BMB Reports
- Volume 50 Issue 11
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- Pages.537-538
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- 2017
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- 1976-670X(eISSN)
DOI QR Code
Hypoxia suffocates histone demethylases to change gene expression: a metabolic control of histone methylation
- Park, Hyunsung (Department of Life Science, University of Seoul)
- Received : 2017.09.30
- Published : 2017.11.30
Abstract
Hypoxia affects various physiological and pathophyological processes. Hypoxia changes the expression of hypoxia-responsive genes through two main pathways. First, hypoxia activates transcription factors (TF) such as Hypoxia-inducible Factor (HIF). Second, hypoxia decreases the activity of Jumonji C domain-containing histone demethylases (JMJDs) that require