Health Policy and Management (보건행정학회지)

Korean Academy of Health Policy and Management (한국보건행정학회)
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Assessing Seasonality of Acute Febrile Respiratory Tract Infections and Medication Use

인플루엔자 등 급성 호흡기계 질환과 의약품 사용의 계절적 상관성 분석

  • Park, Juhee (Pharmaceutical and Medical Device Research Team, Department of Research, Health Insurance Review and Assessment Service) ;
  • Choi, Won Suk (Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine) ;
  • Lee, Hye-Yeong (Pharmaceutical and Medical Device Research Team, Department of Research, Health Insurance Review and Assessment Service) ;
  • Kim, Kyoung-Hoon (Pharmaceutical and Medical Device Research Team, Department of Research, Health Insurance Review and Assessment Service) ;
  • Kim, Dong-Sook (Pharmaceutical and Medical Device Research Team, Department of Research, Health Insurance Review and Assessment Service)
  • 박주희 (건강보험심사평가원 연구조정실 의약기술연구팀) ;
  • 최원석 (고려대학교 의과대학 내과학교실 감염내과) ;
  • 이혜영 (건강보험심사평가원 연구조정실 의약기술연구팀) ;
  • 김경훈 (건강보험심사평가원 연구조정실 의약기술연구팀) ;
  • 김동숙 (건강보험심사평가원 연구조정실 의약기술연구팀)
  • Received : 2018.07.31
  • Accepted : 2018.08.21
  • Published : 2018.12.31
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Abstract

Background: Monitoring appropriate medication categories can provide early warning of certain disease outbreaks. This study aimed to present a methodology for selecting and monitoring medications relevant to the surveillance of acute respiratory tract infections, such as influenza. Methods: To estimate correlations between acute febrile respiratory tract infection and some medication categories, the cross-correlation coefficient (CCC) was used and established. Two databases were used: real-time prescription trend of antivirals, anti-inflammatory drugs, antibiotics using Drug Utilization Review Program between 2012 and 2015 and physicians' number of encounters with acute febrile respiratory tract infections such as influenza outbreaks using the national level health insurance claims data. The seasonality was also evaluated using the CCC. Results: After selecting six candidate diseases that require extensive monitoring, influenza with highly specific medical treatment according to the health insurance claims data and its medications were chosen as final candidates based on a data-driven approach. Antiviral medications and influenza were significantly correlated. Conclusion: An annual correlation was observed between influenza and antiviral medications, anti-inflammatory drugs. Suitable models should be established for syndromic surveillance of influenza.

Keywords

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Figure 1. The process of research.

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Figure 2. Seasonality of ILI and medication use. (A) Anti-inflammatory drugs. (B) Cough remedy. (C) Antibiotics. (D) Anti-viral medications. ILI, influenza-like illness.

Table 1. The infectious disease and treatment

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Table 2. The specifcity of treatment2)

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