The Effect of Increase in Length and Volume of Source in Radioactive Iodine Thyroid Uptake Rate

갑상선 섭취율 측정에서 선원의 길이와 부피 증가에 따른 영향

  • Hwang, Dong Hun (Dept. of Nuclear Medicine, Severance Hospital, Yonsei University Health System) ;
  • Oh, Shin Hyun (Dept. of Nuclear Medicine, Severance Hospital, Yonsei University Health System) ;
  • Kim, Jung Yul (Dept. of Nuclear Medicine, Severance Hospital, Yonsei University Health System) ;
  • Kang, Chun Koo (Dept. of Nuclear Medicine, Severance Hospital, Yonsei University Health System) ;
  • Kim, Jae Sam (Dept. of Nuclear Medicine, Severance Hospital, Yonsei University Health System)
  • 황동훈 (연세의료원 세브란스병원 핵의학과) ;
  • 오신현 (연세의료원 세브란스병원 핵의학과) ;
  • 김정열 (연세의료원 세브란스병원 핵의학과) ;
  • 강천구 (연세의료원 세브란스병원 핵의학과) ;
  • 김재삼 (연세의료원 세브란스병원 핵의학과)
  • Received : 2017.04.28
  • Accepted : 2017.05.10
  • Published : 2017.05.20

Abstract

Purpose Radioactive iodine thyroid uptake (RAIU) rate is an examination which determines and seeks about general functions of thyroid gland. The size of thyroid gland is normally different between each person, also patients having thyroid diseases have had a variety of size of thyroid gland compared with others. The purpose of this study will investigate about the counting rate which is effected by the geometric factors through the length and volume changes of the source in RAIU rate. Materials and Methods I-131 185 kBq ($5{\mu}Ci$) were placed in a cylindrical phantom of 0.5 cm, 1 cm, 1.5 cm, and 3 cm in diameter, respectively, and saline was added to gradually increase the length by 1 cm in the horizontal and vertical directions to give a change in volume. The source was measured 20 times for 20 seconds from a distance of 25 cm to $364.4keV{\pm}20%$ energy ROI with Captus 3000 thyroid uptake system (Capintec, NJ, USA). Results When the source was located in the transverse direction of the detector, the consequence of one-way ANOVA is that even though the length of source is increased each diameter, there is mostly no significant difference. When the source was located in the longitudinal direction and the counting rate of length 1 cm at all diameter is set to 100%, the average is 92.57% for length 2 cm, 86.1% for 3 cm, 80.69% for 4 cm, 74.82% for 5 cm, and 69.68% at 6 cm. Conclusion According to this study, it is expected that the gap of RAIU rate has been depended on the thickness of thyroid gland as well as the diameter of the beaker. We know that the change of the volume with the increase of the length of the source had less effect on the change of the counting rate. Thus, in order to reduce the error in the measurement of the counting rate with the thyroid uptake rate equipment, an accurate counting rate can be relatively measured if the counting rate which is measured is corrected by thickness or the distance between the thyroid and the thyroid uptake rate equipment is changed.

방사성 요오드 갑상선 섭취율 검사는 방사성 요오드를 투여하고 일정 시간 후 갑상선의 요오드 방사능치를 측정하여 전반적인 기능 상태를 알아보는 검사법이다. 검사에 영향을 미치는 인자는 매우 다양하다. 본 연구에서는 갑상선의 길이나 두께, 부피에 따른 기하학적 요인이 계수율에 주는 영향을 관찰하고자 한다. 액체상태의 $^{131}I\;185kBq$ ($5{\mu}Ci$)을 지름이 0.5, 1, 1.5, 3 cm 인 주사기에 넣고 길이를 1 cm 간격으로 생리식염수를 추가하여 증가시켰다. 선원을 장비로부터 25 cm 거리에서 횡축방향과 종축방향으로 위치하였을 때 각각의 계수율을 측정하였다. 횡축 방향으로 위치하였을 때, 선원의 길이가 변화하여도 대부분 유의한 차이를 보이지 않았다. 종축 방향으로 위치하였을 때, 곡선추정 회귀분석 결과 복합모형곡선과 높은 상관관계를 보였고($$R^2{\geq_-}0.941$$), 선원의 길이가 증가할수록 계수율은 감소하였다. 따라서 갑상선 섭취율 검사 시, 갑상선의 가로나 세로 방향의 차이에 따른 섭취율의 오차는 적을 것으로 예상되어 지며, 단순한 부피의 차이보다 갑상선의 두께 및 투여 전 선량측정 시의 비커에 따라서 오차가 생길 수 있다고 예상된다. 따라서 오차를 줄이기 위해서는 초음파 등의 영상을 참고하여 두께를 구해 섭취율 수치에 적용하거나, 결과에서 구한 복합방정식을 통해 오차를 예측, 갑상선과 섭취율 장비의 거리를 변화시킨다면 비교적 정확한 계수율을 구할 수 있을 거라 사료 된다.

Keywords

References

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