생약학회지 (Korean Journal of Pharmacognosy)

  • 제48권1호
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  • Pages.82-87
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  • 2017
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

고려인삼의 부위별 Malonyl Ginsenoside 함량 비교 분석

Comparison of Malonyl Ginsenoside Contents in Parts of Korean Ginseng

  • 박영식 ((재)금산국제인삼약초연구소) ;
  • 오명환 ((재)금산국제인삼약초연구소) ;
  • 이환 ((재)금산국제인삼약초연구소) ;
  • 정종태 ((재)금산국제인삼약초연구소) ;
  • 조윤호 ((재)금산국제인삼약초연구소) ;
  • 표미경 ((재)금산국제인삼약초연구소)
  • Park, Young Sik (International Ginseng & Herb Research Institute) ;
  • Oh, Myeong Hwan (International Ginseng & Herb Research Institute) ;
  • Lee, Hwan (International Ginseng & Herb Research Institute) ;
  • Jung, Jong Tae (International Ginseng & Herb Research Institute) ;
  • Jo, Yun Ho (International Ginseng & Herb Research Institute) ;
  • Pyo, Mi Kyung (International Ginseng & Herb Research Institute)
  • 투고 : 2016.12.30
  • 심사 : 2017.03.03
  • 발행 : 2017.03.31
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초록

Malonyl ginsenoside content of the Panax ginseng C.A. Meyer is known to account for 35% to 60% of total ginsenosides content. However, its distribution by ginseng part has not been studied. In this study, four kinds of malonyl ginsenosides were compared in Korean white ginseng part using the purified malonyl ginsenoside standards in our laboratory. White ginseng was prepared by the freeze drying ($-70^{\circ}C$, 48 h) or air drying ($50^{\circ}C$, 48 h) methods form 4-year-old ginseng. Malonyl ginsenoside content of main, lateral, and fine root, and of the main root without skin and its skin was compared. Malonyl ginsenosides (m-Rb1, m-Rb2, m-Rc and m-Rd) content (58%, 19.17 mg/g) in total ginsenosides of air dried white ginseng was decreased about 4% compared to its content of freeze dried white ginseng (62%, 20.40 mg/g). Malonyl ginsenoside content was the highest in fine root, compared to the main or lateral root. Malonyl ginsenosides content in skin of main root was 20.08 mg/g, while its content of the main root without skin was 2.58 mg/g. These results are expected to help establishment of quality specification and processing process in Korean white ginseng.

키워드

참고문헌

  1. Park, J. D., Wee, J. J., Kim, Y. S., Kim, S. K. and Park, K. H. (1996) A comparative biological study of the rhizome and main root from red and white ginsengs. Korean J. Ginseng Sci. 20: 256-261.
  2. Im, K., Kim, J. and Min, H. (2016) Ginseng, the natural effectual antiviral: Protective effects of Korean red ginseng against viral infection. J. Ginseng Res. 40: 309-314. https://doi.org/10.1016/j.jgr.2015.09.002
  3. Lee, N., Lee, S. H., Yoo, H. R. and Yoo, H. S. (2016) Antifatigue effects of enzyme-modified ginseng extract: a randomized, double-blind, placebo-controlled trial. J. Altern. Complement Med. 22: 859-864. https://doi.org/10.1089/acm.2016.0057
  4. Yuan, H. D., Kim, J. T., Kim, S. H. and Chung, S. H. (2012) Ginseng and diabetes: the evidences from in vitro, animal and human studies. J. Ginseng Res. 36: 27-39. https://doi.org/10.5142/jgr.2012.36.1.27
  5. Hong, M., Lee, Y. H., Kim, S., Suk, K. T., Bang, C. S., Yoon, J. H., Baik, G. H., Kim, D. J. and Kim, M. J. (2016) Antiinflammatory and antifatigue effect of korean red ginseng in patients with nonalcoholic fatty liver disease. J. Ginseng Res. 40: 203-210. https://doi.org/10.1016/j.jgr.2015.07.006
  6. Lee, H. Y., Park, K. H., Park, Y. M., Moon, D. I., Oh, H. G., Kwon, D. Y., Yang, H. J., Kim, O., Kim, D. W., Yoo, J. H., Hong, S. C., Lee, K. H., Seol, S. Y., Park, Y. S., Park, J. D. and Pyo, M. K. (2014) Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice. Lab. Anim. Res. 30: 151-160. https://doi.org/10.5625/lar.2014.30.4.151
  7. Lee, Y. and Oh, S. (2015) Administration of red ginseng ameliorates memory decline in aged mice. J. Ginseng Res. 39: 250-256. https://doi.org/10.1016/j.jgr.2015.01.003
  8. Yun, T. K., Lee, Y. S., Lee, Y. H. and Yun, H. Y. (2001) Cancer chemopreventive compounds of red ginseng produced from Panax ginseng C.A. Meyer. J. Ginseng Res. 25: 107-111.
  9. Lee, S. E., Lee, S. U., Bang, J. K., Yu, Y. J. and Seong, R. S. (2004) Antioxidant activities of leaf, stem and root of Panax ginseng C.A. Meyer. Korean J. Med. Corp. Sci. 21: 184-190.
  10. Liu, Z., Li, Y., Li, X., Ruan, C. C., Wang, L. J. and Sun, G. Z. (2012) The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng C.A. Meyer. J. Pharm. Biomed. Anal. 64-65: 56-63. https://doi.org/10.1016/j.jpba.2012.02.005
  11. Li, X., Kang, S. J., Han, J. S., Kim, J. S. and Choi, J. E. (2009) Effects of root diameter within different root parts on ginsenoside composition of Yunpoong cultivar in Panax ginseng C. A. Meyer. Korean J. Med. Corp. Sci. 17: 452-457.
  12. Liu, Z., Li, W., Li, X., Zhang, M., Chen, L., Zheng, Y. N., Sun, G. Z. and Ruan, C. C. (2013) Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats in duced by high-fat diet and streptozotocin. J. Ethnopharmacol. 145: 233-240. https://doi.org/10.1016/j.jep.2012.10.058
  13. Du, X. W., Wills, R. B. H. and Stuart, D. L. (2004) Changes in neutral and malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction. Food Chemistry. 86: 155-159. https://doi.org/10.1016/j.foodchem.2003.11.003
  14. Lee, K. H., Lee, D. Y., Lee, S. E., Nam, K. Y., Hwang, G. B., Kim, H. D., Lee, J. W., Choi, J. H., Ahn, Y. S., Kim, S. Y. and Kim, G. S. (2016) Evaluation on extraction conditions and hplc analysis method for ginsenosides in Panax ginseng. Korean J. Med. Corp. Sci. 24: 47-54. https://doi.org/10.7783/KJMCS.2016.24.1.47
  15. Jang, J. G., Lee, K. S., Kwon, D. W. and Oh, H. K. (1987) Chemical compositions of Korean ginseng with special reference to the part of ginseng plant. Korean J. Ginseng Sci. 11: 84-89.
  16. Kitagawa, I., Taniyama, T., Yoshikawa, M., Ikenishi, Y. and Nakagawa, Y. (1989) Chemical studies on crude drug processing. VI. Chemical structures of malonyl-ginsenosides Rb1, Rb2, Rc, and Rd Isolated from the Root of Pnax ginseng C.A. Meyer. Chem. Pharm. Bull. 37: 2961-2970. https://doi.org/10.1248/cpb.37.2961
  17. Ahn, I. O., Lee, S. S.,, Lee, J. H., Lee, M. J. and Jo, B. G. (2008) Comparison of ginsenoside contents and pattern similarity between root parts of new cultivars in Panax ginseng C.A. Meyer. J. Ginseng Res. 32: 15-18. https://doi.org/10.5142/JGR.2008.32.1.015
  18. Choi, J. E., Nam, K. Y., Li, X., Kim, B. Y., Cho, H. S. and Hwang, K. B. (2010) Changes of chemical compositions and ginsenoside contents of different root parts of ginsengs with processing method. Korean J. Medicinal Crop. Sci. 18: 118-125.
  19. Han, J. S., Tak, H. S., Lee, G. S., Kim, J. S. and Choi, J. E. (2013) Comparison of ginsenoside content according to age and diameter in Panax ginseng C. A. Meyer cultivated by direct seeding. Korean J. Medicinal Crop. Sci. 21: 184-190. https://doi.org/10.7783/KJMCS.2013.21.3.184
  20. Oh, M. H., Park, Y. S., Lee, H., Kim, N. Y., Jang, Y. B., Park, J. H., Kwak, J. Y., Park, Y. S., Park, J. D. and Pyo M. K. (2016) Comparison of physicochemical properties and malonyl ginsenoside contents between white and red ginseng. Kor. J. Pharmacogn. 47: 84-91.
  21. Han, J. S., Tak, H. S., Lee, G. S., Kim, J. S., Woo, R. J. and Choi, J. E. (2013) Comparison of ginsenoside content and ratio of root tissue according to root age and diameter in Panax ginseng C. A. Meyer. Korean J. Medicinal Crop. Sci. 21: 342-347. https://doi.org/10.7783/KJMCS.2013.21.5.342