Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

  • Received : 2016.10.25
  • Accepted : 2017.01.03
  • Published : 2017.05.01
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Abstract

Objective: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine. Methods: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected. Results: Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups. Conclusion: In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

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References

  1. Kabploy K, Bunyapraphatsara N, Morales NP, Paraksa N. Effect of antibiotic growth promoters on anti-oxidative and anti-inflammatory activities in broiler chickens. Thai J Vet Med 2016;46:89-95.
  2. Khan SH, Iqbal J. Recent advances in the role of organic acids in poultry nutrition. J Appl Anim Res 2016;44:359-69. https://doi.org/10.1080/09712119.2015.1079527
  3. Moquet PCA, Onrust L, Van Immerseel F, et al. Importance of release location on the mode of action of butyrate derivatives in the avian gastrointestinal tract. World's Poult Sci J 2016;72:61-80. https://doi.org/10.1017/S004393391500269X
  4. Van Immerseel F, Fievez V, Buck JD, et al. Microencapsulated shortchain fatty acids in feed modify colonization and invasion early after infection with Salmonella Enteritidis in young chickens. Poult Sci 2004;83:69-74. https://doi.org/10.1093/ps/83.1.69
  5. Qaisrani SN, van Krimpen MM, Kwakkel RP, Verstegen MWA, Hendriks WH. Diet structure, butyric acid, and fermentable carbohydrates influence growth performance, gut morphology, and cecal fermentation characteristics in broilers. Poult Sci 2015;94:2152-64. https://doi.org/10.3382/ps/pev003
  6. Chamba F, Puyalto M, Ortiz A, et al. Effect of partially protected sodium butyrate on performance, digestive organs, intestinal villi and E. coli development in broilers chickens. Int J Poult Sci 2014;13:390-6. https://doi.org/10.3923/ijps.2014.390.396
  7. Fang CL, Sun H, Wu J, Niu H, Feng J. Effects of sodium butyrate on growth performance, haematological and immunological characteristics of weanling piglets. J Anim Physiol Anim Nutr 2014;98:680-5. https://doi.org/10.1111/jpn.12122
  8. Sunkara LT, Achanta M, Schreiber NB, et al. Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression. PLoS one 2011;6:e27225. https://doi.org/10.1371/journal.pone.0027225
  9. Ahsan U, Cengiz O, Raza I, et al. Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity. World's Poult Sci J 2016;265-75.
  10. Hassan HMA, Mohamed MA, Youssef AW, Hassan ER. Effect of using organic acids to substitute antibiotic growth promoters on performance and intestinal microflora of broilers. Asian-Australas J Anim Sci 2010;23:1348-53. https://doi.org/10.5713/ajas.2010.10085
  11. Abdelqader A, Al-Fataftah A. Effect of dietary butyric acid on performance, intestinal morphology, microflora composition and intestinal recovery of heat-stressed broilers. Livest Sci 2016;183:78-83. https://doi.org/10.1016/j.livsci.2015.11.026
  12. Kiczorowska B, Al-Yasiry ARM, Samolinska W, Marek A, Pyzik E. The effect of dietary supplementation of the broiler chicken diet with Boswellia serrata resin on growth performance, digestibility, and gastrointestinal characteristics, morphology, and microbiota. Livest Sci 2016;191:117-24. https://doi.org/10.1016/j.livsci.2016.07.019
  13. Corrier DE. Comparison of phytohemagglutinin-induced cutaneous hypersensitivity reactions in the interdigital skin of broiler and layer chicks. Avian Dis 1990;34:369-73. https://doi.org/10.2307/1591421
  14. King DJ. A comparison of the onset of protection induced by Newcastle disease virus strain B1 and a fowl poxvirus recombinant Newcastle disease vaccine to a viscerotropic velogenic Newcastle disease virus challenge. Avian Dis 1999;43:745-55. https://doi.org/10.2307/1592743
  15. Madej JP, Stefaniak T, Bednarczyk M. Effect of in ovo-delivered prebiotics and synbiotics on lymphoid-organs' morphology in chickens. Poult Sci 2015;94:1209-19. https://doi.org/10.3382/ps/pev076
  16. Anwar S. Effect of dietary supplementation of Catharanthus roseus on gross and micro-structures of selected internal organs of broilers [M.Phil thesis]. Lahore, Pakistan: University of Veterinary and Animal Sciences; 2013.
  17. Sikandar A, Cheema AH, Younus M, et al. Histopathological and serological studies on paratuberculosis in cattle and buffaloes. Pak Vet J 2012;32:547-51.
  18. Bancroft JD, Gamble M, Bancroft OD. Theory and practice of histological techniques. 6th ed. New York, NY: Elsevier Health Sciences;2008.
  19. Ashraf S, Zaneb H, Yousaf MS, et al. Effect of dietary supplementation of prebiotics and probiotics on intestinal microarchitecture in broilers reared under cyclic heat stress. J Anim Physiol Anim Nutr (Berl) 2013;1(Suppl):68-73.
  20. Rieger J, Janczyk P, Hunigen H, Neumann K, Plendl J. Intraepithelial lymphocyte numbers and histomorphological parameters in the porcine gut after Enterococcus faecium NCIMB 10415 feeding in a Salmonella Typhimurium challenge. Vet Immunol Immunopathol 2015;164:40-50. https://doi.org/10.1016/j.vetimm.2014.12.013
  21. Dehghani-Tafti N, Jahanian R. Effect of supplemental organic acids on performance, carcass characteristics, and serum biochemical metabolites in broilers fed diets containing different crude protein levels. Anim Feed Sci Technol 2016;211:109-16. https://doi.org/10.1016/j.anifeedsci.2015.09.019
  22. Zhang WH, Jiang Y, Zhu QF, et al. Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens. Br Poult Sci 2011;52:292-301. https://doi.org/10.1080/00071668.2011.578121
  23. Schrank CS, Cook ME, Hansen WR. Immune response of Mallard Ducks treated with immunosuppressive agents: antibody response to erythrocytes and in vivo response to phytohemagglutinin-P. J Wildlife Dis 1990;26:307-15. https://doi.org/10.7589/0090-3558-26.3.307
  24. Geng T, Guan X, Smith EJ. Screening for genes involved in antibody response to sheep red blood cells in the chicken, Gallus gallus. Poult Sci 2015;94:2099-107. https://doi.org/10.3382/ps/pev224
  25. El-Abasy M, Motobu M, Sameshima T, et al. Adjuvant effects of sugar cane extracts (SCE) in chickens. J Vet Med Sci 2003;65:117-9. https://doi.org/10.1292/jvms.65.117
  26. Park J, Kim M, Kang SG, et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 2015;8:80-93. https://doi.org/10.1038/mi.2014.44
  27. Zhou ZY, Packialakshmi B, Makkar SK, Dridi S, Rath NC. Effect of butyrate on immune response of a chicken macrophage cell line. Vet Immunol Immunopathol 2014;162:24-32. https://doi.org/10.1016/j.vetimm.2014.09.002
  28. Eshak MG, Elmenawey MA, Atta A, et al. The efficacy of Na-butyrate encapsulated in palm fat on performance of broilers infected with necrotic enteritis with gene expression analysis. Vet World 2016;9:450-7. https://doi.org/10.14202/vetworld.2016.450-457
  29. Chang PV, Hao L, Offermanns S, Medzhitov R. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci 2014;111:2247-52. https://doi.org/10.1073/pnas.1322269111
  30. Majidi-Mosleh A, Sadeghi AA, Mousavi SN, Chamani M, Zarei A. Influence of in ovo inoculation of probiotic strains on the jejunal goblet cell counts and morphometry in peri- and post-hatching chicks. Kafkas Univ Vet Fak Derg 2017;23:169-72.

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