대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)

  • 제49권3호
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  • Pages.227-232
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  • 2017
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  • 1738-3544(pISSN)
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  • 2288-1662(eISSN)
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)
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물 섭취에 의한 혈액 성분 변화에 관한 연구

Changes in the Blood Components Caused by Water Intake

  • 김현경 (김천대학교 임상병리학과) ;
  • 김수환 (김천대학교 임상병리학과) ;
  • 류재기 (김천대학교 임상병리학과)
  • Kim, Hyun-Kyung (Department of Biomedical Laboratory Science, College of Natural Science, Gimcheon University) ;
  • Kim, Soo-Hwan (Department of Biomedical Laboratory Science, College of Natural Science, Gimcheon University) ;
  • Ryu, Jae-Ki (Department of Biomedical Laboratory Science, College of Natural Science, Gimcheon University)
  • 투고 : 2017.07.28
  • 심사 : 2017.08.25
  • 발행 : 2017.09.30
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초록

물은 생체에 필수적인 성분이고 많은 생리학적 과정에 관련되어 있음에도 불구하고 물을 꾸준히 충분하게 섭취하는 것이 혈액 성분에 어떤 영향을 미치는지에 대해서는 잘 알려져 있지 않다. 따라서 이 연구에서는 13명의 정상 성인에게 물을 섭취하게 한 후에 혈액학적, 고감도 C 반응성 단백질(hs-CRP), 면역글로불린 G (IgG)의 변화를 측정하였다. 4명의 대조군은 물을 자유롭게 마시게 하였고 9명의 실험군은 시판되는 생수를 매일 2L씩 마시게 하였다. 2주 후에 혈액을 채취하여 검사한 결과, 혈구 세포 수, 적혈구 용적률, 혈색소 수치는 증가했지만 유의성은 없었다(p>0.05). 그러나 평균 혈색소량(MCH)과 평균 혈색소 농도(MCHC)는 각각 의미 있게 증가하였고(p<0.05, p<0.01), 평균 혈소판 용적(MPV)은 의미 있게 감소하였다(p<0.05). 심혈관 질환의 표지자로 쓰이는 면역학적인 검사항목인 hs-CRP는 물 섭취 후에 감소하는 것으로 나타났으나 유의한 차이는 없었다(p>0.05). 그러나 IgG의 농도는 물 섭취 전에 비해 상당히 유의성 있게 증가하는 결과를 나타냈다(p<0.05). 결론적으로, 꾸준히 충분하게 물을 섭취하면 혈색소 수치가 증가하여 빈혈이 완화될 수 있고 혈소판 활성과 hs-CRP가 감소하여 심혈관 질환의 위험을 줄일 수 있다. 또한 체액성 면역 성분이 증가하여 면역 기능이 향샹될 수 있다.

Although water is an essential component of the human body and is involved in many physiological processes, the effect of a steady and sufficient water intake on blood components has not well elucidated. Therefore, we investigated the changes in hematological parameters, high-sensitivity C-reactive protein (hs-CRP), and immunoglobulin G (IgG) after water intake in 13 healthy adults. They were divided into two groups: The control group (N=4), which consumed water ad libitum, and the experimental group (N=9), which consumed 2 L of water per day. Two weeks later, blood cell counts, hematocrit, and hemoglobin content had increased in the experimental group, although not significantly (p>0.05); however, there was a significant increase in the mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) (p<0.05; and p<0.01, respectively), and a significant decrease in the mean platelet volume (MPV) (p<0.05). Of the immunologic parameters, a non-significant decrease in the concentration of hs-CRP, an indicator of cardiovascular disease risk, was observed (p>0.05). However, there was a dramatic and significant increase in the concentration of IgG (p<0.05). In conclusion, a steady and sufficient water intake may contribute to alleviate anemia by increasing hemoglobin. Additionally, it may decrease the risk of cardiovascular disease by decreasing platelet activation and concentration of hs-CRP. Furthermore, a steady intake of water may improve immune function by increasing the concentration of the components of humoral immunity.

키워드

참고문헌

  1. Rodak BF Frisma GA, Keohane EM. Hematology: Clinical principles and applications. 4th ed. Missouri: Elesevier; 2012. p1-6.
  2. Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Pract. 2005;59(8): 981-982. https://doi.org/10.1111/j.1742-1241.2005.00500.x
  3. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8(1):148-156. https://doi.org/10.1111/j.1538-7836.2009.03584.x
  4. Dantzer R, Kelley KW. Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun. 2007; 21(2):153-160. https://doi.org/10.1016/j.bbi.2006.09.006
  5. Shanahan L, Bauldry S, Freeman J, Bondy CL. Self-rated health and C-reactive protein in young adults. Brain Behav Immun. 2014;36:139-146. https://doi.org/10.1016/j.bbi.2013.10.020
  6. Koh JM, Khang YH, Jung CH, Bae S, Kim DJ, Chung YE, et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int. 2005;16(10):1263-1271. https://doi.org/10.1007/s00198-005-1840-5
  7. Soriano-Guillen L, Hernandez-Garcia B, Pita J, Dominguez-Garrido N, Del Rio-Camacho G, Rovira A. High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents. Eur J Endocrinol. 2008;159(1): R1-4. https://doi.org/10.1530/EJE-08-0212
  8. Schwab I, Nimmerjahn F. Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Nat Rev Immunol. 2013;13(3):176-189. https://doi.org/10.1038/nri3401
  9. Kaneko Y, Nimmerjahn F, Ravetch JV. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science. 2006;313(5787):670-673. https://doi.org/10.1126/science.1129594
  10. Jequier E, Constant F. Water as an essential nutrient: the physiological basis of hydration. Eur J Clin Nutr. 2010;64(2): 115-123. https://doi.org/10.1038/ejcn.2009.111
  11. Popkin BM, D'Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev. 2010;68(8):439-458. https://doi.org/10.1111/j.1753-4887.2010.00304.x
  12. Colombo MF, Rau DC, Parsegian VA. Protein solvation in allosteric regulation: a water effect on hemoglobin. Science. 1992;256(5057):655-659. https://doi.org/10.1126/science.1585178
  13. Bulone D, San Biagio PL, Palma-Vittorelli MB, Palma MU. The role of water in hemoglobin function and stability. Science. 1993;259(5099):1335-1336. https://doi.org/10.1126/science.8446903
  14. Roth GA, Huffman MD, Moran AE, Feigin V, Mensah GA, Naghavi M, et al. Global and regional patterns in cardiovascular mortality from 1990 to 2013. Circulation. 2015;132(17):1667-1678. https://doi.org/10.1161/CIRCULATIONAHA.114.008720
  15. Oksak GA, Golovanova IA. Contribution of mortality from cardiovascular disease to overall mortality. Wiad Lek. 2017;70(3 pt 1):449-455.
  16. Bhatti AB, Ali F, Satti SA. Relationship of hypertensive retinopathy with mean platelet volume among hypertensive patients. Cureus. 2015;7(12):e422.
  17. Jung BG, Lee JA, Lee BJ. Oxygenated drinking water enhances immune activity in pigs and increases immune responses of pigs during Salmonella typhimurium infection. J Vet Med Sci. 2012;74(12):1651-1655. https://doi.org/10.1292/jvms.12-0051
  18. Shin D, Cho ESR, Bang HT, Shim KS. Effects of oxygenated or hydrogenated water on growth performance, blood parameters, and antioxidant enzyme activity of broiler chickens. Poult Sci. 2016;95(11):2679-2684. https://doi.org/10.3382/ps/pew237
  19. Ballow M. Primary immunodeficiency disorders: antibody deficiency. J Allergy Clin Immunol. 2002;109(4):581-591. https://doi.org/10.1067/mai.2002.122466
  20. Ramos-Medina R, Corbi AL, Sanchez-Ramon S. Intravenous immunoglobulin: immunomodulatory key of the immune system. Med Clin (Barc). 2012;139(3):112-117. https://doi.org/10.1016/j.medcli.2011.11.022
  21. Imbach P, Barandun S, d'Apuzzo V, Baumgartner C, Hirt A, Morell A, et al. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood.Lancet. 1981; 1(8232):1228-1231.

피인용 문헌

  1. 여대생의 건강체력과 비만에 대한 물과 커피 섭취량과의 관계 vol.37, pp.4, 2020, https://doi.org/10.12925/jkocs.2020.37.4.649
  2. A Longitudinal Study of Hematology and Stress Biomarker Profiles in Young Asian Elephants (Elephas Maximus) in Relation to Elephant Endotheliotropic Herpesvirus (EEHV) in Thailand vol.11, pp.9, 2017, https://doi.org/10.3390/ani11092530