Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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Analysis of Hematological Factor to Predict of the Gallbladder Stone in Abdominal Ultrasound Images

복부초음파 영상에서 담낭담석을 예측하는 혈액학적 수치의 분석

  • An, Hyun (Department of Radiology, Inje University Busan Paik Hospital) ;
  • Hwang, Chul-Hwan (Department of Radiation Oncology, Pusan National University Hospital) ;
  • Im, In-chul (Department of Radiological Science, Dong Eui University of Pusan)
  • 안현 (인제대학교 부산 백병원 영상의학과) ;
  • 황철환 (부산대학병원 방사선종양학과) ;
  • 임인철 (동의대학교 방사선학과)
  • Received : 2017.04.28
  • Accepted : 2017.06.30
  • Published : 2017.06.30
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Abstract

This study investigated the risk factor of Gallbladder stone in Busan and Kyungnam area. The subjects of the experiment was performed with patients by abdominal ultrasonography among the patients who came to the P hospital from June 2016 to December 2016. Among them, risk factors were analyzed on 353 people at the same time when abdominal ultrasonography and hematological test. The statistical analysis of risk factors related to the Gallbladder stone was performed by independent t-test and chi-square test. In consider of difference verification result for calculations odds ratio about independent variables, multiple logistic regression analysis to conduct verify adequacy by calculating forecasting model from variable. As a result, Gallbladder stone risk factors have relevance to age ${\gamma}GTP$ with probability model and values to calculated. Age was showed sensitivity 49.7%, specificity 82.2%, receiver operating characteristic area under curve 0.724. Forecasting probability sensitivity 69.3%, specificity 62.4%, receiver operating characteristic area under curve 0.699 showed, ${\gamma}GTP$ confirmed validity of forecasting model.

본 연구는 부산 경남지역의 담낭담석의 위험인자를 알아보고자 하였다. 실험대상은 2016년 6월~12월까지 2016년 12월까지 부산 P병원을 내원하여 복부초음파를 실시한 대상으로 하였다. 그 중 복부초음파와 혈청학적 검사를 동시에 실시한 353명을 대상으로 위험인자를 분석하였다. 초음파 검사 상 담낭담석과 관련있는 위험인자들의 통계분석은 독립표본 t검정(independent t-test)과 카이제곱 검정(chi-square test)을 시행하였다. 차이검정 결과를 고려하여 독립변수에 대한 상대 위험비(odds ratio, OR) 산출을 위해 다중 로지스틱 회귀분석(multiple logistic regression analysis)을 시행하여 변수들로부터 예측모형을 산정하여 타당성을 검정하였다. 그 결과 담낭담석 위험인자로 확인된 연령, ${\gamma}GTP$로 예측모형 및 예측 확률값을 산출하였다. 연령에서 민감도 49.7%, 특이도 82.2%를 보였으며, ROC 곡선하면적이 0.724를 나타내었다. ${\gamma}GTP$에서는 민감도 69.3%, 특이도 62.4%를 보였으며, ROC 곡선하면적이 0.699를 나타내어 예측모형의 타당성을 확인할 수 있었다.

Keywords

References

  1. S. B. Lee, H. C. Kang, Y. T. Shin, J. H. Lee, S. I. Choi, C. O. Kim, H. J. Hwang, "Prevalence of Gallbladder stone in Adults in Korea," Korean Journal of Family Medicine, Vol. 30, No. 1, pp. 39-45, 2009. https://doi.org/10.4082/kjfm.2009.30.1.39
  2. F. Angelico, del M. Ben, A. Barbato, R. Conti, G. Urbinati, "Ten year incidence and natural history of gallstone disease in a rural population of women in central Italy," Italian journal of gastroenterology and hepatology, Vol. 29, No. 3, pp. 249-254, 1997.
  3. L. Barbara, C. Sama, Morselli A. M. Labate, F. Taroni, A. G. Rusticali, D. Festi, C. Sapio, E. Roda, C. Banterle, A. Puci, "A population study on the prevalence of gallstone disease: the Sirmione Study," Hepatology, Vol. No. 7, pp. 913-917, 1987.
  4. M. Y. Berger, J. J. van der Velden, J. G. Lijmer, H. de Kort, A. Prins, A. M. Bohnen, "Abdominal symptoms: do they predict gallstones?: a systematic review," Scandinavian Journal of Gastroenterology, Vol. 35, No. 1, pp. 70-76, 2000. https://doi.org/10.1080/003655200750024560
  5. K. S. Yoo, "Diagnosis of gallstone," Korean Journal of Medicine, Vol. 75, No. 6, pp. 616-623, 2008.
  6. H. Volzke, S. E. Baumeister, D. Alte, W. Hoffmann, C. Schwahn, P. Simon, U. John, M. M. Lerch, "In dependent risk factors for gallstone formation in a region with high cholelithiasis prevalence," Digestion, Vol. 71, No. 2, pp. 97-105, 2005. https://doi.org/10.1159/000084525
  7. S. Y. Yi, S. K. Lee, S. K. Lee, Y. I. Min, M. H. Kim, D. S. Han, J. W. Kim, "Clinical Study on Gallstone Prevalence in General Health Screening People," Korean Journal of Medicine, Vol. 47, No. 3, pp. 352-358, 1994.
  8. Y. J. Chung, Y. D. Park, H. C. Lee, H. J. Cho, K. S. Park, E. H. Seo, S. W. Jeon, C. M. Cho, W. Y. Tak, Y. O. Kweon, S. K. Kim, Y. H. Choi, J. S. Kim, H. J. Lee, J. M. Chung, "Prevalence and risk factors of gallstones in a general health screened population," Korean Journal of Medicine, Vol. 72, No. 5, pp. 480-490, 2007.
  9. A. F. Attili, N. Carulli, E. Roda, B. Barbara, L. Capocaccia, L. Menotti Aokoliksanyi, G. Ricci, R. Capocaccia, D. Festi et al. "Epidemiology of gallstone disease in Italy:prevalence data of the Multicenter italian study on cholelithiasis(M.I.COL)," American Journal of Epidemiology, Vol. 141, No. 2, pp. 158-165, 1995. https://doi.org/10.1093/oxfordjournals.aje.a117403
  10. H. W. Jung, K. S. Cheon, Y. S. Kim, M. H. Kim, H. Y. Choi, "Prevalence of gallstones in Korean," Korean Journal of Family Medicine, Vol. 13, No. 7, pp. 581-591, 1992.
  11. C. Y. Chen, C. L. Lu, Y. S. Huang, T. N. Tam, Y. Chao, S. D. Lee, "Age is one of the risk factors in developing gallstone disease in Taiwan," Age and Ageing, Vol. 27, No. 4, pp. 437-441, 1998. https://doi.org/10.1093/ageing/27.4.437
  12. Y. M. Moon, "Biliary Stone in Korea," The Korean Journal of Gastroenterology, Vol. 19, No. 1, pp. 1-5, 1987.
  13. T. Jorgensen, "Prevalence of gallstones in a Danish population," American Journal of Epidemiology, Vol. 126, No. 5, pp. 912-921, 1987. https://doi.org/10.1093/oxfordjournals.aje.a114728
  14. T. Orgensen, L. Kay, K. Schultz-Larsen, "The epidemiology of gallstones in a 70-year-old Danish population," Scandinavian Journal of Gastroenterology, Vol. 25, No. 4, pp. 335-340, 1990. https://doi.org/10.3109/00365529009095495
  15. F. Angelico, M. del Ben, A. Barbato, R. Conti, G. Urbinati, "Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy," Italian journal of gastroenterology and hepatology, Vol.29, No.3, pp.249-254, 1997
  16. A. K. Diehl, N. J. Sugarek, K. H. Todd, "Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis," American Journal of Medicine, Vol. 89, No. 1, pp. 29-33, 1990. https://doi.org/10.1016/0002-9343(90)90094-T
  17. J. Lee, "Clinical features and diagnosis of gallstones, " Damdohak, koonja publishing company, 1st ed, pp. 189-210, 2008
  18. B. I. Choi, J. G. Han, "Radiological diagnosis of gallstones," Korean Society of Gastroenterological Surgery 3, Gallstone disease, 1st ed, koonja publishing company, pp.133-152, 1999.
  19. K. Tsunoda, Y. Shirai, K. Hatakeyama, "Prevalence of cholesterol gallstones positively correlates with per capita daily calorie intake," Hepatogastroenterology, Vol. 51, No. 59, pp. 1271-1274, 2004.
  20. S. W. Hwang, J. H.. Yang, B. L. Cho, B. Y. Huh, S. W. Ou, H. J. Lee, S. Y. Lim, "Original Articles; Associated factor of prevalence of asymptomatic gallstone," Korean Journal of Family Medicine, Vol. 22, No. 11, pp. 1596-1602, 2001.