Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Negative myoclonus associated with pregabalin

  • Park, Kwan-Do (Department of Neurology, Yeungnam University College of Medicine) ;
  • Kim, Min-Ku (Department of Neurology, Yeungnam University College of Medicine) ;
  • Lee, Se-Jin (Department of Neurology, Yeungnam University College of Medicine)
  • Received : 2018.03.20
  • Accepted : 2018.05.31
  • Published : 2018.12.31
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Abstract

Negative myoclonus (NM) is a jerky, shock-like involuntary movement caused by a sudden, brief interruption of muscle contraction. An 80-year-old man presented with multifocal NM and confusion. Two days before the onset of NM, he commenced the intake of pregabalin at a dose of 150 mg/day for neuropathic pain. His NM resolved completely and mental status improved gradually after the administration of lorazepam intravenously and the discontinuation of pregabalin. Our study suggests that pregabalin can cause NM even in patients without a history of seizures.

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References

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  1. Pregabalin-associated movement disorders: A literature review vol.6, pp.2, 2018, https://doi.org/10.4103/bc.bc_57_19
  2. Electrophysiological characteristics and anatomical differentiation of epileptic and non-epileptic myoclonus vol.57, pp.1, 2018, https://doi.org/10.1186/s41983-021-00374-5