Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells

  • Choi, Seo-Yun (Department of Food Science and Biotechnology, College of Life Science, CHA University) ;
  • Kim, Kui-Jin (Department of Food Science and Biotechnology, College of Life Science, CHA University) ;
  • Song, Ji-Hyeon (Department of Food Science and Biotechnology, College of Life Science, CHA University) ;
  • Lee, Boo-Yong (Department of Food Science and Biotechnology, College of Life Science, CHA University)
  • Received : 2017.01.24
  • Accepted : 2017.02.15
  • Published : 2018.04.15
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Abstract

Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.

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References

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