Korean Journal of Psychosomatic Medicine (정신신체의학)

Korean Psychosomatic Society (한국정신신체의학회)
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Gender Difference in Associations between Serum Cholesterol Levels and Depression Symptoms in Healthy General Population

건강한 성인에서 성별에 따른 혈중 콜레스테롤 농도와 우울증상의 연관성 : 후향적 의무기록 조사

  • Lee, So Hee (Seoul National University Hospital, Healthcare System Gangnam Center) ;
  • Park, Mina (Seoul National University Hospital, Healthcare System Gangnam Center) ;
  • Yoon, Dae Hyun (Seoul National University Hospital, Healthcare System Gangnam Center) ;
  • Lee, Young (Seoul National University Hospital, Healthcare Research Institute, Healthcare System Gangnam Center) ;
  • Kim, Sun Shin (Seoul National University Hospital, Healthcare System Gangnam Center)
  • 이소희 (서울대학교병원 헬스케어시스템 강남센터) ;
  • 박미나 (서울대학교병원 헬스케어시스템 강남센터) ;
  • 윤대현 (서울대학교병원 헬스케어시스템 강남센터) ;
  • 이영 (서울대학교병원 강남센터 헬스케어 연구소) ;
  • 김선신 (서울대학교병원 헬스케어시스템 강남센터)
  • Received : 2016.12.02
  • Accepted : 2017.03.07
  • Published : 2017.06.30
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Abstract

Objectives : The purpose of this study was to determine the association between serum lipid profiles and depression according to gender difference. Methods : This retrospective cohort study included 27,452 subjects(15044 men and 12408 women) who underwent health examination. The duration was from January 2013 to December 2013. We estimate the correlation between serum lipid profile and Beck Depression Inventory(BDI) scores. We compare the effect size using beta coefficient. Results : In men, serum Triglyceride level was correlated positively with BDI scores(r=0.020, p<0.01). Serum LDL-C and HDL-C were negatively correlated with BDI scores(r=-0.015, p<0.01 ; r=-0.016, p<0.05). In women, Triglyceride level was also correlated positively with BDI scores(r=0.020, p<0.01), Serum HDL-C were negatively correlated with BDI scores(r=-0.019, p<0.01). There was no statistical significance between Serum LDL-C and Beck Depression Inventory(BDI) score. Conclusions : Both men and women had more depressive symptoms when they had low serum HDL-C level or high serum Triglyceride level. The depression symptoms were more severe when serum LDL-C level was low only in men.

연구목적 본 연구는 우울 증상과 혈중 콜레스테롤 농도의 연관성이 성별에 따라 차이가 있는지 살펴보고자 하였다. 방법 건강검진을 받은 일반인 중 27,452명(남자 15,044명, 여성 12,408명)을 대상으로 후향적 의무기록 조사를 통하여 이루어졌다. 대상자들의 벡우울척도(Beck Depression Inventory, BDI)점수를 구하고 총콜레스테롤(Total cholesterol, TC), 중성지방(Triglyceride, TG)), 고밀도 지단백 콜레스테롤(High density lipoprotein cholesterol, HDL-C), 저밀도 지단백 콜레스테롤(Low density lipoprotein cholesterol, LDL-C)을 분석하였다. 결과 남성은 총콜레스테롤(TC)과 벡우울척도(BDI) 점수 사이에는 통계적으로 유의한 상관성을 보이지 않았다. 중성지방(TG)은 벡우울척도(BDI) 점수와 양의 상관성을 보였으며(r=0.020, p<0.01), 고밀도 지단백 콜레스테롤(HDL-C)와 저밀도 지단백 콜레스테롤(LDL-C)은 벡우울척도(BDI) 점수와 음의 상관성을 보였다(r=-0.016, p<0.01 ; r=-0.015, p<0.05) 여성의 경우도 총콜레스테롤(TC)과 벡우울척도(BDI) 점수 사이에는 통계적으로 유의한 상관성이 없었으며 중성지방(TG)은 벡우울척도(BDI)점수와 양의 상관성을 보였고(r=0.020, p<0.01) 고밀도 지단백 콜레스테롤(HDL-C)과는 음의 상관성을 보였다(r=-0.019, p<0.01). 남성과 달리 저밀도 지단백 콜레스테롤(LDL-C)은 통계적으로 유의한 상관성을 보이지 않았다. 결론 남녀 모두 중성지방(TG)이 높을수록, 고밀도 지단백 콜레스테롤(HDL-C)이 낮을수록 우울 증상의 정도가 심한 것으로 나타났으며, 남성에서만 저밀도 지단백 콜레스테롤(LDL-C)이 낮을수록 우울 증상이 심한 것으로 나타났다.

Keywords

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