Journal of the Korea Institute of Military Science and Technology (한국군사과학기술학회지)

The Korea Institute of Military Science and Technology (한국군사과학기술학회)
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Biomarkers for Combat-Related Stress and Fatigue-Mitigating Drugs Discovery

전투 스트레스 및 피로 완화 약물 탐색을 위한 생체지표

  • Koo, Hyojin (Department of Basic Science, Air Force Academy) ;
  • Kim, Chang Yul (Department of Occupational Health, Catholic University of Daegu) ;
  • Kim, Yeonkyung (Department of Occupational Health, Catholic University of Daegu) ;
  • Sin, So Jung (Department of Occupational Health, Catholic University of Daegu) ;
  • Cheon, Kicheol (The 5th Research and Development Institute, Agency for Defense Development) ;
  • Kim, Dongsoo (Department of Basic Science, Air Force Academy)
  • 구효진 (공군사관학교 기초과학과) ;
  • 김창열 (대구가톨릭대학교 산업보건학과) ;
  • 김연경 (대구가톨릭대학교 산업보건학과) ;
  • 신소정 (대구가톨릭대학교 산업보건학과) ;
  • 천기철 (국방과학연구소 제5기술연구본부) ;
  • 김동수 (공군사관학교 기초과학과)
  • Received : 2017.09.29
  • Accepted : 2018.02.09
  • Published : 2018.04.05
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Abstract

Psychological stress and physical fatigue, such as anxiety, fear, sleep disturbance, etc., caused by exposure to the war, can lead to post-traumatic stress syndrome(PTSD) or war syndrome. The military has also prepared for drug use to minimize war syndrome and preserve combat strength. However, efforts to prevent war syndrome are still lacking. This study was conducted to identify biomarkers that can track psychophysiological changes. Psychophysiological changes associated with PTSD can be divided into four main categories. The four categories are behavioral changes, changes in brain cognition, neuroimmunological changes, and changes in innate immunity. This study suggest that biomarker profile can be made by the distance moved and the anxiety-like behavior in the open field for behavior category, brain BDNF levels in the brain cognition category, serum corticosterone in the neuroimmunology category, and inflammatory cytokine levels in the innate immunity category.

Keywords

References

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