대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제32권2호
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  • Pages.43-63
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  • 2018
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  • 1226-8038(pISSN)
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  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
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소아 야뇨의 한약치료에 대한 임상연구 동향 -중의학 논문을 중심으로-

Review of Clinical Researches for Herbal Medicine Treatment on Nocturnal Enuresis in Children

  • 신혜진 (경희대학교 대학원 임상한의학과 소아과학교실, 강동경희대학교병원 한방소아과) ;
  • 이보람 (경희대학교 대학원 임상한의학과 소아과학교실, 강동경희대학교병원 한방소아과) ;
  • 이지홍 (경희대학교 대학원 임상한의학과 소아과학교실, 강동경희대학교병원 한방소아과) ;
  • 장규태 (경희대학교 대학원 임상한의학과 소아과학교실, 강동경희대학교병원 한방소아과)
  • Shin, Hye Jin (Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University, Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Lee, Boram (Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University, Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Lee, Jihong (Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University, Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Chang, Gyu Tae (Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University, Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong)
  • 투고 : 2018.04.26
  • 심사 : 2018.05.15
  • 발행 : 2018.05.31
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초록

Objectives The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of nocturnal enuresis in children by analyzing randomized controlled trials conducted in China. Methods We searched literatures from China National Knowledge Infrastructure published up to 19 January, 2018. Selected literatures were collected and analyzed in order of publication year, and then demographic information, treatment method, duration of illness, duration of treatment, follow-up period, outcome measurement and adverse events. Results A total of 34 studies were selected for the analysis. In most studies, the total efficacy of the treatment group was reported to be higher than that of the control group, and the recurrence rate and complete cure rate were also found to be more effective in the herbal medicine treatment group. The most frequently used medical herb was Alpiniae Fructus (益智仁), and the use of medical herbs belong to tonifying yang (補陽藥), tonifying qi (補氣藥), and astringing essence strengthening collapse medicine (澁精縮尿止帶藥) were relatively high. The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group. Conclusions This study showed that a herbal medicine treatment can be effective and safe option for treating pediatric nocturnal enuresis. However, additional well-designed clinical studies need to be performed to establish a basis.

키워드

참고문헌

  1. Neveus T, von Gontard A, Hoebeke P, Hjalmas K, Bauer S, Bower W, Jorgensen TM, Rittig S, Walle JV, Yeung CK, Djurhuus JC. The standardization of terminology of lower urinary tract function in children and adolescents: report from the standardization commit- tee of the International Children's Continence Society. J Urol. 2006;176(1):316-24.
  2. von Gontard A, Mauer-Mucke K, Pluck J, Berner W, Lehmkuhl G. Clinical behavioral problems in day- and night-wetting children. Pediatr Nephrol. 1999;13(8): 662-7. https://doi.org/10.1007/s004670050677
  3. Wan J, Greenfield S. Enuresis and common voiding abnormalities. Pediatr Clin North Am. 1997;44(5): 1117-31. https://doi.org/10.1016/S0031-3955(05)70550-2
  4. Forsythe WI, Redmond A. Enuresis and spontaneous cure rate: study of 1129 enuretics. Arch Dis Child. 1974;49(4):259-63. https://doi.org/10.1136/adc.49.4.259
  5. Wille S. Comparison of desmopressin and enuresis alarm for nocturnal enuresis. Arch Dis Child. 1986;61(1):30-3. https://doi.org/10.1136/adc.61.1.30
  6. Glazener CM, Evans JH, Peto RE. Alarm interventions for nocturnal enuresis in children. Cochrane Database Syst Rev. 2005;18(2):CD002911.
  7. Heo J. Donguibogam. Seoul: Nam San Dang Publishing Co. 2014:173-4.
  8. Cho HJ, Lee JY, Kim DK. The clinical study on the effect of radix ephedrae on the nocturnal enuresis in Korean children. J Korean Orient Pediatr. 2001;15(1):155-64.
  9. Oh JY, Chang GT, Kim JH. Three cases report about enuretic children treated with electro-acupuncture on Zhongji (CV3), Guanyuan (CV4). J Korean Orient Pediatr. 2005;19(1):103-15.
  10. Ju BH, Jang JH, Jeong MJ, Lee SY. The clinical effect of Gikwuibosin-tang on nocturnal enuresis. J Korean Orient Pediatr. 2006;20(2):139-46.
  11. Kim JY, Lim HW, Kim JH, Kwon K, Kim JH. The five cases report about enuretic children with moxa bucket moxibustion on Gwanwon (CV4). J Korean Orient Pediatr. 2010;24(2):159-68.
  12. Jeon BR, Min SY, Kim JH. Case study of nocturnal enuresis in two children by focusing sleep-wake transition. J Pediatr Korean Med. 2016;30(1):1-8. https://doi.org/10.7778/jpkm.2016.30.1.001
  13. Oh JY, Chang GT, Kim JH. A follow-up study of enuretic children. J Korean Orient Pediatr. 2004;18(1): 179-91.
  14. Chang GT. Acupuncture clinical trial study for treatment of nocturnal enuresis. J Korean Orient Pediatr. 2003; 17(2):213-24.
  15. Oh JY, Chang GT, Kim JH. Acupuncture for childhood nocturnal enuresis in traditional Chinese medical journals. J Korean Orient Pediatr. 2005;19(1):83-102.
  16. Noh YH, Kim KB. Recent research on treatments of childhood nocturnal enuresis - within acupuncture, mox- ibustion, psychotherapy and chiropractic. J Korean Orient Pediatr. 2011;25(3):1-11.
  17. Sun XJ, Chang K, Zhang FH, Zhang L. Systematic evaluation of the treatment for enuresis in children with the kidney-nourishing herbs for internal use. Chin Pediatr Integr Tradit West Med. 2011;3(6):481-7.
  18. Yu P, Zhao YS, Ma R, Hu SY, Zhong CL, Zhao JS. Systematic evaluation of literatures of TCM on nocturnal enuresis in children. Chin J Tradit Chin Med. 2012; 27(7):1818-22.
  19. Wang ZY, Du K, Li C, Xi Q, Zhang F. Guideline for TCM pediatrics clinical diagnosis and treatment.infantile enuresis (amendment). J Pediatr Tradit Chin Med. 2018;14(1):4-8.
  20. Jin HR. Clinical observation on infantile enuresis treated by Seunggichukcheontang. Zhejiang J Integr Tradit Chin West Med. 2000;10(2):110-1.
  21. Lin XQ, Sun KQ. Mahuang decoction for treating 56 cases of pediatric enuresis. J Pract Tradit Chin Med. 2000;16(1):24-5.
  22. Teng YL, Lu XY, Da CH. Clinical observation on 50 cases of enuresis in children treated by Yunyoryeongbang. J New Chin Med. 2002;34(12):27-8.
  23. Zhang ZJ. Treating 82 cases of enuresis in children with modified Ojayeonjonghwan. Chin Folk Med. 2002;10(6):52.
  24. Wang FD. Treatment of 38 cases of enuresis with Ijigyotaetang. J Pract Tradit Chin Med. 2003;19(1):18-9.
  25. Chen JW, Cai Y. Clinical observation on 44 cases of primary enuresis treated by Yunyobang. Mod J Integrat Tradit Chin West Med. 2003;12(4):386-7.
  26. Wang LM, Mei M, Guo L. Clinical observation on 34 children with primary enuresis treated by Gaehaphwan. Henan Tradit Chin Med. 2004;24(10):45.
  27. Chen X. Treatment of 44 cases of pediatric enuresis with TCM. J Mil Med Southwest China. 2004;6(4):37.
  28. Zhu RM, Huang YL, Fu GX. Clinical observation on children's enuresis treated by Seonpyeonsinjiyubang. Chin Hosp Pharm J. 2005;25(4):359-60.
  29. Xia Y. Treatment of pediatric enuresis in 38 cases with Onhaseungjunggaesangtang. J Pract Tradit Chin Med. 2005;21(10):591.
  30. Li ZZ. Clinical observation on treatment of functional enuresis in children with self-made Yunyobang. Chin J Pract Village Doc. 2006;13(3):37-8.
  31. Yi JY, Yu HY. Clinical observation on pediatric enuresis treated by Jichang powder. Gansu J Tradit Chin Med. 2007;20(11):38.
  32. Chen YJ, Wang ZY. Clinical observation on 32 cases of infant enuresis treated by Gosinchuknyotang. China Chin Med Technol. 2007;14(4):286-7.
  33. Li XY, Wei PX. Treatment of 33 cases of pediatric enuresis with modified Tosajahwan. China Pract Med. 2008;3(3):161.
  34. He XT. Clinical observation on treatment of pediatric enuresis with Onsingeonbijiyutang. J Sichuan Tradit Chin Med. 2008;26(5):84-5.
  35. Wang ZO. Treatment of 40 cases of pediatric enuresis with Seoakchuknyosan. Mod Tradit Chin Med. 2009; 29(5):52-3.
  36. Gao J, Wang Q. Treatment of 30 cases of pediatric enuresis with modified Olyeongsangami. Pract Clin Med. 2010;11(6):77-8.
  37. Cheng YM, Ren XH, Ku Y. Treatment of 30 cases of pediatric enuresis with herbal free granule formula. Guid J Tradit Chin Med Pharm. 2010;16(1):33-4.
  38. Su W, Hu AX, Xu HX, Du H. Clinical observation on Yunyobang treating pediatric enuresis with kidney yang deficiency. Hubei J Tradit Chin Med. 2010;32(2): 54-5.
  39. Chen XF, Cho SP, Zheng YL. Treatment of 56 cases of pediatric enuresis with combination of traditional Chinese and Western medicine. Chin J Exp Tradit Med Formul. 2011;17(14):77-8.
  40. Cao H. Treatment of 30 cases of pediatric enuresis with combination of traditional Chinese and Western medicine. Chin Med Mod Dist Educ China. 2012;10(3): 42-3.
  41. Peng YK. Clinical observation on 32 cases of pediatric enuresis treated with Guyuan Zhigen decoction. Yunnan Chin Med J. 2013;34(2):31.
  42. Luo XY. Clinical study on the method of percolating the lung to opening the orifices for treatment of children with enuresis (lung depression and Du-vessel stagnation). Master's thesis of Chengdu Univ Tradit Chin Med. 2014.
  43. Li L. Treatment of 63 cases of pediatric enuresis with Quanquan capsules combined with bladder training. Guid China Med. 2014;12(14):282.
  44. Lin LJ, Li YH, Xiao XY, Deng HY. Analysis of Buzhongyiqi pills with Mahuang granules in the treat- ment of lung and spleen deficiency in children with primary nocturnal enuresis effect. Chin J Pharm Econ. 2014;(5):42-3.
  45. Lin LJ, Wei Q, Deng HY. Clinical observation on primary nocturnal enuresis treated by Mahuang granules com- bined with Quanquan capsules in lower belly weakness and coldness children. J New Chin Med. 2014;46(3): 114-6.
  46. Yan PF, Li XJ. Clinical observation on treatment of pediatric enuresis with Onsinyunyotang combined with desmopressin. 2014;26(12):1253-4.
  47. Chen ZM, Ju L. Clinical observation on treatment of 48 cases of enuresis of children with kidney yang defi- ciency assisted by Bushenzhige decoction. J New Chin Med. 2014;46(11):137-8.
  48. Hu P. Clinical efficacy analysis of ephedra treating pediatric enuresis. Guid China Med. 2014;12(12):265-6.
  49. Liu ZH, Zhang GF, Zhang B, Li M. Clinical observation on 32 cases of primary enuresis in children treated with combination of traditional Chinese and Western medicine. J Sichuan Tradit Chin Med. 2015;33(3):117-8.
  50. Zhao LZ, Liu S, Zhang LL. Observation on 50 cases of primary enuresis in children treated with combination of traditional Chinese and Western medicine. J Pract Tradit Chin Med. 2015;31(1):45-6.
  51. Guo X. Clinical efficacy of Shengqizhuangyang therapy in treatment of infantile enuresis. Acta Chin Med. 2016;31(3):443-5.
  52. Li LB. Clinical study on treatment of primary nocturnal enuresis in children with traditional Chinese and Western medicine. Asia Pac Tradit Med. 2017;13(8):121-2.
  53. Yi F. Clinical observation on treatment of pediatric enuresis with Zhige decoction combined with dry bed training. Mod Tradit Chin Med. 2017;37(4):48-50.
  54. National Oriental Medicine College Collaborative Textbook Compilation Committee. Herbalogy. Seoul: Young Lim Publishing Co. 2011:10-8, 398, 580-1, 609-10.
  55. Norgaard JP, Pedersen EB, Djurhuus JC. Diurnal antidiuretic hormone levels in enuretics. J Urol. 1985; 134(5):1029-31. https://doi.org/10.1016/S0022-5347(17)47581-1
  56. Weaver A, Dobson P. Nocturnal enuresis in children. J Fam Health Care. 2007;17(5):159-61.
  57. Yeung CK, Sit FK, To LK, Chiu HN, Sihoe JD, Lee E, Wong C. Reduction in nocturnal functional bladder capacity is a common factor in the pathogenesis of re- fractory nocturnal enuresis. BJU Int. 2002;90(3):302-7. https://doi.org/10.1046/j.1464-410X.2002.02884.x
  58. Mueller SR. Development of urinary control in children: some aspects of the cause and treatment of primary enuresis. J Am Med Assoc. 1960;172:1256-61. https://doi.org/10.1001/jama.1960.03020120034007
  59. Bakwin H. The genetics of enuresis. In: Kolvin I, MacKeith RC, Meadow SR, editors. Bladder control and enuresis. London: William Heinemann Medical Books. 1973:73-7.
  60. Ahn HS, Shin HY. Hongchangui Pediatrics. Seoul: Mirae N. 2016:997-9.
  61. Kim KB, Kim DG, Kim YH, Kim JH, Min SY, Park EJ, Baek JH, Sung HK, Yu SA, Lee SY, Lee JY, Lee HJ, Chang GT, Jeong MJ, Chai JW, Cheon JH, Han YJ, Han JK. Hanbangsoacheongsonyeonuihak (ha). Seoul: Ui Sung Dang Publishing Co. 2015:167-70.
  62. Thiedke CC. Nocturnal enuresis. Am Fam Physician. 2003;67(7):1499-506.
  63. Kim DS, Oh CH, Lee SR. Effects of Chukchunhwan-ex- tracts on the urine metabolism in rat. Korean J Orient Physiol Pathol. 2002;16(2):257-61.
  64. Yang SS. Clinical oriental medicine II. Seoul: Beob In Publishing Co. 1999:62-79.
  65. Jang IS, Yang CS, Hwang EH. The need for clinical practice guidelines in usage of Mahuang in weight loss. J Soc Korean Med Obes Res. 2007;7(1):23-9.
  66. Ryu HC, Shin JG. A study on proper dosage of Ma-huang. J Korean Med Assoc Clin Sanghan-Geumgwe. 2013; 5(1):101-11.
  67. Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagne J. Efficacy and safety of ephedra and Ma-huang for weight loss and athletic performance: a meta-analysis. JAMA. 2003; 289(12):1537-45. https://doi.org/10.1001/jama.289.12.1470
  68. O'Flynn N. Nocturnal enuresis in children and young people: NICE clinical guideline. Br J Gen Pract. 2011;61(586):360-2. https://doi.org/10.3399/bjgp11X572562
  69. Deshpande AV, Caldwell PH, Sureshkumar P. Drugs for nocturnal enuresis in children (other than desmo- pressin and tricyclics). Cochrane Database Syst Rev. 2012;12:CD002238.
  70. Jalkut MW, Lerman SE, Churchill BM. Enuresis. Pediatr Clin North Am. 2001;48(6):1461-88. https://doi.org/10.1016/S0031-3955(05)70386-2
  71. Glazener CM, Evans JH, Peto RE. Alarm interventions for nocturnal enuresis in children. Cochrane Database Syst Rev. 2005;18(2):CD002911.
  72. Neveus T. Oxybutynin, desmopressin and enuresis. J Urol. 2001;166(6):2459-62. https://doi.org/10.1016/S0022-5347(05)65616-9