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Screening Herbal Decoction of the Vascular Relaxation in Korean Medicine

한의학(韓醫學)에서 사용되는 한약제제(韓藥製劑)의 혈관이완 효능검색

  • Kim, Hye-Yoom (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Seo, Chang-Seob (K-herb Research Center, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (K-herb Research Center, Korea Institute of Oriental Medicine) ;
  • Hong, Mi-Hyeon (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Yoon, Jung-Joo (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Ahn, You-Mee (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Eun, So-Young (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun-Jung (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
  • 김혜윰 (원광대학교 한의과대학 생리학교실) ;
  • 서창섭 (한국한의학연구원 K-herb연구단) ;
  • 신현규 (한국한의학연구원 K-herb연구단) ;
  • 홍미현 (원광대학교 한의과대학 생리학교실) ;
  • 윤정주 (원광대학교 한의과대학 생리학교실) ;
  • 안유미 (원광대학교 한의과대학 생리학교실) ;
  • 은소영 (원광대학교 한의과대학 생리학교실) ;
  • 이윤정 (원광대학교 한의과대학 생리학교실) ;
  • 이호섭 (원광대학교 한의과대학 생리학교실) ;
  • 강대길 (원광대학교 한의과대학 생리학교실)
  • Received : 2018.01.24
  • Accepted : 2018.02.14
  • Published : 2018.02.23

Abstract

Objectives: This study was designed to investigate the basis for developing the herbal decoction that may help promote healthy blood vessels in accordance with the basic principles of Korean medicinal materials. Methods: In this study, we investigated the vascular relaxation effects of fifty herbal decoctions on vascular response in isolated thoracic aorta of phenylephrine-preconracted rats. Results: The results of identify the vascular relaxation effect of fifty herbal decoctions provided by Korea Institute of Korean Medicine, twenty-one herbal decoctions showed vascular relaxation effects. Among them, four herbal decoctions, Mahwang-tang (麻黃湯), Samchulgeonbi-tang (參朮健脾湯), Cheonwangbosim-dan (天王補心丹), and Socheonglyong-tang (小靑龍湯), with showed significantly concentration-dependent vasodilation was examined. Vascular relaxation level are $84.02{\pm}4.70$, $79.39{\pm}13.9$, $51.26{\pm}12.56$, and $54.73{\pm}15.8%$, respectively (P<0.05, 0.01, and 0.001). Conclusions: Thus these results provide a basic data for the treatment of the impairment of vascular function and blood pressure in traditional Oriental medicine.

Keywords

References

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