Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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CT Quantification of Lungs and Airways in Normal Korean Subjects

  • Kim, Song Soo (Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Jin, Gong Yong (Department of Radiology, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Chonbuk National University Medical School, Institute of Medical Science) ;
  • Li, Yuan Zhe (Department of Radiology, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Lee, Jeong Eun (Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Shin, Hye Soo (Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine)
  • Received : 2016.08.15
  • Accepted : 2017.01.05
  • Published : 2017.08.01
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Abstract

Objective: To measure and compare the quantitative parameters of the lungs and airways in Korean never-smokers and current or former smokers ("ever-smokers"). Materials and Methods: Never-smokers (n = 119) and ever-smokers (n = 45) who had normal spirometry and visually normal chest computed tomography (CT) results were retrospectively enrolled in this study. For quantitative CT analyses, the low attenuation area (LAA) of $LAA_{I-950}$, $LAA_{E-856}$, CT attenuation value at the 15th percentile, mean lung attenuation (MLA), bronchial wall thickness of inner perimeter of a 10 mm diameter airway (Pi10), total lung capacity ($TLC_{CT}$), and functional residual capacity ($FRC_{CT}$) were calculated based on inspiratory and expiratory CT images. To compare the results between groups according to age, sex, and smoking history, independent t test, one way ANOVA, correlation test, and simple and multiple regression analyses were performed. Results: The values of attenuation parameters and volume on inspiratory and expiratory quantitative computed tomography (QCT) were significantly different between males and females (p < 0.001). The MLA and the 15th percentile value on inspiratory QCT were significantly lower in the ever-smoker group than in the never-smoker group (p < 0.05). On expiratory QCT, all lung attenuation parameters were significantly different according to the age range (p < 0.05). Pi10 in ever-smokers was significantly correlated with forced expiratory volume in 1 second/forced vital capacity (r = -0.455, p = 0.003). In simple and multivariate regression analyses, $TLC_{CT}$, $FRC_{CT}$, and age showed significant associations with lung attenuation (p < 0.05), and only $TLC_{CT}$ was significantly associated with inspiratory Pi10. Conclusion: In Korean subjects with normal spirometry and visually normal chest CT, there may be significant differences in QCT parameters according to sex, age, and smoking history.

Keywords

Acknowledgement

Supported by : Dongkook Pharm. Co., Ltd.

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