Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antioxidant Activity and NO Inhibitory Effect of Bioconverted Medicinal Material Using Germinated Green Rice and Hericium erinaceus Mycelium

발아녹미와 노루궁뎅이 버섯 균사체를 이용한 생물전환 약용 신소재의 항산화 활성 및 NO 생성 억제 효능

  • 이영민 (건국대학교 의생명화학전공) ;
  • 김인숙 (건국대학교 의생명화학전공) ;
  • 미툰 고쉬 (건국대학교 의생명화학전공) ;
  • 홍성민 (건국대학교 의생명화학전공) ;
  • 이택환 (안국건강연구소) ;
  • 이동희 ((재)경북바이오산업연구원) ;
  • 임병우 (건국대학교 의생명화학전공)
  • Received : 2017.07.28
  • Accepted : 2017.08.30
  • Published : 2017.10.30
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Abstract

Background: Hericium erinaceus is considered a functional food and potential medicinal source. The present study was conducted to examine the potential antioxidant and anti-inflammatory activities of carried out with water and ethanol extracts of Hericium erinaceus grown on germinated green rice (HEGR-W and HEGR-E, respectively) and the water and ethanol extracts of germinated green rice (GR-W and GR-E, respectively) as potential medicinal resources or antioxidant and anti-inflammatory agents. Methods and Results: The total phenolic and flavonoid contents, DPPH, and ABTS activity, reducing power, DNA protective activity, cell viability, and NO production were investigated. The total phenolic and flavonoid contents were highest in HEGR-E ($66.53{\pm}2.40 mg{\cdot}GAE/100g$ and $82.12{\pm}7.10mg{\cdot}CE/100g$ respectively). HEGR-E exhibited high DPPH ($44.70{\pm}1.28%$) and, ABTS ($44.70{\pm}1.28%$) activity and reducing power (0.219). HEGR and GR extracts showed protective activity against DNA damage. The cytotoxicity of HEGR and GR in RAW264.7 cells and LPS-induced RAW264.7 cells was low. HEGR-E and GR-W exhibited anti-inflammatory effects through a 28% inhibition of NO production in LPS-induced RAW264.7 cells. Conclusions: These results suggested that the extracts of Hericium erinaceus grown on germinated green rice could be a potential medicinal material with natural antioxidant and NO inhibitory properties.

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References

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