Pediatric Gastroenterology, Hepatology & Nutrition

  • 제20권3호
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  • Pages.167-177
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  • 2017
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  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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Safety of a New Synbiotic Starter Formula

  • Vandenplas, Yvan (Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel) ;
  • Analitis, Antonis (Department of Hygiene, Epidemiology and Medical Statistics, Faculty of Medicine, National and Kapodistrian University of Athens) ;
  • Tziouvara, Chara (3rd Pediatric Department, Hippocration Hospital) ;
  • Kountzoglou, Athina (3rd Pediatric Department, Hippocration Hospital) ;
  • Drakou, Anastasia (3rd Pediatric Department, Hippocration Hospital) ;
  • Tsouvalas, Manos (3rd Pediatric Department, Hippocration Hospital) ;
  • Mavroudi, Antigoni (3rd Pediatric Department, Hippocration Hospital) ;
  • Xinias, Ioannis (3rd Pediatric Department, Hippocration Hospital)
  • 투고 : 2017.03.13
  • 심사 : 2017.04.24
  • 발행 : 2017.09.30
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초록

Purpose: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. Methods: The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months. Results: The median age of the infants at inclusion was 0.89 months. Weight evolution was in accordance with the World Health Organization growth charts for exclusive breastfed infants. The evolution of all anthropometric parameters (weight-for-length z score and body mass index-for-age z score) was within the normal range. The incidence of functional constipation (3.2%), daily regurgitation (10.9%), infantile crying and colic (10.5%) were all significantly lower than the reported median prevalence for a similar age according to literature (median value of 7.8% for functional constipation, 26.7% for regurgitation, 17.7% for infantile colic). Conclusion: The new synbiotic infant starter formula was safe, resulted in normal growth and was well tolerated. Functional gastro-intestinal manifestations (functional constipation, regurgitation and colic) were significantly lower than reported in literature. Synbiotics (Bifidobacterium lactis and fructo-oligosaccharides) in cow's milk based infant formula bring the second choice infant feeding, formula, closer to the golden standard, exclusive breastfeeding.

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참고문헌

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