Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Biochemical mechanism of the ratio of omega 6 to 3 fatty acid on blood lipid reduction in rats

랫드에서 혈액지질 감소에 관한 오메가 6와 3 지방산 비율의 생화학적 메카니즘

  • Lee, Seung-Hyung (College of Animal Life Science, Kangwon National University) ;
  • Kim, Jin-Soo (College of Animal Life Science, Kangwon National University) ;
  • Choi, Du-Hyeong (College of Animal Life Science, Kangwon National University) ;
  • Kim, Chang-Rae (College of Animal Life Science, Kangwon National University) ;
  • Um, Kyung-Hwan (College of Animal Life Science, Kangwon National University) ;
  • Park, Byung-Sung (College of Animal Life Science, Kangwon National University)
  • 이승형 (강원대학교 동물생명과학대학) ;
  • 김진수 (강원대학교 동물생명과학대학) ;
  • 최두형 (강원대학교 동물생명과학대학) ;
  • 김창래 (강원대학교 동물생명과학대학) ;
  • 엄경환 (강원대학교 동물생명과학대학) ;
  • 박병성 (강원대학교 동물생명과학대학)
  • Received : 2017.05.26
  • Accepted : 2017.06.28
  • Published : 2017.06.30
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Abstract

This study was investigated the biochemical mechanism on reducing blood lipids in second-generation rats fed diet with different omega 6 to omega 3 fatty acid ratio. The experiment treatment groups were classified into the groups with the omega 6 to omega 3 ratios of 0 (control group), 1:1, 8:1, and 19:1, respectively. The levels of the blood triglyceride, total cholesterol, low density lipoprotein-cholesterol (LDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and glucose were lowest in the group with the omega 6 to omega 3 ration of 1:1. The levels of high density lipoprotein-cholesterol and phospholipid were highest in the group with the omega 6 to omega 3 ration of 1:1. The HMG-CoA reductase activity was suppressed in the groups with the omega 6 to omega 3 ratio of 1:1 and 8:1 compared with that in the control group, but the excretion of sterol through feces was promoted. The blood omega 6 to omega 3 ratio decreased in a concentration-dependent manner depending on the increase in the omega 6 to omega 3 ratio within the ingested diet. The results of this study demonstrated a new finding that when the parent generation and second-generation rats ingested the diet with the omega 6 to omega 3 ratio of below 8:1, harmful lipids in the blood were reduced, the liver functions were maintained, and the growth was promoted due to the nutrient metabolism activation mechanism.

본 연구는 차세대 랫드에서 혈액 지질 감소에 관한 식이 내 오메가 6와 3 지방산 비율의 생화학적 메카니즘을 조사하였다. 실험처리군은 오메가 6:오메가 3비율 0 (대조구), 1:1, 8:1, 19:1로 구분하였다. 혈액 중성지방, 총콜레스테롤, 저밀도지질단백질(LDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose의 수준은 오메가 6:오메가 3 비율 1:1 그룹에서 가장 낮았다. 혈액 고밀도지질단백질(HDL-C), 인지질의 수준은 오메가 6:오메가 3 비율 1:1 그룹이 가장 높았다. HMG-CoA reductase activity는 전체 저리구 가운데 오메가 6:오메가 3 비율 1:1, 8:1 그룹에서 가장 강하게 억제되었으나 분을 통한 스테롤의 배설량은 촉진되었다. 혈액 오메가 6:오메가 3 비율은 섭취한 식이 내 오메가 6:오메가 3 비율 증가에 따른 농도 의존적으로 감소하였다. 본 연구결과는 부모 세대로부터 차세대 랫드에 이르기까지 오메가 6:오메가 3 비율이 8:1 이하로 낮아진 식이를 섭취하면 영양소 대사작용 활성화 메카니즘에 의한 혈액 중 유해지질 감소, 간 기능 유지 및 성장을 자극한다는 새로운 사실을 나타낸다.

Keywords

References

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