그림 1. 자료선택의 흐름도. 국민건강영양조사 6기
그림 2. 당뇨병 유병기간에 따른 심혈관 위험 인자들의 빈도 특성(%)
표 1. 당뇨병 유병기간에 따른 심혈관 위험 인자 특성
표 2. 당뇨병 유병기간에 따른 심혈관 위험인자들의 위험도
표 3. 당뇨병 유병기간에 따른 합병증의 빈도특성
References
- J. A. Beckman, M. A. Creager, and P. Libby, "Diabetes and atherosclerosis: epidemiology, pathophysiology, and management," JAMA, Vol.287, No.19, pp.2570-2581, 2002. https://doi.org/10.1001/jama.287.19.2570
- J. Y. Jeon, S. H. Ko, H. S. Kwon, N. H. Kim, J. H. Kim, C. S. Kim, K. H. Song, J. C. Won, S. Lim, S. H. Choi, M. J. Jang, Y. Kim, K. Oh, D. J. Kim, B. Y. Cha, and A. Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes, "Prevalence of Diabetes and Prediabetes according to Fasting Plasma Glucose and HbA1c," Diabetes Metab J, Vol.37, No.5, pp.349-357, 2013. https://doi.org/10.4093/dmj.2013.37.5.349
- C. A. Reasner, "Reducing cardiovascular complications of type 2 diabetes by targeting multiple risk factors," J Cardiovasc Pharmacol, Vol.52, No.2, pp.136-144, 2008. https://doi.org/10.1097/FJC.0b013e31817ffe5a
- S. Rao Kondapally Seshasai, S. Kaptoge, A. Thompson, E. Di Angelantonio, P. Gao, N. Sarwar, P. H. Whincup, K. J. Mukamal, R. F. Gillum, I. Holme, I. Njolstad, A. Fletcher, P. Nilsson, S. Lewington, R. Collins, V. Gudnason, S. G. Thompson, N. Sattar, E. Selvin, F. B. Hu, J. Danesh, and C. Emerging Risk Factors, "Diabetes mellitus, fasting glucose, and risk of cause-specific death," N Engl J Med, Vol.364, No.9, pp.829-841, 2011. https://doi.org/10.1056/NEJMoa1008862
- C. Centers for Disease and Prevention, "Prevalence of self-reported cardiovascular disease among persons aged > or =35 years with diabetes-United States, 1997-2005," MMWR Morb Mortal Wkly Rep, Vol.56, No.43, pp.1129-1132, 2007.
- Korea National Health and Nutrition Examination Survey, https://knhanes.cdc.go.kr/knhanes/sub03/sub03_02_02.do
- A. American Diabetes, "Standards of medical care in diabetes-2015 abridged for primary care providers," Clin Diabetes, Vol.33, No.2, pp.97-111, 2015. https://doi.org/10.2337/diaclin.33.2.97
- P. A. James, S. Oparil, B. L. Carter, W. C. Cushman, C. Dennison-Himmelfarb, J. Handler, D. T. Lackland, M. L. LeFevre, T. D. MacKenzie, O. Ogedegbe, S. C. Smith Jr., L. P. Svetkey, S. J. Taler, R. R. Townsend, J. T. Wright Jr., A. S. Narva, and E. Ortiz, "2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)," JAMA, Vol.311, No.5, pp.507-520, 2014. https://doi.org/10.1001/jama.2013.284427
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, "Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)," JAMA, Vol.285, No.19, pp.2486-2497, 2001. https://doi.org/10.1001/jama.285.19.2486
- Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults, "Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary," Am J Clin Nutr, Vol.68, No.4, pp.899-917, 1998. https://doi.org/10.1093/ajcn/68.4.899
- E. J. Lamb, C. R. Tomson, P. J. Roderick, and B. Clinical Sciences Reviews Committee of the Association for Clinical, "Estimating kidney function in adults using formulae," Ann Clin Biochem, Vol.42, No.Pt 5, pp.321-345, 2005. https://doi.org/10.1258/0004563054889936
- Korean Statistical Information Service, http://www.kosis.kr/statHtml/statHtml.do?orgId=117&tblId=DT_11702_N102
- R. Lajara, R. Aguilar, U. Hehnke, H. J. Woerle, and M. von Eynatten, "Efficacy and safety of linagliptin in subjects with long-standing type 2 diabetes mellitus (>10 years): evidence from pooled data of randomized, double-blind, placebo-controlled, phase III trials," Clin Ther, Vol.36, No.11, pp.1595-1605, 2014. https://doi.org/10.1016/j.clinthera.2014.07.020
- E. Szoke, M. Z. Shrayyef, S. Messing, H. J. Woerle, T. W. van Haeften, C. Meyer, A. Mitrakou, W. Pimenta, and J. E. Gerich, "Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance," Diabetes Care, Vol.31, No.3, pp.539-543, 2008. https://doi.org/10.2337/dc07-1443
- D. J. Margolis, O. Hoffstad, and B. L. Strom, "Association between serious ischemic cardiac outcomes and medications used to treat diabetes," Pharmacoepidemiol Drug Saf, Vol.17, No.8, pp.753-759, 2008. https://doi.org/10.1002/pds.1630
- J. M. Gamble, S. H. Simpson, D. T. Eurich, S. R. Majumdar, and J. A. Johnson, "Insulin use and increased risk of mortality in type 2 diabetes: a cohort study," Diabetes Obes Metab, Vol.12, No.1, pp.47-53, 2010. https://doi.org/10.1111/j.1463-1326.2009.01125.x
- V. Patney, A. Whaley-Connell, and G. Bakris, "Hypertension Management in Diabetic Kidney Disease," Diabetes Spectr, Vol.28, No.3, pp.175-180, 2015. https://doi.org/10.2337/diaspect.28.3.175
- A. J. Hahr and M. E. Molitch, "Management of diabetes mellitus in patients with chronic kidney disease," Clin Diabetes Endocrinol, Vol.1, p.2, 2015. https://doi.org/10.1186/s40842-015-0001-9
- D. Orozco-Beltran, V. F. Gil-Guillen, F. Quirce, J. Navarro-Perez, M. Pineda, A. Gomez-dela- Camara, S. Pita, J. Diez-Espino, J. Mateos, J. Merino, M. Serrano-Rios, and I. Collaborative Diabetes Study, "Control of diabetes and cardiovascular risk factors in patients with type 2 diabetes in primary care. The gap between guidelines and reality in Spain," Int J Clin Pract, Vol.61, No.6, pp.909-915, 2007. https://doi.org/10.1111/j.1742-1241.2007.01367.x
- F. P. Schena and L. Gesualdo, "Pathogenetic mechanisms of diabetic nephropathy," Journal of the American Society of Nephrology, Vol.16, No.3, Suppl.1, pp.S30-S33, 2005. https://doi.org/10.1681/ASN.2004110970
- M. J. Fowler, "Microvascular and macrovascular complications of diabetes," Clinical diabetes, Vol.26, No.2, pp.77-82, 2008. https://doi.org/10.2337/diaclin.26.2.77
- A. I. Adler, R. J. Stevens, S. E. Manley, R. W. Bilous, C. A. Cull, R. R. Holman, and G. Ukpds, "Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)," Kidney Int, Vol.63, No.1, pp.225-232, 2003. https://doi.org/10.1046/j.1523-1755.2003.00712.x
- F. A. El-Atat, S. N. Stas, S. I. McFarlane, and J. R. Sowers, "The relationship between hyperinsulinemia, hypertension and progressive renal disease," Journal of the American Society of Nephrology, Vol.15, No.11, pp.2816-2827, 2004. https://doi.org/10.1097/01.ASN.0000133698.80390.37
- P. J. Boyle, "Diabetes mellitus and macrovascular disease: mechanisms and mediators," Am J Med, Vol.120, No.9, Suppl.2, pp.S12-17, 2007. https://doi.org/10.1016/j.amjmed.2007.07.003
- M. Sakamoto, "Type 2 Diabetes and Glycemic Variability: Various Parameters in Clinical Practice," J Clin Med Res, Vol.10, No.10, pp.737-742, 2018. https://doi.org/10.14740/jocmr3556w
- M. Brownlee, "Glycation products and the pathogenesis of diabetic complications," Diabetes Care, Vol.15, No.12, pp.1835-1843, 1992. https://doi.org/10.2337/diacare.15.12.1835
- L. E. Garcia-Perez, M. Alvarez, T. Dilla, V. Gil-Guillen, and D. Orozco-Beltran, "Adherence to therapies in patients with type 2 diabetes," Diabetes Ther, Vol.4, No.2, pp.175-194, 2013. https://doi.org/10.1007/s13300-013-0034-y
- R. Boussageon, T. Bejan-Angoulvant, M. Saadatian-Elahi, S. Lafont, C. Bergeonneau, B. Kassai, S. Erpeldinger, J. M. Wright, F. Gueyffier, and C. Cornu, "Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: metaanalysis of randomised controlled trials," BMJ, Vol.343, p.d4169, 2011. https://doi.org/10.1136/bmj.d4169
- W. Duckworth, C. Abraira, T. Moritz, D. Reda, N. Emanuele, P. D. Reaven, F. J. Zieve, J. Marks, S. N. Davis, R. Hayward, S. R. Warren, S. Goldman, M. McCarren, M. E. Vitek, W. G. Henderson, G. D. Huang, and V. Investigators, "Glucose control and vascular complications in veterans with type 2 diabetes," N Engl J Med, Vol.360, No.2, pp.129-139, 2009. https://doi.org/10.1056/NEJMoa0808431
- F. B. Hu, M. J. Stampfer, C. G. Solomon, S. Liu, W. C. Willett, F. E. Speizer, D. M. Nathan, and J. E. Manson, "The impact of diabetes mellitus on mortality from all causes and coronary heart disease in women: 20 years of follow-up," Archives of internal medicine, Vol.161, No.14, pp.1717-1723, 2001. https://doi.org/10.1001/archinte.161.14.1717
- W. B. Kannel, "Lipids, diabetes, and coronary heart disease: insights from the Framingham Study," Am Heart J, Vol.110, No.5, pp.1100-1107, 1985. https://doi.org/10.1016/0002-8703(85)90224-8
- R. M. Krauss and P. W. Siri, "Dyslipidemia in type 2 diabetes," Med Clin North Am, Vol.88, No.4, pp.897-909, 2004. https://doi.org/10.1016/j.mcna.2004.04.004
- S. J. Hamilton and G. F. Watts. "Endothelial dysfunction in diabetes: pathogenesis, significance, and treatment," Rev Diabet Stud, Vol.10, No.2-3, pp.133-156, 2013. https://doi.org/10.1900/RDS.2013.10.133
- S. Natarajan, Y. Liao, D. Sinha, G. Cao, D. L. McGee, and S. R. Lipsitz, "Sex differences in the effect of diabetes duration on coronary heart disease mortality," Arch Intern Med, Vol.165, No.4, pp.430-435, 2005. https://doi.org/10.1001/archinte.165.4.430
- S. G. Wannamethee, A. G. Shaper, P. H. Whincup, L. Lennon, and N. Sattar, "Impact of diabetes on cardiovascular disease risk and all-cause mortality in older men: influence of age at onset, diabetes duration, and established and novel risk factors," Arch Intern Med, Vol.171, No.5, pp.404-410, 2011. https://doi.org/10.1001/archinternmed.2011.2
- E. B. Schroeder, L. E. Chambless, D. Liao, R. J. Prineas, G. W. Evans, W. D. Rosamond, G. Heiss, and S. Atherosclerosis Risk in Communities, "Diabetes, glucose, insulin, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) study," Diabetes Care, Vol.28, No.3, pp.668-674, 2005. https://doi.org/10.2337/diacare.28.3.668
- A. Gottsater, A. R. Ahlgren, S. Taimour, and G. Sundkvist, "Decreased heart rate variability may predict the progression of carotid atherosclerosis in type 2 diabetes," Clin Auton Res, Vol.16, No.3, pp.228-234, 2006. https://doi.org/10.1007/s10286-006-0345-4