DOI QR코드

DOI QR Code

A Study on Development of Composite Ultrasonic Transducer Assembly with Drug Transfer Function

약물 이송기능을 갖는 복합구조 초음파 변환기 어셈블리 개발에 관한 연구

  • Noh, Si-Cheol (Department of Radiological Science, International University of Korea) ;
  • Kim, Ju-Young (School of Biomedical Engineering, Inje University) ;
  • Yoo, Byeong-Cheol (IPS research center, Waseda University) ;
  • Jung, Bong-Jae (Department of Radiological Science, International University of Korea)
  • 노시철 (한국국제대학교 방사선학과) ;
  • 김주영 (인제대학교 의용공학부) ;
  • 유병철 (와세다대학교 IPS 연구센터) ;
  • 정봉재 (한국국제대학교 방사선학과)
  • Received : 2017.08.24
  • Accepted : 2017.10.31
  • Published : 2017.10.31

Abstract

The sonophoresis, a representative low-intensity ultrasonic therapy, is a technique for delivering the drugs into the epidermis, dermis and skin appendages by using physical vibration and heat effects of the ultrasonic waves. Sonophoresis could increases the delivering and absorption efficiency of the drugs usually consisting of hydrophilic molecules and macromolecules. In addition, it has the advantage of being effective in delivering drugs with relatively large molecular sizes such as insulin or lipid. In this study, we proposed a multi-structure ultrasonic transducer assembly with a large-size single piezoelectric element and a drug delivery function at the treatment site for efficient sonophoresis treatment. Futhermore, a transducer assembly structure capable of raising and maintaining the temperature of the treatment site was proposed and evaluated for effectiveness. The transducer assembly proposed in this study is expected to improve the efficiency of sonophoresis by providing a constant amount of drug, and assisting drug delivery through heating the treatment site.

대표적인 저강도 초음파 자극 기술인 음파영동은 초음파의 물리적 진동과 온열 효과를 이용하여 약물을 인체 표피 내부로 전달시키는 기법이다. 음파영동법은 치료 약물 전달의 효율을 높일 수 있으며, 인슐린이나 지질 등 분자 크기가 비교적 큰 약물의 전달에도 효과적이라는 장점을 갖는다. 본 연구에서는 효율적인 음파영동 치료를 위하여 대면적 단일 진동소자와 치료 부위에 약물 이송 기능을 갖는 복합 구조 초음파 변환기 어셈블리를 제안하였다. 또한, 치료 부위의 온도를 상승 및 유지시킬 수 있는 변환기 어셈블리 구조를 제안하고 유효성을 평가하였다. 본 연구에서 제안된 변환기 어셈블리는 지속적으로 정량의 약물을 제공하고, 가온을 통하여 약물 전달을 보조함으로써 초음파를 이용한 음파영동 시술의 효율을 향상시킬 수 있을 것으로 사료된다.

Keywords

References

  1. C. A. Speed, "Therapeutic ultrasound in soft tissue lesions." Rheumatology, Vol. 40, No. 12, pp. 1331-1336, 2001. https://doi.org/10.1093/rheumatology/40.12.1331
  2. S. B. Barnett, G. R. Ter Haar, M. C. Ziskin, W. L. Nyborg, K. Maeda, J. Bang, "Current status of research on biophysical effects of ultrasound." Ultrasound in medicine & biology, Vol. 2, No. 3, pp. 205-218, 1994.
  3. S. B. Tajali, P. Houghton, J. C. MacDermid, R. Grewal, "Effects of low-intensity pulsed ultrasound therapy on fracture healing: a systematic review and meta-analysis." American journal of physical medicine & rehabilitation, Vol. 91, No. 4, pp. 349-367, 2012. https://doi.org/10.1097/PHM.0b013e31822419ba
  4. Mitragotri, Samir, Daniel Blankschtein, and Robert Langer. "Transdermal drug delivery using low-frequency sonophoresis." Pharmaceutical research, Vol. 13, No. 3, pp. 411-420, 1996. https://doi.org/10.1023/A:1016096626810
  5. Al-Bataineh, Osama M., Khaldon Lweesy, and Loay Fraiwan. "In-vivo evaluation of a noninvasive transdermal insulin delivery system utilizing ultrasound transducers." Journal of Medical Imaging and Health Informatics, Vol. 1, No. 3, pp. 267-270, 2011. https://doi.org/10.1166/jmihi.2011.1039
  6. Alvarez-Roman, Rocio, et al. "Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways." Journal of pharmaceutical sciences, Vol. 92, No. 6, pp. 1138-1146, 2003. https://doi.org/10.1002/jps.10370
  7. Boucaud, A., et al. "In vitro study of low-frequency ultrasound-enhanced transdermal transport of fentanyl and caffeine across human and hairless rat skin." International journal of pharmaceutics, Vol. 228, No. 1, pp. 69-77, 2001. https://doi.org/10.1016/S0378-5173(01)00820-1
  8. Wang, Yiping, et al. "Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery." European Journal of Pharmaceutics and Biopharmaceutics, Vol. 60, No. 2, pp. 179-191, 2005. https://doi.org/10.1016/j.ejpb.2004.12.008