Applied Microscopy

Korean Society of Microscopy (한국현미경학회)
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Structural Studies of Respirasome by Cryo-Electron Microscopy

  • Jeon, Tae Jin (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Kim, Ho Min (Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Ryu, Seong Eon (Department of Bioengineering, College of Engineering, Hanyang University)
  • Received : 2018.10.25
  • Accepted : 2018.11.22
  • Published : 2018.12.30
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Abstract

The respiratory chain complex forms a supercomplex (SC) in the inner mitochondrial membrane. This complex facilitates the process of electron transfer to produce the proton gradient used to synthesize ATP. Understanding the precise structure of the SC is considered an important challenge. However, it has not yet been reported. The development of a Cryo-electron microscopy (EM) technique provides an effective way to obtain high-resolution micrographs to determine the high-resolution three-dimensional structure of biomolecules. In this brief review, the currently reported Cryo-EM structures of the mammalian respirasome have been described in order to establish a direction for further research in the respiratory system.

Keywords

References

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