglyceride [DG], triacylglyceride [TG], sphingomyelin [SM], and ceramide [Cer]) analyzed in this study, 40 and 70 species were increased, and decreased, respectively, in the CLP mice. Treatments with LPC and LPA affected 14 species from 7 subgroups, and 25 species from 9 subgroups, respectively. These results could contribute to finding the much needed reliable biomarkers of sepsis.

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References

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