Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

  • Kim, Hyun Pyo (College of Pharmacy, Kangwon National University) ;
  • Lim, Hyun (College of Pharmacy, Kangwon National University) ;
  • Kwon, Yong Soo (College of Pharmacy, Kangwon National University)
  • Received : 2016.08.18
  • Accepted : 2016.10.04
  • Published : 2017.03.01
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Abstract

Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription $factor-{\kappa}B$ activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.

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References

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