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생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer

  • Wang, Xiaokun (Department of Cell Biology, School of Basic Medical Science, Peking University) ;
  • Xia, Yan (Department of Immunology, School of Basic Medical Science, Peking University) ;
  • Xu, Chentong (Department of Immunology, School of Basic Medical Science, Peking University) ;
  • Lin, Xin (Department of Immunology, School of Basic Medical Science, Peking University) ;
  • Xue, Peng (College of China-Japan Friendship Hospital, Beijing University of Chinese Medicine) ;
  • Zhu, Shijie (Department of Oncology, Wangjing Hospital, China Academy of Chinese Medical Sciences) ;
  • Bai, Yun (Department of Cell Biology, School of Basic Medical Science, Peking University) ;
  • Chen, Yingyu (Department of Immunology, School of Basic Medical Science, Peking University)
  • 투고 : 2017.04.19
  • 심사 : 2017.06.23
  • 발행 : 2017.08.31
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초록

The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored.

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참고문헌

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