References
- Walter P and Ron D (2011) The unfolded protein response: from stress pathway to hemeostatic regulation. Science 334, 1081-1086 https://doi.org/10.1126/science.1209038
- Young SK and Wek RC (2016) Upstream open reading frames differentially regulate gene-specific translation in the integrated stress response. J Biol Chem 291, 16927-16935 https://doi.org/10.1074/jbc.R116.733899
- Sonenberg N and Hinnebusch AG (2009) Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731-745 https://doi.org/10.1016/j.cell.2009.01.042
- Chang KJ and Wang CC (2004) Translation initiation from a naturally occurring non-AUG codon in Saccharomyces cerevisiae. J Biol Chem 279, 13778-13785 https://doi.org/10.1074/jbc.M311269200
- Starck SR, Jiang V, Pavon-Eternod M, Prasad S, McCarthy B, Pan T and Shastri N (2012) Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I. Science 336, 1719-1723 https://doi.org/10.1126/science.1220270
- Jedrychowski MP, Wrann CD, and Paulo JA et al (2015) Detection and quantitation of circulating human irisin by tandem mass specrometry. Cell Metab 22, 734-740 https://doi.org/10.1016/j.cmet.2015.08.001
- Starck SR, Tsai JC, and Chen K et al (2016) Translation from the 5' untranslated regions shapes the integrated stress response. Science 351, aad3867 https://doi.org/10.1126/science.aad3867
- Dmitriev SE, Terenin IM, and Andreev DE et al (2010) GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. J Biol Chem 285, 26779-26787 https://doi.org/10.1074/jbc.M110.119693
- Holcik M (2015) Could the eIF2a-independent translation be the achilles heel of cancer? Front Oncol 5, 264
- Weisser M, Schafer T, Leibundgut M, Bohringer D, Aylett CHS and Ban N (2017) Structural and functional insights into human re-initiation complexes. Mol Cell 67, 447-456 https://doi.org/10.1016/j.molcel.2017.06.032
- Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF and Hinnebusch AG (1992) Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates genespecific translational control of GCN4 in yeast. Cell 68, 585-596 https://doi.org/10.1016/0092-8674(92)90193-G
- Shi Y, Vattem KM, and Sood R et al (1998) Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol 18, 7499-7509 https://doi.org/10.1128/MCB.18.12.7499
- Harding HP, Zhang Y and Ron D (1999) Protein translation and folding are coupled by an endoplasmicreticulum- resident kinase. Nature 397, 271-274 https://doi.org/10.1038/16729
- Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP, Ron D (2003) Stress-induced gene expression requires programmed recovery from translational repression. EMBO J 22, 1180-1187 https://doi.org/10.1093/emboj/cdg112
- Marciniak SJ, Yun CY, and Oyadomari S et al (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18, 3066-3077 https://doi.org/10.1101/gad.1250704
- Lee YY, Cevallos RC and Jan E (2009) An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. J Biol Chem 284, 6661-6673 https://doi.org/10.1074/jbc.M806735200
- Malzer E, Szajewska-Skuta M, and Dalton LE et al (2013) Coordinate regulation of eIF2alpha phosphorylation by PPP1R15 and GCN2 is required during Drosophila development. J Cell Sci 126, 1406-1415 https://doi.org/10.1242/jcs.117614
- Harding HP, Novoa I, and Zhang Y et al (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6, 1099-1108 https://doi.org/10.1016/S1097-2765(00)00108-8
- Zhou D, Palam LR, Jiang L, Narasimhan J, Staschke KA and Wek RC (2008) Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. J Biol Chem 283, 7064-7073 https://doi.org/10.1074/jbc.M708530200
- Palam LR, Baird TD and Wek, RC (2011) Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem 286, 10939-10949 https://doi.org/10.1074/jbc.M110.216093
- Baird TD, Palam LR, and Fusakio ME et al (2014) Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKalpha. Mol Biol Cell 25, 1686-1697 https://doi.org/10.1091/mbc.e14-02-0704
- Andreev DE, O'Connor PB, and Fahey C et al (2015) Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. eLife 4, e03971
- Young SK, Willy JA, Wu C, Sachs MS and Wek RC (2015) Ribosome reinitiation directs gene-specific translation and regulates the integrated stress response. J Biol Chem 290, 28257-28271 https://doi.org/10.1074/jbc.M115.693184
- Young SK, Baird TD and Wek RC (2016) Translation regulation of the glutamyl-prolyl-tRNA synthetase gene EPRS through bypass of upstream open reading frames with noncanonical initiation codons. J Biol Chem 291, 10824-10835 https://doi.org/10.1074/jbc.M116.722256
- Willy JA, Young SK, and Mosley AL et al (2017) Function of inhibitor of brutons tyrosine kinase isoform a (IBTKa) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response. J Biol Chem 292, 14050-14065 https://doi.org/10.1074/jbc.M117.799304
- Hinnebusch AG, Ivanov IP and Sonenberg N (2016) Translational control by 5'-untranslated regions of eukaryotic mRNAs. Science 352, 1413-1416 https://doi.org/10.1126/science.aad9868
- Hinnebusch AG (1984) Evidence for translational regulation of the activator of general amino acid control in yeast. Proc Natl Acad Sci U S A 81, 6442-6446 https://doi.org/10.1073/pnas.81.20.6442
- Preston AM and Hendershot LM (2013) Examination of a second node of translational control in the unfolded protein response. J Cell Sci 126, 4253-4261 https://doi.org/10.1242/jcs.130336
- Brunn GJ, Fadden P, Haystead TA and Lawrence JC Jr (1997) The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. J Biol Chem 272, 32547-32550 https://doi.org/10.1074/jbc.272.51.32547
- Burnett PE, Barrow RK, Cohen NA, Snyder SH and Sabatini DM (1998) RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A 95, 1432-1437 https://doi.org/10.1073/pnas.95.4.1432
- Fadden P, Haystead TA and Lawrence JC Jr (1997) Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. J Biol Chem 272, 10240-10247 https://doi.org/10.1074/jbc.272.15.10240
- Yamaguchi S, Ishihara H, and Yamada T et al (2008) ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metab 7, 269-276 https://doi.org/10.1016/j.cmet.2008.01.008
- Kang MJ, Vasudevan D, and Kang K et al (2017) 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging. J Cell Biol 216, 115-129 https://doi.org/10.1083/jcb.201511073
- Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS and Sabatini DM (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485, 109-113 https://doi.org/10.1038/nature11083
- Hsieh AC, Liu Y, and Edlind MP et al (2012) The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485, 55-61 https://doi.org/10.1038/nature10912
- Pelletier J and Sonenberg N (1988) Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334, 320-325 https://doi.org/10.1038/334320a0
- Jang SK, Krausslich HG, Nicklin MJ, Duke GM, Palmenberg AC and Wimmer E (1988) A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol 62, 2636-2643
- Etchison D, Milburn SC, Edery I, Sonenberg N and Hershey JW (1982) Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 200,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex. J Biol Chem 257, 14806-14810
- Hernandez G, Vazquez-Pianzola P, Sierra JM and Rivera-Pomar R (2004) Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos. RNA 10, 1783-1797 https://doi.org/10.1261/rna.7154104
- Riley A, Jordan LE and Holcik M (2010) Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress. Nucleic Acids Res 38, 4665-4674 https://doi.org/10.1093/nar/gkq241
- Lee AS, Kranzusch PJ, Doudna JA and Cate JH (2016) eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature 536, 96-99 https://doi.org/10.1038/nature18954
- Meyer KD, Patil DP, and Zhou J et al (2015) 5' UTR m(6)A promotes cap-independent translation. Cell 163, 999-1010 https://doi.org/10.1016/j.cell.2015.10.012
- Zhou J, Wan J, Gao X, Zhang X, Jaffrey SR and Qian SB (2015) Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 526, 591-594 https://doi.org/10.1038/nature15377
- Henis-Korenblit S, Strumpf NL, Goldstaub D and Kimchi A (2000) A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. Mol Cell Biol 20, 496-506 https://doi.org/10.1128/MCB.20.2.496-506.2000
- Marash L, Liberman N, and Henis-Korenblit S et al (2008) DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis. Mol Cell 30, 447-459 https://doi.org/10.1016/j.molcel.2008.03.018
- Bukhari SIA, Truesdell SS, and Lee S et al (2016) A specialized mechanism of translation mediated by FXR1a-associated microRNP in cellular quiescence. Mol Cell 61, 760-773 https://doi.org/10.1016/j.molcel.2016.02.013
- Henis-Korenblit S, Shani G, Sines T, Marash L, Shohat G and Kimchi A (2002) The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc Natl Acad Sci U S A 99, 5400-5405 https://doi.org/10.1073/pnas.082102499
- Nevins TA, Harder ZM, Korneluk RG and Holcik M (2003) Distinct regulation of internal ribosome entry sitemediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4G1 and p97/DAP5/NAT1. J Biol Chem 278, 3572-3579 https://doi.org/10.1074/jbc.M206781200
- Warnakulasuriyarachchi D, Cerquozzi S, Cheung HH and Holcik M (2004) Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element. J Biol Chem 279, 17148-17157 https://doi.org/10.1074/jbc.M308737200
- Lewis SM, Cerquozzi S, Graber TE, Ungureanu NH, Andrews M and Holcik M (2008) The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress. Nucleic Acids Res 36, 168-178
- Kozutsumi Y, Segal M, Normington K, Gething M-J and Sambrook J (1988) The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332, 462-464 https://doi.org/10.1038/332462a0
- Cox JS, CE Shamu and P Walter (1993) Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197-1206 https://doi.org/10.1016/0092-8674(93)90648-A
- Ryoo HD, Domingos PM, Kang MJ, Steller H (2007) Unfolded protein response in a Drosophila model for retinal degeneration. EMBO J 26, 242-252 https://doi.org/10.1038/sj.emboj.7601477
- Sarnow P (1989) Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNA is inhibited. Proc Natl Acad Sci U S A 86, 5795-5799 https://doi.org/10.1073/pnas.86.15.5795
- Macejak DG and Sarnow P (1991) Internal initiation of translation mediated by the 5' leader of a cellular mRNA. Nature 353, 90-94 https://doi.org/10.1038/353090a0
- Fernandez J, Yaman I, and Merrick WC et al (2002) Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame. J Biol Chem 277, 2050-2058 https://doi.org/10.1074/jbc.M109199200
- Fernandez J, Bode B, and Koromilas A et al (2002) Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase- dependent manner. J Biol Chem 277, 11780-11787 https://doi.org/10.1074/jbc.M110778200
- Hinnebusch AG, Jackson BM and Mueller PP (1988) Evidence for regulation of reinitiation in translational control of GCN4 mRNA. Proc Natl Acad Sci U S A 85, 7279-7283 https://doi.org/10.1073/pnas.85.19.7279
Cited by
- against corticosterone-induced neuronal damage via the AKT and ERK1/2 pathway vol.51, pp.8, 2018, https://doi.org/10.5483/BMBRep.2018.51.8.099
- The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration pp.1559-1182, 2019, https://doi.org/10.1007/s12035-018-1286-3
- IRES Trans-Acting Factors, Key Actors of the Stress Response vol.20, pp.4, 2019, https://doi.org/10.3390/ijms20040924