Journal of Microbiology and Biotechnology

  • 제27권8호
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  • Pages.1457-1460
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  • 2017
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Inhibitory Effects of Flavonoids from Spatholobus suberectus on Sortase A and Sortase A-Mediated Aggregation of Streptococcus mutans

  • Park, Wanki (Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University) ;
  • Ahn, Chan-Hong (Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University) ;
  • Cho, Hyunjoo (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Kim, Chang-Kwon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Shin, Jongheon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Oh, Ki-Bong (Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University)
  • 투고 : 2017.04.03
  • 심사 : 2017.06.13
  • 발행 : 2017.08.28
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초록

Seven flavonoids were isolated from Spatholobus suberectus via repetitive column chromatography and high-performance liquid chromatography. The chemical structures of these compounds were identified by spectroscopic analysis and comparison with values reported in the literature. Among the flavonoids tested, 7-hydroxy-6-methoxyflavanone (1) and formononetin (4) exhibited strong inhibitory activity against Streptococcus mutans SrtA, with $IC_{50}$ values of 46.1 and $41.8{\mu}M$, respectively, but did not affect cell viability. The onset and magnitude of inhibition of saliva-induced aggregation in S. mutans treated with compounds 1 and 4 were comparable to the behavior of a srtA-deletion mutant without treatment.

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참고문헌

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