The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

장기간 한약 복용한 뇌졸중 환자의 간 및 신장 기능 수치 변화에 대한 증례 보고

  • Kim, Geun-yeob (Dept. of Korean Internal Medicine, College of Korean Medicine, Se-Myung University) ;
  • Kim, Gi-tae (Dept. of Korean Internal Medicine, College of Korean Medicine, Se-Myung University) ;
  • Go, Ho-yeon (Dept. of Korean Internal Medicine, College of Korean Medicine, Se-Myung University) ;
  • Ko, Heung (Dept. of Korean Internal Medicine, College of Korean Medicine, Se-Myung University) ;
  • Shin, Seon-mi (Dept. of Korean Internal Medicine, College of Korean Medicine, Se-Myung University)
  • 김근엽 (세명대학교 한의과대학 내과학교실) ;
  • 김기태 (세명대학교 한의과대학 내과학교실) ;
  • 고호연 (세명대학교 한의과대학 내과학교실) ;
  • 고흥 (세명대학교 한의과대학 내과학교실) ;
  • 신선미 (세명대학교 한의과대학 내과학교실)
  • Received : 2017.09.08
  • Accepted : 2017.10.29
  • Published : 2017.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This case report describes a patient who had suffered a stroke and who was treated for a long period with herbal medicine in combination with a Western medicine. Methods: Changes in liver function and renal function laboratory tests were measured while the patient took herbal medicine during the 1190 days of hospitalization. Results: During the hospitalization period, the liver function test (LFT) levels were elevated two fold, but after taking the herbal medicine, the LFT levels were stabilized and have remained stable since. Conclusions: The high risk of prescribing herbal medicine by an unlicensed person and the possibility of long-term herbal medicine usage for stabilizing liver function test were shown.

Keywords

References

  1. Lee WM, Senior JR. Recognizing drug-induced liver injury: Current problem, possible solution. Toxicol Pathol 2005;33(1):155-64. https://doi.org/10.1080/01926230590522356
  2. Cheon UJ, Yun BG, Kim NI, Lee G, Yang CH, Lee CU, et al. A Clinical Study of Patients with Acute Liver Injury Caused by Herbal Medication in Gyeongju Area. Clinical and Molecular Hepatology 2002;8(2):2287-728.
  3. Baek JT, Kim MS, Kang SB, Lee SK, Jang YH, Lee KM, at el. Over the past five years, Causal Trends of adult acute hepatitis in Daejeon area. Korean J Med 1999;57(2):352.
  4. Park BK, Jung TU, Cho JH, Son CG. A Case of Acute Liver Injury Caused by Comfrey and so on with Oriental Medicine. Korean J Orient Int Med 2009;30(1):249-55.
  5. Seo JC, Jeon WJ, Park SS, Lee GM, Chae HB, Park SM, et al. Clinical Experience of 48 Acute Toxic Hepatitis Patients. Korean Journal of Hepatology 2006;12(1):74-81.
  6. Jang JW, Song SJ, Kim JY, Min SS, Kim KK, Hwang WD. The consequences of Longperiod Dosages of Herbal Medicine Including Boo-ja and Cheon-o on Liver Injury. Journal of Korean oriental internal medicine 2005;26(4):828-35.
  7. Ha JY, Baik TH, Lee JB. Effects of Sihosamutang on the $CCl_4$-induced Liner Damage in Rats. Korean J Oriental Medical Pathology 1997;11(2):27-36.
  8. Kim SK, Kim HH, An JH, Kim JD, Kim CH. Effect of Artemisia Capillaris Fructus on Fas-FasL-induced Apoptosis in Hepatocyte. Journal of Korean oriental internal medicine 2001;22(3):353-60.
  9. Lee E, Park BW, Hea GJ, Ko H. A Study on The Side Effects and Toxicity of Herbal Medicine. Korean J Orient int med 2000;21(5):869-72.
  10. Lee WM, Senior JR. Recognizing drug-induced liver injury: Current problem, possible solution. Toxicol Pathol 2005;33(1):155-64. https://doi.org/10.1080/01926230590522356
  11. Benichou C. Criteria of drug-induced liver disorders-Report of an International Consensus Meeting. J Hepatol 1990;11:272-6. https://doi.org/10.1016/0168-8278(90)90124-A
  12. Chae HB. Clinical Manifestations and Diagnosis of drug-induced liver injury. Korean Journal of Hepatology 2004;10(1):7-18.
  13. Co-work professor of Korean internal medicine. Internal Medicine-Gan's System. Seoul: Oriental Medicine Research Center; 2001, p. 801-7.
  14. Kim JC, Park HM, Cho HS, Park JH, Lee JE, Song CH, et al. Comparison of liver function test score by herbal medication duration. Korean J Orienh int med 2005;aut(1):37-45.
  15. Lee SH, Lee MS, Song MD. One case of the hepatic injury suggested toxic hepatitis(drug induced hepatitis) in the treatment of oriental medicine for cerebral infarction. Korean J Orient int med 2000;21(5):869-72.
  16. Yoon YK, Sun TC, Jang HJ, Song WS. A Clinical Case of Liver Injury Induced by Chungsim Yeonja-tang. Korean J Orient int med 2004;25(3):539-44.
  17. Choi HS, Jeong TY. One Case of Drug-Induced Liver Injury Treated with Saenggangeonbi-tang. J of Korean oriental internal medicine 2004;25(4):207-11.
  18. Hwang DY. Bangyaghabpyeon. Seoul: yeonglimsa; 2002, p. 311, 242, 259, 170.
  19. Benichou C. Criteria of Dur-induced liver disorders. Repor of an international consensus meeting. J Hepatol 1990;11:272-6. https://doi.org/10.1016/0168-8278(90)90124-A
  20. Liu C, Fan H, Li Y, Xiao X. Research Advances on Hepatotoxicity of Herbal Medicines in China. Biomed Research International 2016;2016(1):1-14.
  21. Gangyenaegwahaggyosil. Gangyenaegwaha. sixth edition. Seoul: Nado; 2015, p. 926.
  22. Lee E, Ko H. Saenggangeonbi-tang's Effect on Alcoholic Liver Cirrhosis-1 Case. J Korean Orienatal Med 2003;21(3):213-9.
  23. Hwang SJ. Effects of Saengkankeonbi-tang on prevention of hyperlipidemia and liver damage induced by alcohol. Department of Oriental Internal Medicine Graduate School Daegu Haany University 2009:10-27.
  24. Hartleb M, Biernat L, Kochel A. Drug-induced liver damage-a three year study of patients from one gastroenterological department. Med Sci Monit 2002;8(4):292-6.
  25. Cho JH, Oh DS, Hong SH, Ko H, Lee NH, Park SE, et al. A nationwide study of the incidence rate of herb-induced liver injury in Korea Arch Toxicol 2007(10):DOI 10.1007/s00204-017-2007-9