Mass Spectrometry Letters

Korean Society for Mass Spectrometry (한국질량분석학회)
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Development of a Nutritional Supplement Certified Reference Material for Elemental Analysis

  • Lee, Jong Wha (Center for Analytical Chemistry, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science (KRISS)) ;
  • Heo, Sung Woo (Center for Analytical Chemistry, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science (KRISS)) ;
  • Kim, Hwijin (Center for Analytical Chemistry, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science (KRISS)) ;
  • Lim, Youngran (Center for Analytical Chemistry, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science (KRISS)) ;
  • Lee, Kyoung-Seok (Center for Analytical Chemistry, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science (KRISS)) ;
  • Yim, Yong-Hyeon (Center for Analytical Chemistry, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science (KRISS))
  • Received : 2018.12.05
  • Accepted : 2018.12.18
  • Published : 2018.12.30
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Abstract

A certified reference material (CRM) for the analysis of inorganic nutrients in nutritional supplements has been developed. Accurate mass fractions of chromium (Cr), iron (Fe), copper (Cu), and zinc (Zn) were determined by isotope dilution inductively coupled plasma mass spectrometry (ID ICP/MS). The measurement results were used to assign certified values for the CRM, which were metrologically traceable to the definitions of the measurement units in the International System of Units (SI). Production of a candidate reference material (RM) and the certification processes are summarized. Each nutrient in the CRM showed good homogeneity, which was estimated using relative standard deviations of the measurement results of twelve bottles in a batch. This CRM is expected to be an important reference to improve reliability and comparability of nutrient analyses in nutritional supplements and related samples in analytical laboratories.

Keywords

E1MPSV_2018_v9n4_105_f0001.png 이미지

Figure 1. Measured mass fractions of Cr, Fe, Cu, and Zn (from top to bottom) for samples from individual bottles. The error bars denote the uncertainties from systematic effects and repeatability of the measurement results for each individual sample.

Table 1. Comparison between certified values and associated expanded uncertainties (mg/kg) for the nutritional supplements and a related CRM. Relative associated expanded uncertainties and coverage factors at the 95% level of confidence are shown in parentheses

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Table 2. Major sources of measurement uncertainties for the certified value of each element.

E1MPSV_2018_v9n4_105_t0002.png 이미지

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