Korean Journal of Microbiology (미생물학회지)

The Microbiological Society of Korea (한국미생물학회)
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Molecular epidemiological study of norovirus gastroenteritis outbreaks in Gyeonggi-Do from 2014 to 2015

2014-2015년 경기지역 노로바이러스성 식중독의 분자역학적 특성분석

  • Nam, Soo-Jung (Team of virus, Gyeonggi Institute of Health and Environment) ;
  • Park, Po-Hyun (Team of virus, Gyeonggi Institute of Health and Environment) ;
  • Bang, Sun-Jae (Team of virus, Gyeonggi Institute of Health and Environment) ;
  • Huh, Jeong-Weon (Team of virus, Gyeonggi Institute of Health and Environment) ;
  • Yun, Hee-Jeong (Team of virus, Gyeonggi Institute of Health and Environment) ;
  • Park, Kwang-Hee (Team of virus, Gyeonggi Institute of Health and Environment) ;
  • Yoon, Mi-Hye (Team of virus, Gyeonggi Institute of Health and Environment)
  • 남수정 (경기도보건환경연구원 바이러스팀) ;
  • 박포현 (경기도보건환경연구원 바이러스팀) ;
  • 방선재 (경기도보건환경연구원 바이러스팀) ;
  • 허정원 (경기도보건환경연구원 바이러스팀) ;
  • 윤희정 (경기도보건환경연구원 바이러스팀) ;
  • 박광희 (경기도보건환경연구원 바이러스팀) ;
  • 윤미혜 (경기도보건환경연구원 바이러스팀)
  • Received : 2017.05.30
  • Accepted : 2017.09.25
  • Published : 2018.03.31
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Abstract

Norovirus infection is a leading cause of nonbacterial gastroenteritis outbreaks. New variants of GII.4 have emerged approximately every 2~3 years and have caused norovirus gastroenteritis pandemics globally. In this study, analysis and molecular genetic characteristics of the norovirus gastroenteritis outbreaks 2,917 samples in Gyeonggi-Do from 2014 to 2015. As a result, 247 samples out of 2,917 samples are positive for norovirus. Norovirus molecular genetic characteristics of the GI 8 types (GI-1, 2, 3, 4, 5, 6, 12, 14), GII 10 types (GII - 2, 3, 4, 5, 6, 11, 12, 14, 16, 17). Genome sequences of isolated noroviruses were similar to those of new GII.17 Kawasaki 2014 variants with 96.6 identity, suggesting that these viruses were imported from overseas. 44% of virus incidence was originated from school meal service. Therefore, a continuous monitoring and school sanitation should be required for preventing a massive virus outbreak.

노로바이러스는 식중독을 유발하는 주요 병원체이며, 최근 GII.4 변이주의 출현으로 전세계적으로 2~3년 주기로 유행하고 있다. 본 연구에서는 2014년부터 2015년까지 2년간 경기도 내 집단식중독 검체 2,917건을 대상으로 노로바이러스성 식중독 발생양상을 파악하고 분자유전학적 특성을 분석하였다. 검사결과 노로바이러스가 247건으로 가장 많았으며, 분자유전학적 특성은 GI 형에서 8종(GI-1, 2, 3, 4, 5, 6, 12, 14), GII형에서 10종(GII-2, 3, 4, 5, 6, 11, 12, 14, 16, 17)으로 다양하게 분포하고 있는 것으로 나타났다. 2015년 초 집단발생한 노로바이러스 35건에 대한 유전계통학적 분석결과 GII-17 kawasaki 2014형으로 알려진 분리주와 96.6% 이상 일치하여 새로운 변이주에 의한 유행이었음을 확인하였으며, 학교 등 급식에 의한 비율이 44%로 단체급식 위생에 주의하는 한편 발생 원인을 파악하여, 대규모 식중독 유행에 대비하여야 할 것으로 판단된다.

Keywords

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