Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of KV Pharmacopuncture on MIA-induced Osteoarthritis Rat

KV 약침이 MIA로 관절염을 유도한 랫드에 미치는 효과

  • Park, Byung Jun (Young jin Korea Medical Clinic) ;
  • Choi, Hak Joo (Traditional and Biomedical Research Center (TBRC), Daejeon University) ;
  • Sim, Boo Yong (Traditional and Biomedical Research Center (TBRC), Daejeon University) ;
  • Yun, Mi Young (Department of Beuty Science, Kwangju Women's University) ;
  • Yoo, Ji Hyun (Department of Herbal Pharmaceutical Science, Joongbu University) ;
  • Kim, Dong Hee (Department of Pathology, College of Korean Medicine, Daejeon University)
  • 박병준 (영진한의원) ;
  • 최학주 (대전대학교 난치성 면역질환의 동서생명의학연구 지역혁신센터) ;
  • 심부용 (대전대학교 난치성 면역질환의 동서생명의학연구 지역혁신센터) ;
  • 윤미영 (광주여자대학교 미용과학과) ;
  • 유지현 (중부대학교 한방제약과학과) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Received : 2016.11.11
  • Accepted : 2016.01.07
  • Published : 2017.02.25
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study is to investigate anti-arthritis activity using a KV pharmacopuncture. KV pharmacopuncture was inserted at BL40 for 4 weeks to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 60 mg/ml. MMP-9, CTX II, LTB4, calcitonin and glycosaminoglycan level in serum were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Also, The histopathological change of knee was observed by H&E and safranin-O staining. Production of MMP-9, CTX II and LTB4 level in serum was decreased, respectively, in comparison with control. The other way, production of calcitonin and glycosaminoglycan level in serum was increased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the KV group showed a increase in the cartilage volume and proteoglycan. These results may be used a remedy for new korea medicine to ease the symptoms mentioned above.

Keywords

References

  1. Korean Statistical Information Service. Inforation: Population census. [cited 2017 Jan 28]. Available from: http://kosis.kr/statisticsList/statisticsList_01List.jsp?vwcd =MT_ZTITLE&parentId=D#SubCont.
  2. Korean College of Rheumatology. KCR textbook of rheumatology. Seoul: Koonja; 2014.
  3. The Society of Korean Medicine Rehabilitation. Oriental rehabilitation medicine. 2nd ed. Seoul: Koonja; 2005.
  4. Couture RR, Cuello AC. Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat. The Journal of physiology. 1984 Jan 1;346(1):273-85. https://doi.org/10.1113/jphysiol.1984.sp015021
  5. Park S, Kim YS, Lee D, Kwon Y, Park J, Lee SY, et al. Efficacy and safety of HT008 and glucosamine sulfate in the treatment of knee osteoarthritis: a randomized double-blind trial. The Korea Journal of Herbology. 2014;29(4):45-52. https://doi.org/10.6116/KJH.2014.29.4.45
  6. Lee YE, Lee YK, Kim JS, Lee HJ. Effects of Clematidis Radix Pharmacopuncture on MIA induced Osteoarthritis Rat. The Acupuncture. 2016 Jun 20;33(2):35-49. https://doi.org/10.13045/acupunct.2016015
  7. Korean Acupuncture & Moxibustion Society. The Acupuncutre and Moxibustion Medicine. Seoul: Jibmoondang; 2012.
  8. An HJ, Lee CK, Park JH, Kim KH, Lee WR, Park IY, et al. Effects of bee venom on papain-induced osteoarthritis in an animal model. Korean Journal of Pharmacognosy. 2012;43(2):167-72.
  9. Kim HS, Seo IB, Park SK, Kim JS, Seo JC, Choi SM, et al. Effects of Aconitum pseudo-laeve on Nitric Oxide Synthase in the Periaqueductal Gray of Collagenase-induced Rat Osteoarthritis Model. Korean Journal of Acupuncture. 2006;23(1):87-94.
  10. National College of Oriental Medicine co-edited a book. Herbal medicine. Seoul: Youngrimsa; 2004.
  11. Korean Pharmacology Textbook Compilation Committee. Pharmacology. Seoul: Sinilsangsa; 1992.
  12. Lee BK, Lee YC, Lee JC. Inhibitory Effect of a Decoction of Eucommiae ulmides OLIVER and Dipsacus asperoides CY Cheng et TM Ai on Collagen II-induced Arthritis Mice. The Korea Journal of Herbology. 2010;25(1):55-63.
  13. Yoon CH. Current clinical practice: osteoarthritis update. The Korean journal of medicine. 2012;82(2):170-4. https://doi.org/10.3904/kjm.2012.82.2.170
  14. Kim W, Choi J. Effects of bee venom and Cervi cornu parvum pharmacoacupuncture in monosodium iodoacetate (MIA)-induced osteoarthritis rat. The Korean Academy of Oriental Rehabilitation Medicine. 2010;20(1):61-77.
  15. Peters-Golden M, Henderson Jr WR. Leukotrienes. New England Journal of Medicine. 2007 Nov 1;357(18):1841-54. https://doi.org/10.1056/NEJMra071371
  16. Reijman M, Hazes JM, Bierma‐Zeinstra SM, Koes BW, Christgau S, Christiansen C, et al. A new marker for osteoarthritis: cross‐sectional and longitudinal approach. Arthritis & Rheumatism. 2004 Aug 1;50(8):2471-8. https://doi.org/10.1002/art.20332
  17. Stashak TS. Adams' lameness in horses. Verlag M. & H. Schaper; 2008.

Cited by

  1. MIA로 퇴행성관절염을 유도한 랫드에 방사선 형질전환 차조기가 증상 예방 및 완화에 미치는 효과 vol.37, pp.4, 2020, https://doi.org/10.12925/jkocs.2020.37.4.830
  2. 방사선 육종 차조기와 백출 복합물이 조골세포와 파골세포의 활성에 미치는 영향 vol.38, pp.1, 2021, https://doi.org/10.12925/jkocs.2021.38.1.168