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Imaging Findings of Pancreatic Solid Pseudopapillary Neoplasm with High-Grade Malignant Transformation: Focusing on Diffusion-Weighted Imaging and Normalized Apparent Diffusion Coefficient Values

고등급 악성전환을 보인 고형 가유두상 종양의 영상소견: 확산강조영상 및 표준화 현성확산계수값

  • Kang, Ka Ram (Department of Radiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Shin, Ok Ran (Department of Hospital Pathology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Su Lim (Department of Radiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Ku, Young Mi (Department of Radiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 강가람 (가톨릭대학교 의과대학 의정부성모병원 영상의학과) ;
  • 신옥란 (가톨릭대학교 의과대학 의정부성모병원 병리과) ;
  • 이수림 (가톨릭대학교 의과대학 의정부성모병원 영상의학과) ;
  • 구영미 (가톨릭대학교 의과대학 의정부성모병원 영상의학과)
  • Received : 2017.07.20
  • Accepted : 2017.09.18
  • Published : 2018.03.01

Abstract

Solid pseudopapillary neoplasm (SPN) of the pancreas is an uncommon neoplasm characterized by low-grade malignant potential and uncertain histogenesis, and usually afflicts relatively young women. The tumors typically manifest as well-marginated, mixed density lesions consisting of a solid peripheral and central cystic component in conjunction with hemorrhagic foci. SPN with apparent high-grade malignant transformation is a rare histologic variant. Herein, we report a rare case of SPN with high-grade malignant transformation diagnosed in a 75-year-old female, with emphasis on differential diagnoses and role of normalized ADC values. SPN with malignant transformation should be included in the differential diagnosis in cases of mixed solid and cystic masses with hemorrhagic components, irregular margin and lower normalized apparent diffusion coefficient (ADC) values in an elderly female patient, as was the case discussed below.

췌장의 고형 가유두상 종양은 그 조직 발생에 대해서는 명확히 알려져 있지 않지만, 비교적 낮은 악성도를 보이는 종양으로 주로 젊은 여성에서 호발한다. 일반적으로 경계가 좋고 주변부는 고형 성분으로, 중심부는 출혈성 병소를 포함하는 낭성 성분으로 구성된 비균일한 음영을 가지는 병변으로 보인다. 고등급 악성전환을 보이는 고형 가유두상 종양은 흔하지 않은 변이 형태이다. 저자들은 75세 여성에서 고등급 악성전환을 보인 고형 가유두상 종양의 증례를 보고하고, 감별진단을 하는 데에 있어서 표준화 현성확산계수값의 유용성에 대해 알리고자 한다. 본 증례처럼 고령의 여성에서 명확하지 않은 경계를 보이며, 주위 조직으로의 침범소견을 보이고 출혈성 병소를 포함하며 낮은 표준화 현성확산계수값을 보이는 고형성분이 혼합된 경우, 고형 가유두상 종양의 악성전환을 감별에 포함해야 한다.

Keywords

References

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