DOI QR코드

DOI QR Code

A giant trichoblastic carcinoma

  • Lee, Joon Seok (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University) ;
  • Kwon, Joon Hyun (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University) ;
  • Jung, Gyu Sik (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University) ;
  • Lee, Jeong Woo (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University) ;
  • Yang, Jung Dug (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University) ;
  • Chung, Ho Yun (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University) ;
  • Cho, Byung Chae (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University) ;
  • Choi, Kang Young (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University)
  • Received : 2018.09.07
  • Accepted : 2018.10.30
  • Published : 2018.12.20

Abstract

Trichoblastic carcinoma usually occurs as a malignant transformation of the trichoblastoma, but is very rare. A 25-year-old man was admitted with trichoblastoma in the nuchal area with frequent recurrences since birth. The preoperative neck magnetic resonance image revealed lobulated soft tissue lesions involving superficial fascia and infiltrating into both proximal trapezius muscles. In our department, wide excision and reconstruction with a free anterolateral thigh flap were performed. Histological examination revealed skin adnexal carcinoma, originating from the hair follicles, consistent with trichoblastic carcinoma. There was no palpable mass 5 years postoperatively, and there was no recurrence on follow-up positron emission tomography-computed tomography. Trichoblastic carcinomas are rare and difficult to diagnose, but histopathological findings include atypical basaloid keratinocytes with crowded, hyperchromatic nuclei, and increased mitotic activity. The presence of hypercellular stroma is a criterion for distinguishing trichoblastic carcinoma from basal cell carcinoma. A rare giant trichoblastic carcinoma was reported, which was the biggest one in the literature.

Keywords

References

  1. Headington JT, French AJ. Primary neoplasms of the hair follicle: histogenesis and classification. Arch Dermatol 1962;86: 430-41. https://doi.org/10.1001/archderm.1962.01590100044012
  2. Laffay L, Depaepe L, d'Hombres A, Balme B, Thomas L, De Bari B. Histological features and treatment approach of trichoblastic carcinomas: from a case report to a review of the literature. Tumori 2012;98:46e-49e. https://doi.org/10.1177/030089161209800222
  3. Kazakov DV, Vittay G, Michal M, Calonje E. High-grade trichoblastic carcinosarcoma. Am J Dermatopathol 2008;30: 62-4. https://doi.org/10.1097/DAD.0b013e31815c6c7f
  4. Kazakov DV, Kempf W, Michal M. Low-grade trichoblastic carcinosarcoma of the skin. Am J Dermatopathol 2004;26:304-9. https://doi.org/10.1097/00000372-200408000-00007
  5. Lee KH, Kim JE, Cho BK, Kim YC, Park CJ. Malignant transformation of multiple familial trichoepithelioma: case report and literature review. Acta Derm Venereol 2008;88:43-6. https://doi.org/10.2340/00015555-0322