Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Thyroid Hyalinizing Trabecular Tumor Mistaken for Papillary Carcinoma in Aspiration Cytology

흡인 세포검사에서 유두상 암종으로 오인된 갑상선 유리질 소주형 종양 1예

  • Hong, Seok Jung (Department of Otolaryngology-Head and Neck Surgery, Veterans Health Service Medical Center) ;
  • Kim, Eun Ju (Department of Pathology, Veterans Health Service Medical Center) ;
  • Kim, Seung Woo (Department of Otolaryngology-Head and Neck Surgery, Veterans Health Service Medical Center)
  • 홍석정 (중앙보훈병원 이비인후과) ;
  • 김은주 (중앙보훈병원 병리과) ;
  • 김승우 (중앙보훈병원 이비인후과)
  • Received : 2018.02.24
  • Accepted : 2018.03.27
  • Published : 2018.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Hyalinizing trabecular tumor (HTT) of the thyroid gland is a rare neoplasm and only less than 100 cases have been reported so far. It is characterized by hyalinizing stroma with trabecular growth pattern and has an indolent clinical course. Because of its histologic features, it is frequently misdiagnosed as papillary or medullary carcinoma in fine needle aspiration cytologic findings. The tumor is benign or low malignant potential and thyroid lobectomy is recommended for adequate treatment. We recently experienced a case of thyroidal HTT in a 57-year-old man, who presented with a right thyroid nodule that was suspicious of papillary carcinoma in aspiration cytology. We report the unique and rare disease entity with brief literature review.

Keywords

References

  1. Jang KY, Kim JH, Chung MJ, Moon WS, Kang MJ. Hyalinizing trabecular carcinoma of the thyroid gland: A report of two cases. Korean J Pathol. 2000;34:318-322.
  2. Barsu C, Barsu M. Medico-historical overview and histopathological comments about a hyalinizing trabecular tumor case of thyroid gland. Rom J Morphol Embryol. 2014;55:989-992.
  3. Howard BE, Gnagi SH, Ocal IT, Hinni ML. Hyalinizing trabecular tumor masquerading as papillary thyroid carcinoma on fine-needle aspiration. ORL J Otorhinolaryngol Relat Spec. 2013;75:309-313. https://doi.org/10.1159/000355291
  4. Lee HK, Kim HS, Hur MH, Kang SS, Lee JH, Lee SK. Hyalinizing trabecular adenoma of thyroid gland. J Korean Surg Soc. 2002;62:87-90.
  5. Park KS, Kim SW, Min HS, Han WS, Noh DY, Park SH, et al. Hyalinizing trabecular adenoma of thyroid. J Korean Surg Soc. 2003;65:572-575.
  6. Seo JH, Kim JP, Woo SH. A case of hyalinizing trabecular adenoma of the thyroid gland. Int J Thyroidol. 2017;10:46-49. https://doi.org/10.11106/ijt.2017.10.1.46
  7. Yi KI, Ann S, Park DY, Lee JC, Lee BJ, Wang SG, et al. False-positive cytopathology results for papillary thyroid carcinoma: A trap for thyroid surgeons. Clin Otolaryngol. 2017;42:1153-1160. https://doi.org/10.1111/coa.12840
  8. Jang EK, Song DE, Gong G, Baek JH, Choi YM, Jeon MJ, et al. Positive cytology findings and a negative histological diagnosis of papillary thyroid carcinoma in the thyroid: Is it a false-positive cytology or a disappearing tumor? Eur Thyroid J. 2013;2:203-210.
  9. Jang H, Park CK, Son EJ, Kim EK, Kwak JY, Moon HJ, et al. Hyalinizing trabecular tumor of the thyroid: Diagnosis of a rare tumor using ultrasonography, cytology, and intraoperative frozen sections. Ultrasonography. 2016;35:131-139. https://doi.org/10.14366/usg.15054
  10. Sung SY, Shen HY, Hsieh CB, Duh QY, Su TF, Chan DC, et al. Hyalinizing trabecular tumor of thyroid: Does frozen section prevent unnecessarily aggressive operation? six new cases and a literature review. J Chin Med Assoc. 2014;77:573-577. https://doi.org/10.1016/j.jcma.2014.08.006
  11. Lee S, Hong S, Koo JS. Immunohistochemical subclassification of thyroid tumors with a prominent hyalinizing trabecular pattern. APMIS. 2011;119:529-536. https://doi.org/10.1111/j.1600-0463.2011.02762.x
  12. Papotti M, Volante M, Giuliano A, Fassina A, Fusco A, Bussolati G, et al. RET/PTC activation in hyalinzing trabecular tumors of the thyroid. Am J Surg Pathol. 2000;24:1615-1621. https://doi.org/10.1097/00000478-200012000-00004
  13. Carney JA, Hirokawa M, Lloyd RV, Papottie M, Sebo TJ. Hyalinzing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol. 2008;32:1877-1889. https://doi.org/10.1097/PAS.0b013e31817a8f1b