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Investigation of Dose Distribution in Mixed Neutron-Gamma Field of Boron Neutron Capture Therapy using N-Isopropylacrylamide Gel

  • Received : 2016.03.27
  • Accepted : 2016.07.30
  • Published : 2017.02.25

Abstract

Gel dosimeters have unique advantages in comparison with other dosimeters. Until now, these gels have been used in different radiotherapy techniques as a reliable dosimetric tool. Because dose distribution measurement is an important factor for appropriate treatment planning in different radiotherapy techniques, in this study, we evaluated the ability of the N-isopropylacrylamide (NIPAM) polymer gel to record the dose distribution resulting from the mixed neutron-gamma field of boron neutron capture therapy (BNCT). In this regard, a head phantom containing NIPAM gel was irradiated using the Tehran Research Reactor BNCT beam line, and then by a magnetic resonance scanner. Eventually, the $R_2$ maps were obtained in different slices of the phantom by analyzing T2-weighted images. The results show that NIPAM gel has a suitable potential for recording three-dimensional dose distribution in mixed neutron-gamma field dosimetry.

Keywords

References

  1. T. Yamamoto, K. Tsuboi, K. Nakai, H. Kumada, H. Sakurai, A. Matsumura, Boron neutron capture therapy for brain tumors, Transl. Cancer Res. 2 (2013) 80-86.
  2. International Atomic Energy Agency, Current Status of Neutron Capture Therapy, International Atomic Energy Agency, Austria, 2001.
  3. A. Khajeali, A.R. Farajollahi, R. Khodadadi, Y. Kasesaz, A. Khalili, Role of gel dosimeters in boron neutron capture therapy, Appl. Radiat. Isot 103 (2015) 72-81. https://doi.org/10.1016/j.apradiso.2015.05.017
  4. M.C. Hsiao, W.L. Chen, P.E. Tsai, C.K. Huang, Y.H. Liu, H.M. Liu, S.H. Jiang, A preliminary study on using the radiochromic film for 2D beam profile QC/QA at the THOR BNCT facility, Appl. Radiat. Isot 69 (2011) 1915-1917. https://doi.org/10.1016/j.apradiso.2011.04.007
  5. T. Schmitz, N. Bassler, M. Blaickner, M. Ziegner, M.C. Hsiao, Y.H. Liu, H. Koivunoro, I. Auterinen, T. Seren, P. Kotiluoto, H. Palmans, P. Sharpe, P. Langguth, G. Hampel, The alanine detector in BNCT dosimetry: dose response in thermal and epithermal neutron fields, Med. Phys 42 (2015) 400.
  6. C. Aschan, M. Toivonen, S. Savolainen, T. Seppala, I. Auterinen, Epithermal neutron beam dosimetry with thermoluminescence dosemeters for boron neutron capture therapy, Radiat. Prot. Dosimetry 81 (1999) 47-56. https://doi.org/10.1093/oxfordjournals.rpd.a032569
  7. C. Baldock, Y. De Deene, S. Doran, G. Ibbott, A. Jirasek, M. Lepage, K.B. McAuley, M. Oldham, L.J. Schreiner, Polymer gel dosimetry, Phys. Med. Biol 55 (2010) R1-R63. https://doi.org/10.1088/0031-9155/55/5/R01
  8. G. Gambarini, S. Arrigoni, M. Bonardi, M.C. Cantone, D. deBartolo, S. Desiati, L. Facchielli, A.E. Sichirollo, A system for 3-D absorbed dose measurements with tissueequivalence for thermal neutrons, Nucl. Instrum. Methods Phys. Res. A 353 (1994) 406-410. https://doi.org/10.1016/0168-9002(94)91686-1
  9. G. Gambarini, C. Birattari, D. Monti, M.L. Fumagalli, A. Vai, P. Salvadori, L. Facchielli, A.E. Sichirollo, Fricke-infused agarose gel phantoms for NMR dosimetry in boron neutron capture therapy and proton therapy, Radiat. Prot. Dosimetry 70 (1997) 571-575. https://doi.org/10.1093/oxfordjournals.rpd.a032019
  10. G. Gambarini, S. Agosteo, M. Carrara, S. Gay, M. Mariani, L. Pirola, E. Vanossi, In-phantom dosimetry for BNCT with Fricke and normoxic-polymer gels, J. Phys. Conf. Ser 41 (2006) 275. https://doi.org/10.1088/1742-6596/41/1/029
  11. A.R. Farajollahi, D.E. Bonnett, D. Tattam, S. Green, The potential use of polymer gel dosimetry in boron neutron capture therapy,, Phys. Med. Biol. 45 (2000) N9. https://doi.org/10.1088/0031-9155/45/4/401
  12. J. Uusi-Simola, S. Savolainen, A. Kangasmaki, S. Heikkinen, J. Perkio, U.A. Ramadan, T. Seppala, J. Karila, T. Seren, P. Kotiluoto, P. Sorvari, I. Auterinen, Study of the relative dose-response of BANG-3$^{(R)}$ polymer gel dosimeters in epithermal neutron irradiation, Phys. Med. Biol 48 (2003) 2895. https://doi.org/10.1088/0031-9155/48/17/310
  13. A. Khajeali, A.R. Farajollahi, Y. Kasesaz, R. Khodadadi, A. Khalili, A. Naseri, Capability of NIPAM polymer gel in recording dose from the interaction of 10 B and thermal neutron in BNCT, Appl. Radiat. Isot 105 (2015) 257-263. https://doi.org/10.1016/j.apradiso.2015.08.028
  14. R.J. Senden, P.D. Jean, K.B. McAuley, L.J. Schreiner, Polymer gel dosimeters with reduced toxicity: a preliminary investigation of the NMR and optical dose-response using different monomers, Phys. Med. Biol 51 (2006) 3301. https://doi.org/10.1088/0031-9155/51/14/001
  15. W.S. Snyder, M.R. Ford, G.G. Warner, H. Fisher Jr., Estimates of Absorbed Fractions for Monoenergetic Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom, Oak Ridge National Lab., Tenn., 1969.
  16. E. Bavarnegin, H. Khalafi, A. Sadremomtaz, Y. Kasesaz, Construction of a head phantom for mixed neutron and gamma field dosimetry in TRR, Measurement 89 (2016) 145-150. https://doi.org/10.1016/j.measurement.2016.03.070
  17. I. Auterinen, T. Seren, K. Anttila, A. Kosunen, S. Savolainen, Measurement of free beam neutron spectra at eight BNCT facilities worldwide, Appl. Radiat. Isot 61 (2004) 1021-1026. https://doi.org/10.1016/j.apradiso.2004.05.035
  18. Y.-W. Liu, T. Huang, S. Jiang, H. Liu, Renovation of epithermal neutron beam for BNCT at THOR, Appl. Radiat. Isot 61 (2004) 1039-1043. https://doi.org/10.1016/j.apradiso.2004.05.042
  19. G. Ke, Z. Sun, F. Shen, T. Liu, Y. Li, Y. Zhou, The study of physics and thermal characteristics for in-hospital neutron irradiator (IHNI),, Appl. Radiat. Isot 67 (2009) S234-S237. https://doi.org/10.1016/j.apradiso.2009.03.117
  20. Y. Kasesaz, H. Khalafi, F. Rahmani, A. Ezati, M. Keyvani, A. Hossnirokh, M.A. Shamami, M. Monshizadeh, A feasibility study of the Tehran research reactor as a neutron source for BNCT, Appl. Radiat. Isot 90 (2014) 132-137. https://doi.org/10.1016/j.apradiso.2014.03.028
  21. Y. Kasesaz, H. Khalafi, F. Rahmani, Design of an epithermal neutron beam for BNCT in thermal column of Tehran research reactor, Ann. Nucl. Energy 68 (2014) 234-238. https://doi.org/10.1016/j.anucene.2014.01.014
  22. Y. Kasesaz, H. Khalafi, F. Rahmani, A. Ezzati, M. Keyvani, A. Hossnirokh, M.A. Shamami, S. Amini, Design and construction of a thermal neutron beam for BNCT at Tehran Research Reactor, Appl. Radiat. Isot 94 (2014) 149-151. https://doi.org/10.1016/j.apradiso.2014.08.004
  23. Y. Kasesaz, E. Bavarnegin, M. Golshanian, A. Khajeali, H. Jarahi, S. Mirvakili, H. Khalafi, BNCT project at Tehran Research Reactor: current and prospective plans, Prog. Nucl. Energy 91 (2016) 107-115. https://doi.org/10.1016/j.pnucene.2016.04.010
  24. F. Pak, A. Farajollahi, A. Movafaghi, A. Naseri, Influencing factors on reproducibility and stability of MRI NIPAM polymer gel dosimeter, BioImpacts 3 (2013) 163.
  25. A.R. Farajollahi, F. Pak, M. Horsfield, Z. Myabi, The basic radiation properties of the N-isopropylacrylamide based polymer gel dosimeter, Int. J. Radiat. Res 12 (2014) 347-354.
  26. A.R. Farajollahi, D.E. Bonnett, D. Tattam, S. Green, The potential use of polymer gel dosimetry in boron neutron capture therapy, Phys. Med. Biol 45 (2000) N9-N14. https://doi.org/10.1088/0031-9155/45/4/401
  27. G. Gambarini, A. Negri, V. Regazzoni, D. Magni, R. Nolli, F. Campi, J. Burian, M. Marek, V. Klupak, L. Viererbl, Methods for dose measurements in small phantoms irradiated at BNCT epithermal column, Appl. Radiat. Isot 88 (2014) 118-124. https://doi.org/10.1016/j.apradiso.2013.11.093
  28. E. Vanossi, M. Carrara, G. Gambarini, A. Negri, M. Mariani, In-phantom dose imaging with polymer gel layer dosimeters, Appl. Radiat. Isot 67 (2009) S195-S198. https://doi.org/10.1016/j.apradiso.2009.03.048
  29. G. Gambarini, C. Birattari, C. Colombi, L. Pirola, G. Rosi, Fricke gel dosimetry in boron neutron capture therapy, Radiat. Prot. Dosimetry 101 (2002) 419-422. https://doi.org/10.1093/oxfordjournals.rpd.a006015
  30. J. Uusi-Simola, S. Heikkinen, P. Kotiluoto, T. Seren, T. Seppala, I. Auterinen, S. Savolainen, MAGIC polymer gel for dosimetric verification in boron neutron capture therapy, J. Appl. Clin. Med. Phys 8 (2007) 114-123.

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