참고문헌
- Brem G, Hartl P, Besenfelder U, Wolf E, Zinovieva N, Pfaller R (1994): Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits. Gene 149:351-355. https://doi.org/10.1016/0378-1119(94)90175-9
- Clark AJ, Burl S, Denning C, Dickinson P (2000): Gene targeting in livestock: a preview. Transgenic Res 9:263-275. https://doi.org/10.1023/A:1008974616402
- Gaj T, Gersbach CA, Barbas CF 3rd (2013): ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol 31:397-405. https://doi.org/10.1016/j.tibtech.2013.04.004
- Houdebine LM (2000): Transgenic animal bioreactors. Transgenic Research 9:305-320. https://doi.org/10.1023/A:1008934912555
- Houdebine LM (2009): Production of pharmaceutical proteins by transgenic animals. Comp Immunol Microbiol Infect Dis 32:107-121. https://doi.org/10.1016/j.cimid.2007.11.005
-
Jeong YH, Kim YJ, Kim EY, Kim SE, Kim J, Park MJ, Lee HG, Park SP, Kang MJ (2015): Knock-in fibroblasts and transgenic blastocysts for expression of human FGF2 in the bovine
${\beta}$ -casein gene locus using CRISPR/Cas9 nuclease-mediated homologous recombination. Zygote 24:442-456. - Kim SE, Park DS, Koo DB, Kang MJ (2017): Knockin efficiency depending on homologous arm structure of the knock-in vector in the bovine fibroblasts. Reprod Dev Biol 41:7-16. https://doi.org/10.12749/RDB.2017.41.1.7
- Liu X, Wang Y, Guo W, Chang B, Liu J, Guo Z, Quan F, Zhang Y (2013): Zinc-finger nickase-mediated insertion of the lysostaphin gene into the betacasein locus in cloned cows. Nat Commun 4:2565. https://doi.org/10.1038/ncomms3565
-
Liu X, Wang Y, Tian Y, Yu Y, Gao M, Hu G, Su F, Pan S, Luo Y, Guo Z, Quan F, Zhang Y (2014): Generation of mastitis resistance in cows by targeting human lysozyme gene to
${\beta}$ -casein locus using zincfinger nucleases. Proc R Soc B 281:20133368 https://doi.org/10.1098/rspb.2013.3368 - Muller U (1999): Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis. Mech Dev 82:3-21. https://doi.org/10.1016/S0925-4773(99)00021-0
- McCreath KJ, Howcroft J, Campbell KHS, Colman A, Schnieke AE, Kind AJ (2000): Production of gene-targeted sheep by nuclear transfer from cultured somatic cells. Nature 29:1066-1069.
- Shen W, Lan G, Yang X, Li L, Min L, Yang Z, Tian L, Wu X, Sun Y, Chen H, Tan J, Deng J, Pan Q (2007): Targeting the exogenous htPAm gene on goat somatic cell beta-casein locus for transgenic goat production. Mol Reprod Dev 74:428-434. https://doi.org/10.1002/mrd.20595
- Yanez RJ, Porter AC (1998): Therapeutic gene targeting. Gene Ther 5:149-159. https://doi.org/10.1038/sj.gt.3300601
- Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D (2002): Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110:771-781. https://doi.org/10.1172/JCI0215463
- Zinovieva N, Lassnig C, Schams D, Besenfelder U, Wolf E, Muller S, Frenyo L, Seregi J, Muller M, Brem G (1998): Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations. Transgenic Res 7:437-447. https://doi.org/10.1023/A:1008831028620