Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans

  • Kim, Sung Hee (Department of Clinical Nutrition, School of Public Health, Dongduk Women's University) ;
  • Park, Yeong Mi (Department of Foods and Nutrition, College of Natural Sciences, Dongduk Women's University) ;
  • Choi, Bo Youl (Department of Preventive Medicine, College of Medicine, Hanyang University) ;
  • Kim, Mi Kyung (Department of Preventive Medicine, College of Medicine, Hanyang University) ;
  • Roh, Sungwon (Department of Psychiatry, College of Medicine, Hanyang University) ;
  • Kim, Kyunga (Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center) ;
  • Yang, Yoon Jung (Department of Foods and Nutrition, College of Natural Sciences, Dongduk Women's University)
  • Received : 2017.11.02
  • Accepted : 2018.02.06
  • Published : 2018.04.01
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Abstract

BACKGROUND/OBJECTIVES: Korea is quickly becoming an aged society. Dementia is also becoming a vital public health problem in Korea. Cognitive impairment as a pre-stage of dementia shares most risk factors for dementia. The aim of the present study was to determine associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans. SUBJECTS/METHODS: In this cross-sectional study, a total of 230 participants aged 60-79 years from Yangpyeong cohort were included. Cognitive function was assessed by the Korean version of the Mini-Mental State Examination for Dementia Screening. The logistic multivariable regression model was applied to determine the effect of serum vitamins A, C, and E on the risk of cognitive impairment. RESULTS: There was no significant association between the risk of cognitive impairment and serum levels of vitamin A and vitamin C. There was a significant odd ratio when the second tertile group of beta-gamma tocopherol level was compared to the first tertile group [odds ratio (OR) = 0.37, 95% confidence interval (CI) = 0.14-0.98, P for trend = 0.051]. In subgroup analyses, there were significant negative associations between beta-gamma tocopherol level and the risk of cognitive impairment in men (OR = 0.17, 95% CI = 0.03-0.87, P for trend = 0.028), non-drinkers or former drinkers (OR = 0.13, 95% CI = 0.02-0.66, P for trend = 0.025), and non-smokers or former smokers (OR = 0.27, 95% CI = 0.09-0.82, P for trend = 0.017). CONCLUSION: Serum beta-gamma tocopherol levels tended to be inversely associated with the risk of cognitive impairment. Further prospective large-scaled studies are needed to examine this association.

Keywords

References

  1. Statistics Korea. 2016 population and housing census [Internet]. Dajeon: Statistics Korea; 2016 [cited 2018 February 20]. Available from http://kosis.kr/statHtml/statHtml.do?orgId=101&tblId=DT_1IN1603&conn_path=I2
  2. Yanhong O, Chandra M, Venkatesh D. Mild cognitive impairment in adult: a neuropsychological review. Ann Indian Acad Neurol 2013;16:310-8. https://doi.org/10.4103/0972-2327.116907
  3. Ministry for Health, Welfare and Family Affairs; Seoul National University Hospital. Nationwide Study on the Prevalence of Dementia in Korean Elders. Seoul: Ministry for Health, Welfare and Family Affairs; 2008.
  4. Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 1995;62:1448S-1461S.
  5. Jha P, Flather M, Lonn E, Farkouh M, Yusuf S. The antioxidant vitamins and cardiovascular disease. A critical review of epidemiologic and clinical trial data. Ann Intern Med 1995;123:860-72. https://doi.org/10.7326/0003-4819-123-11-199512010-00009
  6. Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-92. https://doi.org/10.1056/NEJMoa011090
  7. Ortega RM, Requejo AM, Andres P, Lopez-Sobaler AM, Quintas ME, Redondo MR, Navia B, Rivas T. Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr 1997;66:803-9. https://doi.org/10.1093/ajcn/66.4.803
  8. Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 1999;282:1233-9. https://doi.org/10.1001/jama.282.13.1233
  9. Reiter RJ. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995;9:526-33. https://doi.org/10.1096/fasebj.9.7.7737461
  10. Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol 2006;65:631-41. https://doi.org/10.1097/01.jnen.0000228136.58062.bf
  11. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84. https://doi.org/10.1016/j.biocel.2006.07.001
  12. Hu P, Bretsky P, Crimmins EM, Guralnik JM, Reuben DB, Seeman TE. Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 2006;61:616-20. https://doi.org/10.1093/gerona/61.6.616
  13. Kang JH, Cook N, Manson J, Buring JE, Albert CM, Grodstein F. A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am J Clin Nutr 2008;88:1602-10. https://doi.org/10.3945/ajcn.2008.26404
  14. Sato R, Helzlsouer KJ, Comstock GW, Hoffman SC, Norkus EP. A cross-sectional study of vitamin C and cognitive function in older adults: the differential effects of gender. J Nutr Health Aging 2006;10:37-44.
  15. Lindeman RD, Romero LJ, Koehler KM, Liang HC, LaRue A, Baumgartner RN, Garry PJ. Serum vitamin B12, C and folate concentrations in the New Mexico elder health survey: correlations with cognitive and affective functions. J Am Coll Nutr 2000;19:68-76. https://doi.org/10.1080/07315724.2000.10718916
  16. Mangialasche F, Solomon A, Kareholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Exp Gerontol 2013;48:1428-35. https://doi.org/10.1016/j.exger.2013.09.006
  17. World Health Organization. Indicators for Assessing Vitamin A Deficiency and Their Application in Monitoring and Evaluating Intervention Programmes. Geneva: World Health Organization; 1996.
  18. Richter A, Kuhlmann MK, Seibert E, Kotanko P, Levin NW, Handelman GJ. Vitamin C deficiency and secondary hyperparathyroidism in chronic haemodialysis patients. Nephrol Dial Transplant 2008;23:2058-63. https://doi.org/10.1093/ndt/gfn084
  19. Mahan LK, Escott-Stump S, Raymond JL, Krause MV. Krause's Food & the Nutrition Care Process. 13th ed. St. Louis (MO): Elsevier/Saunders; 2012.
  20. Han JW, Kim TH, Jhoo JH, Park JH, Kim JL, Ryu SH, Moon SW, Choo IH, Lee DW, Yoon JC, Do YJ, Lee SB, Kim MD, Kim KW. A normative study of the Mini-Mental State Examination for Dementia Screening (MMSE-DS) and its short form (SMMSE-DS) in the Korean elderly. J Korean Geriatr Psychiatry 2010;14:27-37.
  21. Sodhi RK, Singh N. All-trans retinoic acid rescues memory deficits and neuropathological changes in mouse model of streptozotocininduced dementia of Alzheimer's type. Prog Neuropsychopharmacol Biol Psychiatry 2013;40:38-46. https://doi.org/10.1016/j.pnpbp.2012.09.012
  22. Fragoso YD, Stoney PN, McCaffery PJ. The evidence for a beneficial role of vitamin A in multiple sclerosis. CNS Drugs 2014;28:291-9. https://doi.org/10.1007/s40263-014-0148-4
  23. Ono K, Yamada M. Vitamin A and Alzheimer's disease. Geriatr Gerontol Int 2012;12:180-8. https://doi.org/10.1111/j.1447-0594.2011.00786.x
  24. Jeandel C, Nicolas MB, Dubois F, Nabet-Belleville F, Penin F, Cuny G. Lipid peroxidation and free radical scavengers in Alzheimer's disease. Gerontology 1989;35:275-82. https://doi.org/10.1159/000213037
  25. Perrig WJ, Perrig P, Stahelin HB. The relation between antioxidants and memory performance in the old and very old. J Am Geriatr Soc 1997;45:718-24. https://doi.org/10.1111/j.1532-5415.1997.tb01476.x
  26. Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Neurology 2001;56:1188-94.
  27. Peters R, Poulter R, Warner J, Beckett N, Burch L, Bulpitt C. Smoking, dementia and cognitive decline in the elderly, a systematic review. BMC Geriatr 2008;8:36. https://doi.org/10.1186/1471-2318-8-36
  28. Anstey KJ, von Sanden C, Salim A, O'Kearney R. Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies. Am J Epidemiol 2007;166:367-78. https://doi.org/10.1093/aje/kwm116
  29. Saunders PA, Copeland JR, Dewey ME, Davidson IA, McWilliam C, Sharma V, Sullivan C. Heavy drinking as a risk factor for depression and dementia in elderly men. Findings from the Liverpool longitudinal community study. Br J Psychiatry 1991;159:213-6. https://doi.org/10.1192/bjp.159.2.213
  30. Statistics Korea. 2010 population and housing census [Internet]. Daejeon: Statistics Korea; 2010 [cited 2017 August 16]. Available from: http://kosis.kr/statHtml/statHtml.do?orgId=101&tblId=DT_1PG1501&conn_path=I2.

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