DOI QR코드

DOI QR Code

Preparation and Properties of Hydroxyapatite/Methylcellulose for Bone Graft

  • Tak, Woo-Seong (Department of Nano Fusion Technology, Pusan National University) ;
  • Kim, Dong-Jun (Department of Nano Fusion Technology, Pusan National University) ;
  • Ryu, Su-Chak (Department of Nanomechatronics, Pusan National University)
  • 투고 : 2017.11.01
  • 심사 : 2018.03.16
  • 발행 : 2018.03.31

초록

Although many bone graft materials have been developed, powder graft materials are somewhat difficult to use in surgery. To solve this problem, a bone graft material in the form of a viscous paste was prepared. Hydroxyapatite was used as a bone graft material, and methyl cellulose was used to impart viscosity. Three cases of samples were prepared, and freeze-dried block type and sintered specimens were made from the paste. The recrystallization of the graft material in a simulated body fluid and the degree of graft adhesion with a tooth were observed by scanning electron microscopy (SEM). The test for cytotoxicity was carried out and the sample was grafted into the back of a mouse to confirm the presence or absence of side effects in the animal's body. Based on these investigations, composites of this type are expected to be applicable for bone grafts.

키워드

참고문헌

  1. T. Alberektsson and C. Johansson, "Osteoinduction, Osteoconduction Andosseointegration," Eur. Spine J., 10 s96-101 (2001). https://doi.org/10.1007/s005860100282
  2. J. B. Park and J. D. Bronzino, Biomaterials: Principles and Application; Boca Raton: CRC Press, 2000.
  3. R. C. Elkincs, P. E. Dawson, S. Goldstein, S. P. Walsh, and K. S. Black, "Decellularized Human Valve Allografts," Ann. Thorac Surg., 71 S428-32 (2001). https://doi.org/10.1016/S0003-4975(01)02503-6
  4. A. Lichtenberg, T. Breymann, S. Cebotari, and A. Haverich, "Cell Seeded Tissue Engineered Cardiac Valves Based on Allograft and Xenograft Scaffolds," Prog. Pediatr. Cardiol., 21 [2] 211-17 (2006). https://doi.org/10.1016/j.ppedcard.2005.11.008
  5. P. V. Giannoudis, H. Dinopoulos, and E. Tsiridis, "Bone substitutes: An update," Injury, 36 S20-7 (2005).
  6. S. T. Kao and D. D. Scott, "A Review of Bone Substitutes," Oral Maxillofac. Surg. Clin. North Am., 19 [4] 513-21 (2007). https://doi.org/10.1016/j.coms.2007.06.002
  7. F. Matassi, L. Nistri, D. C. Paez, and M. Innocenti, "New Biomaterials for Bone Regeneration," Clin. Cases Miner. Bone Metab., 8 [1] 21-4 (2011).
  8. A. R. Vaccaro, "The Role of the Osteoconductive Scaffold in Synthetic Bone Graft," Orthopedics, 25 s571-78 (2002).
  9. A. A. Campbell, "Bioceramics for Implant Coatings," Materialstoday, 6 [11] 26-30 (2003).
  10. T. V. Thamaraiselvi and S. Rajeswari, "Biological Evaluation of Bioceramic Materials," Trends Biomater. Artif. Organs, 18 [1] 9-17 (2004).
  11. P. N. de Aza, A. H. de Aza, and S. de Aza, "Crystalline Bioceramic Materials," ChemInform, 44 [3] 135-45 (2005).
  12. D. Haverty, S. A. M. Tofail, K. T. Stanton, and J. B. Mcmonagle, "Structure and Stability of Hydroxyapatite: Density Functional Calculation and Rietveld Analysis," Phys. Rev. B, 71 [9] 094103 (2005). https://doi.org/10.1103/PhysRevB.71.094103
  13. G. Ma and X. Y. Liu, "Hydroxyapatite: Hexagonal or Monoclinic?," Cryst. Growth Des., 9 [7] 2991-94 (2009). https://doi.org/10.1021/cg900156w
  14. J. Reyes-Gasga, E. L. Martinez-Pineiro, and E. F. Bres, "Crystallographic Structure of Human Tooth Enamel by Electron Microscopy and X-Ray Diffraction: Hexagonal or Monoclinic?," J. Microsc., 248 [1] 102-9 (2012). https://doi.org/10.1111/j.1365-2818.2012.03653.x
  15. M. R. Wells, K. Kraus, D. K. Batter, D. G Blunt, J. Weremowitz, S. E. Lynch, H. N. Antoniades, and H. A. Hansson, "Gel Matrix Vehicles for Growth Factor Application in Nerve Gap Injuries Repaired with Tubes: A Comparison of Biomatrix, Collagen, and Methylcellulose," Exp. Neurol., 146 [2] 395-402 (1997). https://doi.org/10.1006/exnr.1997.6543
  16. S. Ghanaati, M. Barbeck, U. Hilbig, C. Hoffmann, R. E. Unger, R. A. Sader, F. Peters, and C. J. Kirkpatrick, "An Injectable Bone Substitute Composed of Beta-Tricalcium Phosphate Granules, Methylcellulose and Hyaluronic Acid Inhibits Connective Tissue Influx into its Implantation Bed in Vivo," Acta Biomater., 7 [11] 4018-28 (2011). https://doi.org/10.1016/j.actbio.2011.07.003
  17. I. Toda, N. Shinozaki, and K. Tsubota, Hydroxypropyl Methylcellulose for the Treatment of Severe Dry Eye Associated with Sjogren's Syndrome," Cornea, 15 [2] 120-28 (1996). https://doi.org/10.1097/00003226-199603000-00003
  18. H. Shibata, T. Yokoi, T. Goto, I. Y. Kim, M. Kawashita, K. Kikuta, and C. Ohtsuki, "Behavior of Hydroxyapatite Crystals in a Simulated Body Fluid: Effects of Crystal Face," J. Ceram. Soc. Jpn., 121 [1417] 807-12 (2013). https://doi.org/10.2109/jcersj2.121.807

피인용 문헌

  1. Post-operative Pain and Antibacterial Efficacy of Silver Nanoparticles Formulations Intracanal Medication: A Randomized Controlled Clinical Study vol.9, pp.4, 2018, https://doi.org/10.3889/oamjms.2021.6503