대한간호학회지 (Journal of Korean Academy of Nursing)

한국간호과학회 (Korean Society of Nursing Science)
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항암화학요법 관련 말초신경병증에 적용한 비약물적 중재의 효과: 체계적 문헌고찰 및 메타분석

Effectiveness of Non-Pharmacologic Interventions in Chemotherapy Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

  • 오복자 (삼육대학교 간호학과) ;
  • 김유림 (삼육대학교 물리치료학과.재활보건과학연구소)
  • Oh, Pok-Ja (Department of Nursing, Sahmyook University) ;
  • Kim, You Lim (Department of Physical Therapy.Laboratory of Rehabilitation & Health Science, Sahmyook University)
  • 투고 : 2017.11.14
  • 심사 : 2018.03.14
  • 발행 : 2018.04.30
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초록

Purpose: This study was conducted to evaluate the effectiveness of non-pharmacologic interventions in chemotherapy-induced peripheral neuropathy (CIPN). Methods: PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL, and several Korean databases (Until August 2017) were searched. The main search strategy combined terms for peripheral neuropathy and presence of neoplasms. The risk of bias was assessed using the Cochrane's Risk of Bias tool for randomized studies and the Risk of Bias Assessment tool for non-randomized studies. To estimate the effect size, a meta-analysis of the studies was performed using the Rev Man 5.3 program of the Cochrane Library random-effects models were used in the analyses. Results: Twenty-two studies with a total of 954 participants met the inclusion criteria. Of the 22 studies, 12 were used to estimate the effect size of the non-pharmacologic interventions. The non-pharmacologic interventions used in patients with CIPN were exercise, acupuncture, massage, and foot bath. The acupuncture significantly reduced CIPN symptoms and signs (d=-0.71) and CIPN pain (d=-0.73) (p<.001). Massage and foot bath were also effective in reducing CIPN symptoms (d=-0.68; 95% CI=-1.05, -0.30; p<.001; $I^2=19%$).Exercises were effective in improving muscle strength and endurance(d=-0.55) and quality of life (d=-2.96), but they were not significantly effective in improving CIPN. Conclusion: Although these results provide little evidence of the effectiveness of acupuncture, massage, and foot bath in the treatment of CIPN, they suggest that these interventions can reduce CIPN symptoms in patients with cancer. However, the findings of this study should be interpreted with caution as there is a relative lack of data in this field, and additional well-designed studies are needed. PROSPERO registration: CRD42017076278.

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참고문헌

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피인용 문헌

  1. Research Trend about Complementary and Alternative Therapy in Korea using Text Network Analysis vol.21, pp.2, 2018, https://doi.org/10.7587/kjrehn.2018.61
  2. 항암제 유발 말초신경병증 한의 치험 2례 vol.24, pp.2, 2018, https://doi.org/10.15432/jkto.2019.24.2.023
  3. Effects of Nonpharmacological Interventions in Chemotherapy-Induced Peripheral Neuropathy: An Overview of Systematic Reviews and Meta-Analyses vol.19, pp.None, 2018, https://doi.org/10.1177/1534735420945027
  4. Prescribing for persistent cancer pain: focus on chemotherapy-induced peripheral neuropathy vol.2, pp.4, 2018, https://doi.org/10.12968/jprp.2020.2.4.176
  5. 항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석 vol.25, pp.2, 2020, https://doi.org/10.15432/jkto.2020.25.2.023
  6. The Effects of Foot Reflexology on the Physical Symptoms of Cancer Patients vol.30, pp.1, 2021, https://doi.org/10.15857/ksep.2021.30.1.8