Natural Product Sciences

  • 제23권2호
  • /
  • Pages.97-102
  • /
  • 2017
  • /
  • 1226-3907(pISSN)
  • /
  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지
DOI QR코드

DOI QR Code

Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

  • Kwon, Yongsoo (College of Pharmacy, Kangwon National University) ;
  • Kim, Hyun Pyo (College of Pharmacy, Kangwon National University) ;
  • Kim, Myong Jo (College of Agriculture and Life science, Kangwon National University) ;
  • Chun, Wanjoo (School of Medicine, Kangwon National University)
  • 투고 : 2016.12.15
  • 심사 : 2017.01.24
  • 발행 : 2017.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin (5), geijerine (6), (-)-3'-acetyl hamaudol (7), 7-demethylsuberosine (8), dehydrogeijerin (9), (-)-hamaudol (10), (+)-visamminol (11), divaricatol (12), scopoletin (13), and decursidate (14), respectively. Among them, compounds 4-6, 8, 9, 13, and 14 were isolated for the first time from A. polymorpha. Dehydrogeijerin (6) and geijerin (9) were isolated for the first time from genus Angelica. All isolates tested for inhibitory activity against acetylcholinesterae. Compounds 1 to 13 showed acetylcholinesterase inhibitory activity with $IC_{50}$ values ranging from 1.4 to $37.5{\mu}M$.

키워드

참고문헌

  1. Lee, W. T. Standard illustrations of Korean plants; Academy Pub. Co.: Seoul, 1996, p 254.
  2. Editorial Committee of Zhong Hua Ben Cao of State Administration of Traditional Chinese Medicine of People's Republic of China. Zhong Hua Ben Cao; Shanghai Science and Technology Press: Shanghai, 1999, pp 892-893.
  3. Yang, Y.; Zhang Y.; Ren, F. X.; Yu, N. J.; Xu, R.; Zhao, Y. M. Yao Xue Xue Bao, 2013, 48, 718-722.
  4. Yang, S. J.; Yao, Q. Q.; Li, Y. N.; Chen, X. X.; Cui, S. X.; Bai, S. Y.; Wang, F. L. J. Asian Nat. Prod. Res. 2012, 14, 76-79. https://doi.org/10.1080/10286020.2011.631181
  5. Dan, F. J.; Chu, L. J.; Tian, Y.; Dong, J. X.; Cai, Z. J. Shizhen Guoyi Guoyao 2011, 22, 299-300.
  6. Yang, Y.; Yu, N.; Zhang, Y.; Ren, F.; Zhang, A.; Zhao Y. Zhongguo Yaoxue Zazhi 2010, 45, 1320-1323.
  7. Yang, Y.; Yu, N.; Liang, F.; Zhang, Y.; Ren, F. X.; Zhang, A.; Zhao, Y. Pharm. J. Chin. PLA. 2010, 26, 189-191.
  8. Han, S.; Bai, S. Y.; Yang, S. J. J. Jining Med. Univ. 2010, 33, 13-14.
  9. Li, Y.; Yang, S.; Bai, S. Zhongguo Zhong Yao Za Zhi 2009, 34, 854-857.
  10. Pachaly, P.; Kroll-Horstmann, A.; Sin, K. S. Pharmazie 2000, 55, 777-778.
  11. Coyle, J. T.; Price, D. L.; DeLong, M. R. Science 1983, 219, 1184-1190. https://doi.org/10.1126/science.6338589
  12. Mukherjoo, P. K.; Kumar, V.; Mal, M.; Houghton, P. J. Phytomedicine 2007, 14, 289-300. https://doi.org/10.1016/j.phymed.2007.02.002
  13. Houghton, P. J.; Ren, Y.; Howes, M. J. Nat. Prod. Rep. 2006, 23, 181-199. https://doi.org/10.1039/b508966m
  14. Anand, P.; Singh, B. Arch. Pharm. Res. 2013, 36, 375-399. https://doi.org/10.1007/s12272-013-0036-3
  15. Ellman, G. L.; Courtney, K. D.; Andres Jr., V.; Feather-Stone, R. M. Biochem. Pharmacol. 1961, 7, 88-95. https://doi.org/10.1016/0006-2952(61)90145-9
  16. Kim, S. J.; Chin, Y. W.; Yoon, K. D.; Ryu, M. Y.; Yang, M. H.; Lee, J. H.; Kim, J. W. Kor. J. Pharmacogn. 2008, 39, 357-364.
  17. Wu, T. S.; Kuoh, C. S.; Furukawa, H. Chem. Pharm. Bull. 1983, 31, 895-900. https://doi.org/10.1248/cpb.31.895
  18. Abreu, V. G. C.; Silva, M. C.; Magalhaes, R. M.; Pilo-Veloso, D.; Xavier, I. F. S.; Oliveira, P. M.; Alcantra, A. F. C. Acta Amazonica 2010, 40, 711-718. https://doi.org/10.1590/S0044-59672010000400011
  19. Lee, K. H.; Soine, T. O. J. Pharm. Sci. 1969, 58, 675-681. https://doi.org/10.1002/jps.2600580605
  20. Frank, K.; Porzel, A.; Masaoud, M.; Adam, G.; Schmidt, J. Phytochemistry 2001, 56, 611-621. https://doi.org/10.1016/S0031-9422(00)00419-2
  21. Fujioka, T.; Furumi, K.; Fujii, H.; Okabe, H.; Mihashi, K.; Nakano, Y.; Matsunaga, H.; Katano, M.; Mori. M. Chem. Pharm. Bull. 1999, 47, 96-100. https://doi.org/10.1248/cpb.47.96
  22. An, R. B.; Park, B. Y.; Kim, J. H.; Kwon, O. K.; Lee, J. K.; Min, B. S.; Ahn, K. S.; Oh, S. R.; Lee, H. K. Nat. Prod. Sci. 2005, 11, 79-84.
  23. Park, H. Y.; Kwon, S. B.; Heo, N. K.; Chun, W.; Kim, M. J.; Kwon, Y. J. Korean Soc. Appl. Biol. Chem. 2011, 54, 194-199.
  24. Skalicak-Wo niak, K.; Mroczek, T.; Garrard, I.; G owniak, K. J. Sep. Sci. 2012, 35, 790-797. https://doi.org/10.1002/jssc.201100815
  25. Wang, L.; Yu, M. M.; Chi, Y. Q.; Ouyang, W. B.; Zang, Z.; Zhao, Y. Zhongguo Zhong Yao Za Zhi, 2014, 39, 3969-3973.
  26. Kong, L. Y.; Yao, N. H. Chin. Chem. Lett. 2000, 11, 315-318.
  27. Lee, H. K.; Oh, S. R.; Kwon, O. K.; Ahn, K. S.; Lee, J.; Kim, J. C.; Min, B. S.; Joung, H. Phytother. Res. 2007, 21, 406-409. https://doi.org/10.1002/ptr.2082
  28. Steck, W.; Mazurek, M. Lloydia 1972, 35, 418-439.
  29. Cairns, N.; Harwood, L. M.; Astles, D. P. Tetrahedron 1992, 36, 7581-7590.
  30. Dominguez, X. A.; Cano, G.; Luna, I.; Dieck, A. Phytochemistry, 1977, 16, 1096. https://doi.org/10.1016/S0031-9422(00)86749-7
  31. Ritchie, E.; Taylor, W. C.; Young, L. M. Aust. J. Chem. 1968, 21, 1381-1382. https://doi.org/10.1071/CH9681381
  32. Lahey, F. N.; Wluka, D. J. Aust. J. Chem. 1955, 8, 125-128.
  33. Kim, D. K; Lim, J. P.; Yang, J. H.; Eom, D. O.; Eun, J. S.; Leem, K. H. Arch. Pharm. Res. 2002, 25, 856-859. https://doi.org/10.1007/BF02977004
  34. Lee, J. H.; Lee, K. T.; Yang, J. H.; Baek, N. I.; Kim. D. K. Arch. Pharm. Res. 2004, 27, 53-56. https://doi.org/10.1007/BF02980046
  35. Kang, S. Y.; Lee, K. Y.; Sung, S. H.; Park, M. J.; Kim, Y. C. J. Nat. Prod. 2001, 64, 683-685. https://doi.org/10.1021/np000441w

피인용 문헌

  1. Chemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials of Artemisia copa Phil. (Asteraceae) vol.11, pp.None, 2020, https://doi.org/10.3389/fphar.2020.594174
  2. Identifying the compounds that can distinguish between Saposhnikovia root and its substitute, Peucedanum ledebourielloides root, using LC-HR/MS metabolomics vol.74, pp.3, 2017, https://doi.org/10.1007/s11418-020-01409-6
  3. 강활(Ostericum koreanum) 줄기의 성분 vol.51, pp.3, 2017, https://doi.org/10.22889/kjp.2020.51.3.158