대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)

  • 제50권4호
  • /
  • Pages.484-491
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  • 2018
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  • 1738-3544(pISSN)
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  • 2288-1662(eISSN)
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)
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Relationships of the Vitamin D and Platelet Indices in Sjögren's Syndrome

  • Gunay, Nahide Ekici (Department of Clinical Biochemistry, University of Health Science, Kayseri City Training and Research Hospital) ;
  • Bugday, Irfan (Department of General Medicine, University of Health Science, Yesilhisar State Hospital) ;
  • Akalin, Tayfun (Department of General Medicine, Division of Rheumatology, University of Health Science, Kayseri City Training and Research Hospital)
  • 투고 : 2018.09.29
  • 심사 : 2018.11.01
  • 발행 : 2018.12.31
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초록

Primer $Sj{\ddot{o}}gren's$ Syndrome (pSS) is an autoimmune/inflammatory illness. The platelet indices (PIs) indicate the inflammatory response and activity/severity of many diseases. A vitamin D deficiency is accompanied by the increased tendency of autoimmune diseases. This study investigated whether the vitamin D levels are related to the altered platelet indices in pSS. A total of 261 individuals were included in this analytical cross-sectional study. The laboratory data of pSS patients were evaluated and the relationship between the PIs and vitamin D status was examined. According to these findings, in patients with pSS, the vitamin D levels were lower than the healthy control group (P<0.05). The vitamin D levels were negatively associated with PDW (P=0.012), but positively correlated with PCT (P<0.001). The cut-off point was obtained with receiver operating characteristics (ROC) curves for PDW: 12.53 (AUC 0.921, sensitivity 90%, specificity 85%), for PCT; 0.29 (AUC 0.660, sensitivity 68%, specificity 55%). In multivariate linear regression analysis, the most significant parameters for the effects of PDW are the following: vitamin D (${\beta}=-0.373$; t=-2.626; sig.=0.013) and plateletcrit (${\beta}=-0.308$; t=-2.13; sig.=0.040). A vitamin D deficiency may be accompanied by changes in PIs in pSS. A higher PDW and lower PCT supports the underlying inflammation, which may be vitamin D related useful parameters to consider in approaching to pSS.

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참고문헌

  1. Moutsopoulos HM. Sjogren's syndrome: autoimmune epithelitis. Clin Immunol Immunopathol. 1994;72:162-165. https://doi.org/10.1006/clin.1994.1123
  2. Birlik M, Akar S, Gurler O, Sari I, Birlik B, Sarioglu S, et al. Prevalence of primary Sjogren's syndrome in Turkey: a population-based epidemiological study. Int J Clin Pract. 2009; 63:954-961. https://doi.org/10.1111/j.1742-1241.2008.01749.x.
  3. Kabasakal Y, Kitapcioglu G, Turk T, Oder G, Durusoy R, Mete N, et al. The prevalence of Sjogren's syndrome in adult women. Scand J Rheumatol. 2006;35:379-383. https://doi.org/10.1080/03009740600759704
  4. Duzgun N, Sahin M, Genc Y, Tutkak H. Antinucleosome antibodies and systemic lupus erythematosus. Ann N Y Acad Sci. 2007;1109:421-428. https://doi.org/10.1196/annals.1398.048
  5. Akkoc N, Akar S. Epidemiology of rheumatoid arthritis in Turkey. Clin Rheumatol. 2006;25:560-561. https://doi.org/10.1007/s10067-005-0092-2
  6. Altieri B, Muscogiuri G, Barrea L, Mathieu C, Vallone CV, Mascitelli L, at al. Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. Rev Endocr Metab Disord. 2017;18:335-346. https://doi.org/10.1007/s11154-016-9405-9.
  7. Cantorna MT. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med. 2000;223:230-233. https://doi.org/10.1046/j.1525-1373.2000.22333.x
  8. Cutolo M. Vitamin D or hormone D deficiency in autoimmune rheumatic diseases, including undifferentiated connective tissue disease. Arthritis Res Ther. 2008;10:123. https://doi.org/10.1186/ar2552.
  9. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157-161. https://doi.org/10.1097/00001721-199603000-00011
  10. Barry RJ, Sutcliffe N, Isenberg DA, Price E, Goldblatt F, Adler M, et al. The Sjogren's syndrome damage index-a damage index for use in clinical trials and observational studies in primary Sjogren's syndrome. Rheumatology (Oxford). 2008;47:1193-1198. https://doi.org/10.1093/rheumatology/ken164.
  11. Bowman SJ, Sutcliffe N, Isenberg DA, Goldblatt F, Adler M, Price E, et al. Sjogren's systemic clinical activity index (SCAI)-a systemic disease activity measure for use in clinical trials in primary Sjogren's syndrome. Rheumatology (Oxford). 2007;46: 1845-1851. https://doi.org/10.1093/rheumatology/kem280.
  12. Vitali C, Palombi G, Baldini C, Benucci M, Bombardieri S, Covelli M, et al. Sjogren's syndrome Disease Damage Index and disease activity index: scoring systems for the assessment of disease damage and disease activity in Sjogren's syndrome, derived from an analysis of a cohort of Italian patients. Arthritis Rheum. 2007;56:2223-2231. https://doi.org/10.1002/art.22658.
  13. Giovanetti TV, do Nascimento AJ, de paula JP. Platelet indices: laboratory and clinical applications. Rev Bras Hematol Hemoter. 2011;33:164-165. https://doi.org/10.5581/1516-8484.20110040.
  14. Harrison P, Ault KA, Chapman S, Charie L, Davis B, Fujimoto K, et al. An interlaboratory study of a candidate reference method for platelet counting. Am J Clin Pathol. 2001;115:448-459. https://doi.org/10.1309/91PR-E4G6-XBAF-N8DY.
  15. Jenkinson C, Taylor AE, Hassan-Smith ZK, Adams JS, Stewart PM, Hewison M, et al. High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2016; 1014:56-63. https://doi.org/10.1016/j.jchromb.2016.01.049.
  16. Hardeman MR, Levitus M, Pelliccia A, Bouman AA. Test 1 analyser for determination of ESR. 1. Practical evaluation and comparison with the Westergren technique. Scand J Clin Lab Invest. 2010;70:21-25. https://doi.org/10.3109/00365510903365952.
  17. Drieghe SA, Alsaadi H, Tugirimana PL, Delanghe JR. A new high-sensitive nephelometric method for assaying serum C-reactive protein based on phosphocholine interaction. Clin Chem Lab Med. 2014;52:861-867. https://doi.org/10.1515/cclm-2013-0669.
  18. Eissfeller P, Sticherling M, Scholz D, Hennig K, Luttich T, Motz M, et al. Comparison of different test systems for simultaneous autoantibody detection in connective tissue diseases. Ann N Y Acad Sci. 2005;1050:327-339. https://doi.org/10.1196/annals.1313.035.
  19. Szodoray P, Horvath IF, Papp G, Barath S, Gyimesi E, Csathy L, et al. The immunoregulatory role of vitamins A, D and E inpatients with primary Sjogren's syndrome. Rheumatol (Oxford). 2010;49:211-217. https://doi.org/10.1093/rheumatology/zkep374.
  20. Agmon-Levin N1, Kivity S, Tzioufas AG, Lopez Hoyos M, Rozman B, Efes I, et al. Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sjogren's syndrome. J Autoimmun. 2012;39:234-239. https://doi.org/10.1016/j.jaut.2012.05.018.
  21. Erten S, Sahin A, Altunoglu A, Gemcioglu E, Koca C. Comparison of plasma vitamin D levels in patients with Sjogren's syndrome and healthy subjects. Int J Rheum Dis. 2015;18:70-75. https://doi.org/10.1111/1756-185X.12298.
  22. Margetic S. Inflammation and homeostasis. Biochem Med (Zagreb). 2012;22:49-62.
  23. Farias MG, Schunck EG, Dal Bo S, de Castro SM. Definition of reference ranges for the platelet distribution width (PDW): a local need. Clin Chem Lab Med. 2010;48:255-257. https://doi.org/10.1515/CCLM.2010.035.
  24. Kowara M, Grodecki K, Huczek Z, Puchta D, Paczwa K, Rymuza B, et al. Platelet distribution width predicts left ventricular dysfunction in patients with acute coronary syndromes treated with percutaneous coronary intervention. Kardiol Pol. 2017;75:42-47. https://doi.org/10.5603/KP.a2016.0137.
  25. Vagdatli E, Gournari E, Lazaridou E, Katsiborilia E, Tsikopoulou F, Labrianou I. Platelet distribution width; a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.
  26. Isik M, Sahin H, Huseyin E. New platelet indices as inflammatory parameters for patients with rheumatoid arthritis. Eur J Rheumatol. 2014;1:144-146. https://doi.org/10.5152/eurjrheumatol.2014.140023.
  27. Fan Z, Pan J, Zhang Y, Wang Z, Zhu M, Yang B. Mean platelet volume and platelet distribution width as markers in the diagnosis of acute gangrenous appendicitis. Dis Markers. 2015;2015:542013. https://doi.org/10.1155/2015/542013.
  28. Budak YU, Polat M, Huysal K. The use of platelet indices, plateletecrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochem Med (Zagreb). 2016;26:178-193. https://doi.org/10.11613/BM.2016.020.
  29. Yamauchi N, Muramatsu H, Inomata H, Numata T, Nozawa E, Nishino M, et al. Cyclic thrombocytopenia complicated with Sjogren syndrome and the mechanism of periodic platelet count fluctuation. Rinsho Ketsueki. 2008;49:658-663.
  30. Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, et al. New gene functions in megakaryopoiesis and platelet formation. Nature. 2011;480:201-208. https://doi.org/10.1038/nature10659.
  31. Panova-Noeva M, Schulz A, Hermanns MI, Grossmann V, Pefani E, Spronk HM, et al. Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg health study. Blood. 2016;127:251-259. https://doi.org/10.1182/blood-2015-07-660308.

피인용 문헌

  1. A Fusion Study on the Relationship between Lifestyle and Vitamin D Deficiency in Korean Adults vol.10, pp.12, 2018, https://doi.org/10.15207/jkcs.2019.10.12.159