Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Study on animal Ocular irritation test of ozonated olive oil

오존화 올리브오일의 동물 눈 안점막 자극시험 연구

  • Kim, Duck-Sool (Dept. of Biomedical Engineering, TongMyong University)
  • 김덕술 (동명대학교 의용공학과)
  • Received : 2018.12.04
  • Accepted : 2018.12.21
  • Published : 2018.12.31
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Abstract

This study suggests that ozonated olive oil can kill a wide variety of microorganisms while being less toxic but in the case of administration or abdominal administration, the human body is harmless. In Korea, there is no animal stability test yet. In this study, ozonated olive oil was used to test the stability of the animal through the eye. Specific experiments were performed to evaluate animal Ocular irritation safe test of ozonized oil (high concentration) in rabbits. and Observation of the treatment point on the test substance, ozonated olive oil showed no Ocular irritation in both the non-washing group and the washing group.

본 연구는 오존화 올리브오일이 독성이 적으면서 다양한 종류의 미생물을 치사시킬 수 있으나 경우투여나 복강투여에도 인체에 해가 없는 것으로 알려져 있다. 그리고 국내에서는 아직 동물에 대한 안정성 실험이 없었다. 그래서 본 연구에서는 오존화 올리브오일을 사용하여 동물의 안구를 통한 안정성 실험을 하였다. 구체적인 연구에서는 rabbit에서 오존화오일(고농도)의 동물 눈 안점막 자극을 평가하기 위해 실시하였고, 시험물질 처치부위를 관찰한 결과, 비세척군 및 세척군 모두에서 안점막 자극이 관찰되지 않았다.

Keywords

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Fig. 1. Eye photographs of non-washing group on day 1 after application of test substance

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Fig. 2. Eye photographs of non-washing group on day 7 after application of test substance

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Fig. 3. Eye photographs of washing group on day 1 after application of test substance

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Fig. 4. Eye photographs of washing group on day 7 after application of test substance

Table 1. Evaluation of eye irritation

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