Journal of Powder Materials (한국분말재료학회지)

The Korean Powder Metallurgy & Materials Institute (한국분말재료학회 (*구 분말야금학회))
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Nanodiamonds Conjugated with Nonsteroidal Anti-inflammatory Drugs for Transdermal Delivery

  • Rhee, Changkyu (Nuclear Materials Research Division, Korea Atomic Energy Research Institute (KAERI)) ;
  • Puzyr, Alexey P. (Institute of Biophysics, Siberian Branch of Russian Academy of Science, Krasnoyarsk Science Center SB RAS) ;
  • Burov, Andrey E. (Institute of Biophysics, Siberian Branch of Russian Academy of Science, Krasnoyarsk Science Center SB RAS) ;
  • Burova, Olga G. (School of Architecture and Design, Siberian Federal University) ;
  • Kim, Whungwhoe (Nuclear Materials Research Division, Korea Atomic Energy Research Institute (KAERI)) ;
  • Bondar, Vladimir S. (Institute of Biophysics, Siberian Branch of Russian Academy of Science, Krasnoyarsk Science Center SB RAS)
  • Received : 2018.11.06
  • Accepted : 2018.12.24
  • Published : 2018.12.28
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Abstract

Most commercially available detonation nanodiamonds (DNDs) require further processing to qualify for use in biomedical applications, as they often contain many impurities and exhibit poor dispersibility in aqueous media. In this work, DNDs are modified to improve purity and impart a high colloidal stability to the particles. The dispersive and adsorption properties of modified DNDs are evaluated in terms of the suitability of DNDs as carriers for non-steroidal anti-inflammatory drugs (NSAIDs) in transdermal delivery. The study of adsorption on strongly positively and strongly negatively charged DNDs showed their high loading capacity for NSAIDs, and a pronounced relationship between the drugs and the particles' charges. Experiments on long-term desorption carried out with DND/NSAID complexes indicate that the nanoparticles exert a sustained effect on the drug release process.

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References

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